A5044964653- Genetic and phenotypic traits in livestock
- Cancer-related molecular mechanisms research
- Genetic Mapping and Diversity in Plants and Animals
- Effects of Environmental Stressors on Livestock
- Meat and Animal Product Quality
- Genetic diversity and population structure
- Livestock Farming and Management
- Genomic variations and chromosomal abnormalities
- Heat shock proteins research
- Genomics and Chromatin Dynamics
- Chromosomal and Genetic Variations
- Genomics and Phylogenetic Studies
- melanin and skin pigmentation
- Circular RNAs in diseases
- Animal Genetics and Reproduction
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Identification and Quantification in Food
- Cancer-related gene regulation
- Neurological diseases and metabolism
- Adipose Tissue and Metabolism
- Biochemical Analysis and Sensing Techniques
- Animal Nutrition and Physiology
- Peroxisome Proliferator-Activated Receptors
- Sirtuins and Resveratrol in Medicine
Chuxiong Normal University
2021-2025
Academe of Grassland And Animal Science
2012-2022
Northwest A&F University
2012-2020
National Institute for Biotechnology and Genetic Engineering
2020
Pakistan Institute of Engineering and Applied Sciences
2020
Kunming Institute of Zoology
2007-2014
Chinese Academy of Sciences
2007-2014
National Beef Cattle Industrial Technology System
2006
Yunnan Agricultural University
2003
Abstract Background Previously reported evidence indicates that pigs were independently domesticated in multiple places throughout the world. However, a detailed picture of origin and dispersal domestic East Asia has not yet been reported. Results Population phylogenomic analysis was conducted wild boars by screening haplogroup-specific mutation motifs inferred from phylogenetic tree pig complete mitochondrial DNA (mtDNA) sequences. All are clustered into single clade D (which contains...
Indicine cattle, also referred to as zebu (Bos taurus indicus), play a central role in pastoral communities across wide range of agro-ecosystems, from extremely hot semiarid regions humid tropical regions. However, their adaptive genetic changes following dispersal into East Asia the Indian subcontinent have remained poorly documented. Here, we characterize global diversity using high-quality whole-genome sequencing data 354 indicine cattle 57 breeds/populations, including major...
Abstract The cross-species characterization of evolutionary changes in the functional genome can facilitate translation genetic findings across species and interpretation basis underlying complex phenotypes. Yet, this has not been fully explored between cattle, sheep, goats, other mammals. Here, we systematically characterized dynamics DNA methylation gene expression 3 somatic tissues (i.e. brain, liver, skeletal muscle) sperm 7 mammalian species, including ruminant livestock (cattle,...
Yunnan Province, located in Southwestern China, the intricate geography, variable climate, and abundant vegetation of region have collectively contributed to shaping distinctive germplasm characteristics observed indigenous cattle through prolonged domestication. The different breeds exhibit distinct advantageous traits, which are an important source genetic variation because they might carry alleles that enable them adapt local environment tough feeding conditions. However, a comprehensive...
Complete mitochondrial DNA D-loop sequences of 1105 individuals were used to assess the diversity maternal lineages cattle populations in China. In total, 250 taurine and 88 zebu haplotypes identified. Five main haplogroups-T1a, T2, T3, T4 T5-were identified Bos taurus, whereas indicus harbored two haplogroups-I1 I2. Our results suggest that distribution T1a Asia was concentrated mainly northeast region (northeast China, Korea Japan); haplogroups T3 predominant Chinese cattle; T5...
Intramuscular fat (IMF) content and fatty acid (FA) composition vary significantly across beef cattle breeds, which play an important role in taste nutritional value. However, the molecular mechanisms underlying these phenotypic differences remain unknown. The present study compared meat quality traits between Yunling Chinese Simmental cattle. showed a lower IMF proportion of monounsaturated acids (MUFA), as well higher proportions saturated (SFA), polyunsaturated (PUFA), short-chain (sc-FA)...
Abstract Body size plays a key role in production, health, selection, and environmental adaptation of animals, but the genetic basis body variation is not clearly understood. Here, we conducted genome-wide association studies (GWAS) 15 traits using autosomal single nucleotide polymorphisms (SNPs) derived from whole-genome sequences 31 Brahman cattle 131 Yunling identified 20 significant loci, which implicated 18 candidate genes. For ischium width, most SNP was assigned to LCORL, famous gene...
Gayal (Bos frontalis), also known as mithan or mithun, is a large endangered semi-domesticated bovine that has limited geographical distribution in the hill-forests of China, Northeast India, Bangladesh, Myanmar, and Bhutan. Many questions about gayal such its origin, population history, genetic basis local adaptation remain largely unresolved. De novo sequencing assembly whole genome provides an opportunity to address these issues. We report high-depth sequencing, de assembly, annotation...
Abstract Gayal ( Bos frontalis ) is a semi-wild and endangered bovine species that differs from domestic cattle taurus indicus its genetic background remains unclear. Here, we performed whole-genome sequencing of one for the first time, with Red Angus Japanese Black as controls. In total, 97.8 Gb reads were generated an average 11.78-fold depth >98.44% coverage reference sequence (UMD3.1). Numerous different variations identified, 62.24% total single nucleotide polymorphisms (SNPs)...
Longissimus dorsi muscle (LD) proteomics provides a novel opportunity to reveal the molecular mechanism behind intramuscular fat deposition. Unfortunately, vast amounts of lipids and nucleic acids in this tissue hampered LD analysis. Trichloroacetic acid (TCA)/acetone precipitation is widely used method remove contaminants from protein samples. However, high speed centrifugation employed produces hard precipitates, which restrict contaminant elimination re-dissolution. To address problem,...
With its vast territory and complex natural environment, China boasts rich cattle genetic resources. To gain the further insight into diversity paternal origins of Chinese cattle, we analyzed polymorphism Y-SNPs (UTY19 ZFY10) Y-STRs (INRA189 BM861) in 34 breeds/populations, including 606 males representative 24 breeds/populations collected this study as well previously published data for 302 bulls. Combined genotypic identified 14 Y-chromosome haplotypes that represented three haplogroups....
Yunling cattle are a composite beef breed, combining Brahman (1/2), Murray Grey (1/4) and Local Yunnan (1/4), that was developed in Yunnan, China the 1980s. Understanding genetic information of is great significance to development reasonable breeding strategies for this breed. In present study, we assessed current status Province (China) by analyzing variability whole mitochondrial genome 129 individuals. Altogether, sequences displayed 47 different haplotypes. The haplotype diversity...
Abstract Yunling cattle, a three‐breed cross consisting of 1/2 Brahman 1/4 Murray Grey cattle and Yunnan Yellow has advantage rapid growth, good meat quality, enhanced tolerance towards hot humid climate, tick resistance crude feed forbearance. Here, we investigated the genetic diversity, global local ancestry proportions by sequencing genomes 131 Yungling 31 (for control). Furthermore, used 35 published breeds (including Angus [ancestry Grey], Wannan cattle: Wenshan Dianzhong], Dianzhong...
Based on the previous GWAS research related to bovine heat tolerance trait, this study aimed explore effect of myosin-1a (MYO1A) gene and find molecular markers Chinese cattle. In our study, four novel candidate SNPs highly conserved in B. indicus breeds but barely existed taurus were identified MYO1A according Bovine Genome Variation Database Selective Signatures (BGVD). PCR DNA sequencing used genotype 1072 individuals including 34 indigenous cattle as well Angus Indian zebu. Two...
Weining cattle is a Chinese indigenous breed influenced by complex breeding and geographical background. The multi-ethnic culture makes require more attention as livestock resources for its genetic diversity. Here, we used 10 (five newly sequenced five downloaded) downloaded another 48 genome data to understand the aspects of cattle: diversity, population structure, cold-adapted performance. In current study, high level diversity was found in cattle, comprised two potential ancestries, which...
Porcine epidemic diarrhea virus (PEDV) is a member of the genus α-coronavirus and causes severe in piglets, leading to enormous economic losses pig industry. To understand variation PEDV strains Yunnan province, three (YN2021, YNLP 2022, YNBS 2022) one commercially available attenuated vaccine strain (Attenuated AJ1102-R) that were previously isolated sequenced compared with representative strains. NJ phylogenetic analysis showed YN2021 Attenuated CV777 clustered into GI-b subtype, while...
The heat shock factor 1 (HSF1) gene is a regulator of the stress response, maximizing HSP protein expression survival. In this research, we explored frequency distribution missense mutation (NC_037341.1 g.616087A > G, rs135258919) in HSF1 Chinese cattle with amino acid substitution, valine to alanine. This could be related tolerance Bos indicus. A total 941 individuals representing 35 native breeds, combining pure taurine (Angus) and indicine cattle, were used determine genotypes through...
Stature is an important quantitative trait for cattle performance, which influences herd productivity. Previous studies have reported that SNP (AC_000171.1:g.25015640G>T, rs109815800) in Pleomorphic adenoma gene 1 (PLAG1) on chromosome 14 (CHR14) associated with bovine stature. To validate whether rs109815800 the body height of Chinese cattle, we carried out association analysis using 558 adult samples from seven populations. Then, 1038 38 breeds were used to show geographical distribution...
The location on the Yunnan border with Myanmar and its unique cultural landscape has shaped Lincang humped cattle over time. In current study, we investigated genetic characteristics of 22 using whole-genome resequencing data. We found that derived from both Indian indicine Chinese depicted higher levels genomic diversity. Based genome-wide scans, candidate regions were identified potentially involved in local thermal humid environmental adaptions, including genes associated body size...
We report genome characterization of three native Chinese cattle breeds discovering ~34.3 M SNPs and ~3.8 InDels using whole resequencing. On average, 10.4 were shared amongst the breeds, whereas, 3.0 M, 4.9 5.8 specific to LQ, WN WS respectively. Gene ontology (GO)analysis revealed four immune response-related GO terms over represented in all samples, while two signaling pathways significantly over-represented cattle. Altogether, we found related genes (PGLYRP2, ROMO1, FYB2, CD46, TSC1)...
Copy number variation is a part of genomic structural and has caused widespread concern. According to the results high-throughput screening MLLT10 gene, we found that copy region gene was correlated with bovine growth traits. We aimed detect provide materials for Chinese yellow cattle breed. In this study, SPSS software used analyze correlation among type six different breeds (i.e., Qinchuan, Xianan, Jiaxian, Yanbian, Sinan, Yunling) corresponding The showed following: Qinchuan cattle,...
Dengchuan cattle are the only dairy yellow and endangered among Yunnan native breeds. However, its genetic background remains unclear. Here, we performed whole-genome sequencing of ten cattle. Integrating our data with publicly available data, were observed to be highly interbred than other in dataset. Furthermore, positive selective signals mainly manifested candidate genes pathways related milk production, disease resistance, growth development, heat tolerance. Notably, five (KRT39, PGR,...
Brahman cattle are tolerant to parasite challenges and heat stress. Yunling three-way hybrids that half cattle, a fourth Murray Grey Yunnan Yellow with good beef performance. The hematological biochemical parameters can reflect the physiology metabolic conditions of there valuable indicators production performance adaptability be found by studying cattle. To assess health status differences, we compared 55 28 65 using an automatic analyzer. Our results showed 27 indices were lower than those...
The majority of native cattle are taurine × indicine diverse phenotypes in the central region China. Sanjiang cattle, a typical breed region, play role human livelihood and have good adaptability, including resistance to dampness, heat, roughage, disease, thus regarded as an important genetic resource. However, history successful remains unknown. Here, we sequenced 10 genomes compared them 70 5 representative populations worldwide. We characterized genomic diversity formation process found...