A5055967107- Genetic and phenotypic traits in livestock
- Cancer-related molecular mechanisms research
- Effects of Environmental Stressors on Livestock
- Meat and Animal Product Quality
- Genetic Mapping and Diversity in Plants and Animals
- Circular RNAs in diseases
- Livestock Farming and Management
- Genetic diversity and population structure
- Adipose Tissue and Metabolism
- Genomic variations and chromosomal abnormalities
- Animal Nutrition and Physiology
- Heat shock proteins research
- Essential Oils and Antimicrobial Activity
- Genomics and Chromatin Dynamics
- melanin and skin pigmentation
- RNA modifications and cancer
- Chromosomal and Genetic Variations
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Ruminant Nutrition and Digestive Physiology
- Environmental and Agricultural Sciences
- Plant biochemistry and biosynthesis
- Peroxisome Proliferator-Activated Receptors
- RNA Research and Splicing
- Animal Genetics and Reproduction
Academe of Grassland And Animal Science
2014-2025
Northwest A&F University
2020
National Institute for Biotechnology and Genetic Engineering
2020
Pakistan Institute of Engineering and Applied Sciences
2020
National Beef Cattle Industrial Technology System
2010
Yunnan Agricultural University
2004
Indicine cattle, also referred to as zebu (Bos taurus indicus), play a central role in pastoral communities across wide range of agro-ecosystems, from extremely hot semiarid regions humid tropical regions. However, their adaptive genetic changes following dispersal into East Asia the Indian subcontinent have remained poorly documented. Here, we characterize global diversity using high-quality whole-genome sequencing data 354 indicine cattle 57 breeds/populations, including major...
Myogenesis is controlled by a well-established transcriptional hierarchy that coordinates the activities of set muscle genes. Recently, roles in myogenesis have been described for non-coding RNAs, including role circular RNA (circRNA) to regulate gene expression. However, functions circRNA and underlying mechanism which circRNAs affect remain poorly understood. In this study, we analyzed high-throughput sequencing results bovine skeletal samples constructed circRNA-miRNA-mRNA network...
There is growing evidence that non-coding RNAs are emerging as critical regulators of skeletal muscle development. In order to reveal their functional roles and regulatory mechanisms, we constructed a lncRNA-miRNA-mRNA network according the ceRNA (competitive endogenous RNA) theory, using our high-throughput sequencing data. Subsequently, analysis, GO (Gene Ontology) KEGG (Kyoto Encyclopedia Genes Genomes) pathway analysis were performed for annotation exploration lncRNA ceRNAs. The results...
Yunnan Province, located in Southwestern China, the intricate geography, variable climate, and abundant vegetation of region have collectively contributed to shaping distinctive germplasm characteristics observed indigenous cattle through prolonged domestication. The different breeds exhibit distinct advantageous traits, which are an important source genetic variation because they might carry alleles that enable them adapt local environment tough feeding conditions. However, a comprehensive...
Complete mitochondrial DNA D-loop sequences of 1105 individuals were used to assess the diversity maternal lineages cattle populations in China. In total, 250 taurine and 88 zebu haplotypes identified. Five main haplogroups-T1a, T2, T3, T4 T5-were identified Bos taurus, whereas indicus harbored two haplogroups-I1 I2. Our results suggest that distribution T1a Asia was concentrated mainly northeast region (northeast China, Korea Japan); haplogroups T3 predominant Chinese cattle; T5...
Intramuscular fat (IMF) content and fatty acid (FA) composition vary significantly across beef cattle breeds, which play an important role in taste nutritional value. However, the molecular mechanisms underlying these phenotypic differences remain unknown. The present study compared meat quality traits between Yunling Chinese Simmental cattle. showed a lower IMF proportion of monounsaturated acids (MUFA), as well higher proportions saturated (SFA), polyunsaturated (PUFA), short-chain (sc-FA)...
Abstract Body size plays a key role in production, health, selection, and environmental adaptation of animals, but the genetic basis body variation is not clearly understood. Here, we conducted genome-wide association studies (GWAS) 15 traits using autosomal single nucleotide polymorphisms (SNPs) derived from whole-genome sequences 31 Brahman cattle 131 Yunling identified 20 significant loci, which implicated 18 candidate genes. For ischium width, most SNP was assigned to LCORL, famous gene...
Objective Mulberry (Morus alba L.) is a cultivated shrub grown widely in the sub-tropical and tropical areas. It has been shown that mulberry leaf contains high levels of protein while having polyphenols as phytonutrients. Therefore, it important to conduct an experiment assess potential toxic level from on behavior, blood hematological coagulation parameter using Sprague-Dawley (SD) rats. Methods Both male female SD rats were given intragastric administration respective treatments intakes...
With its vast territory and complex natural environment, China boasts rich cattle genetic resources. To gain the further insight into diversity paternal origins of Chinese cattle, we analyzed polymorphism Y-SNPs (UTY19 ZFY10) Y-STRs (INRA189 BM861) in 34 breeds/populations, including 606 males representative 24 breeds/populations collected this study as well previously published data for 302 bulls. Combined genotypic identified 14 Y-chromosome haplotypes that represented three haplogroups....
Yunling cattle are a composite beef breed, combining Brahman (1/2), Murray Grey (1/4) and Local Yunnan (1/4), that was developed in Yunnan, China the 1980s. Understanding genetic information of is great significance to development reasonable breeding strategies for this breed. In present study, we assessed current status Province (China) by analyzing variability whole mitochondrial genome 129 individuals. Altogether, sequences displayed 47 different haplotypes. The haplotype diversity...
Abstract Yunling cattle, a three‐breed cross consisting of 1/2 Brahman 1/4 Murray Grey cattle and Yunnan Yellow has advantage rapid growth, good meat quality, enhanced tolerance towards hot humid climate, tick resistance crude feed forbearance. Here, we investigated the genetic diversity, global local ancestry proportions by sequencing genomes 131 Yungling 31 (for control). Furthermore, used 35 published breeds (including Angus [ancestry Grey], Wannan cattle: Wenshan Dianzhong], Dianzhong...
Based on the previous GWAS research related to bovine heat tolerance trait, this study aimed explore effect of myosin-1a (MYO1A) gene and find molecular markers Chinese cattle. In our study, four novel candidate SNPs highly conserved in B. indicus breeds but barely existed taurus were identified MYO1A according Bovine Genome Variation Database Selective Signatures (BGVD). PCR DNA sequencing used genotype 1072 individuals including 34 indigenous cattle as well Angus Indian zebu. Two...
Weining cattle is a Chinese indigenous breed influenced by complex breeding and geographical background. The multi-ethnic culture makes require more attention as livestock resources for its genetic diversity. Here, we used 10 (five newly sequenced five downloaded) downloaded another 48 genome data to understand the aspects of cattle: diversity, population structure, cold-adapted performance. In current study, high level diversity was found in cattle, comprised two potential ancestries, which...
Over the years, indigenous cattle have not only played an essential role in securing primary food sources but also been utilized for labor by humans, making them invaluable genetic resources. The Zhaotong cattle, a native Chinese breed from Yunnan province, possess excellent meat quality and resistance to heat humidity. Here we used whole genome sequencing data of 104 animals delve into population structure, genomic diversity potential positive selection signals cattle. findings this study...
The heat shock factor 1 (HSF1) gene is a regulator of the stress response, maximizing HSP protein expression survival. In this research, we explored frequency distribution missense mutation (NC_037341.1 g.616087A > G, rs135258919) in HSF1 Chinese cattle with amino acid substitution, valine to alanine. This could be related tolerance Bos indicus. A total 941 individuals representing 35 native breeds, combining pure taurine (Angus) and indicine cattle, were used determine genotypes through...
Stature is an important quantitative trait for cattle performance, which influences herd productivity. Previous studies have reported that SNP (AC_000171.1:g.25015640G>T, rs109815800) in Pleomorphic adenoma gene 1 (PLAG1) on chromosome 14 (CHR14) associated with bovine stature. To validate whether rs109815800 the body height of Chinese cattle, we carried out association analysis using 558 adult samples from seven populations. Then, 1038 38 breeds were used to show geographical distribution...
The location on the Yunnan border with Myanmar and its unique cultural landscape has shaped Lincang humped cattle over time. In current study, we investigated genetic characteristics of 22 using whole-genome resequencing data. We found that derived from both Indian indicine Chinese depicted higher levels genomic diversity. Based genome-wide scans, candidate regions were identified potentially involved in local thermal humid environmental adaptions, including genes associated body size...
Considerable evidence has demonstrated that the
We report genome characterization of three native Chinese cattle breeds discovering ~34.3 M SNPs and ~3.8 InDels using whole resequencing. On average, 10.4 were shared amongst the breeds, whereas, 3.0 M, 4.9 5.8 specific to LQ, WN WS respectively. Gene ontology (GO)analysis revealed four immune response-related GO terms over represented in all samples, while two signaling pathways significantly over-represented cattle. Altogether, we found related genes (PGLYRP2, ROMO1, FYB2, CD46, TSC1)...