A5004547905- Cancer-related molecular mechanisms research
- Genetic and phenotypic traits in livestock
- Adipose Tissue and Metabolism
- MicroRNA in disease regulation
- Genetic Mapping and Diversity in Plants and Animals
- RNA Research and Splicing
- Sirtuins and Resveratrol in Medicine
- Peroxisome Proliferator-Activated Receptors
- Meat and Animal Product Quality
- RNA modifications and cancer
- Circular RNAs in diseases
- Lipid metabolism and biosynthesis
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer-related gene regulation
- Muscle Physiology and Disorders
- Genomics and Phylogenetic Studies
- Tea Polyphenols and Effects
- Lipid metabolism and disorders
- Molecular Biology Techniques and Applications
- Epigenetics and DNA Methylation
- Effects of Environmental Stressors on Livestock
- Milk Quality and Mastitis in Dairy Cows
- Genetic diversity and population structure
- Heat shock proteins research
- Ruminant Nutrition and Digestive Physiology
Northwest A&F University
2016-2025
National Beef Cattle Industrial Technology System
2018-2025
Bambino Gesù Children's Hospital
2025
University of Milan
2025
Northwest Institute of Mechanical and Electrical Engineering
2023
Northwest College
2021
Agriculture and Forestry University
2019
Stanford University
1995
The bovine genetic resources in China are diverse, but their value and potential yet to be discovered. To determine the diversity population structure of Chinese cattle, we analyzed whole genomes 46 cattle from six phenotypically geographically representative breeds, together with 18 Red Angus genomes, 11 Japanese black taurine indicine available previous studies. Our results showed that originated hybridization between Bos taurus indicus. Moreover, found level variation depends upon degree...
Abstract Background Long non-coding RNAs (lncRNAs) regulate numerous biological processes, including adipogenesis. Research on adipogenesis will assist in the treatment of human metabolic diseases and improve meat quality livestock, such as content intramuscular fat (IMF). However, significance lncRNAs remains unclear. This research aimed to reveal transcriptomic profiles process bovine identify involved adipocytes. Results In this research, a landscape was identified with RNA-seq adipocytes...
The intramuscular fat (IMF) content of beef determined the meat quality, and market value varies with different breeds. To provide some new approaches for improving quality cattle breed improvement, 24-month-old Qinchuan (Q, n = 6), Nanyang (N, Japanese black (J, 6) were selected. IMF J group (16.92 ± 1.08%) is remarkably higher than that indigenous Chinese 13.38 1.08%, N, 12.35 1.22%). Monounsaturated fatty acids polyunsaturated in are Q creatine, lysine, glutamine three most abundant amino...
MicroRNAs (miRNAs) play crucial roles in regulating innate and adaptive immunity humans animals.Infection with E. coli or S. aureus can cause inflammation of the mammary glands, which results significant economic losses dairy cattle.However, regulatory mechanisms miRNAs response to infection bovine glands have not been thoroughly explored.To discover differential expression miRNA gland challenged aureus, we performed sequencing on tissue samples.A total 1838 were identified, including 580...
Intramuscular fat (IMF) is closely related to the tenderness, marbling, juiciness, and flavor of meat. We used a combined transcriptome metabolome analysis investigate molecular mechanisms underlying phenotypic variation among Qinchuan cattle.The IMF content was relatively high in meat cattle bulls differed muscle locations, namely rib (15.86%), ribeye (14%), striploin (10.44%), tenderloin (8.67%). CCDC80 HOX gene cluster may regulate intramuscular adipose tissue deposition. Moreover, erucic...
MicroRNAs are small, single stranded, and noncoding RNAs that have been proven to be potent regulators of adipogenesis. However, the role bta-miR-149-5p in regulating bovine adipogenesis is still unclear. Expression profiling different stages revealed was enriched proliferation stage, also on Day 9 differentiation adipocytes. Our gain function study showed can negatively regulate both adipocyte differentiation. Overexpression suppressed expression marker genes at messenger RNA (mRNA) protein...
Intramuscular preadipocyte differentiation plays a critical role in bovine intramuscular fat (IMF) deposition. However, the roles of different RNAs, including mRNAs, circRNAs, lncRNAs and miRNAs, regulating adipogenic preadipocytes remain largely unclear.In present study, whole transcriptome sequencing analysis, analysis during stages (0, 3, 6, 9 d) from Qinchuan cattle was performed. All samples were prepared with 3 biological replicates. Here, total 27,153 14,070 7035 lncRNAs, 427 miRNAs...
Riboflavin transporter deficiency syndrome (RTD) is a rare childhood-onset neurodegenerative disorder caused by mutations in SLC52A2 and SLC52A3 genes, encoding the riboflavin (RF) transporters hRFVT2 hRFVT3. In present study we focused on RTD Type 2, which due to variants gene. There no cure for patients and, although studies have reported clinical improvements with administration of RF, an effective treatment still unavailable. Here tested gene augmentation therapy type 2 patient-derived...
Recent years have witnessed a surge in the publication of dozens genome assemblies for Triticeae crops, which significantly advanced gene-related research wheat, rye, and triticale. However, this progress has also introduced challenges selecting universally efficient applicable reference genomes genotypes with distant or ambiguous phylogenetic relationships. In study, we assessed completeness accuracy triticale using comparative benchmarking universal single-copy orthologue (BUSCO) analysis...
Abstract E . coli is the main causative agent of mastitis in dairy cows, but mechanism molecular regulation underlying occurrence and development has not yet been fully elucidated. In this study, an -induced model was created RNASeq technology used to measure miRNA expression profiles at different times post-infection (0, 1, 3, 5, 7 dpi), as well screen for differentially expressed miRNA. The results show detection 2416 miRNAs, including 628 known miRNAs 1788 newly discovered miRNAs. A total...
N6-methyladenosine (m6A) plays an important role in regulating gene expression. Previous studies found that m6A methylation affects skeletal muscle development. However, the effect of methylases on bovine myogenesis is still unclear. Here, we expression demethylases (FTO and ALKBH5) was significantly higher longissimus dorsi adult cattle than newborn cattle. In contrast, methyltransferases (METTL3, METTL14 WTAP) reduced. The mRNA all five genes to be increased during myoblasts vitro....
Abstract Background Indigenous Chinese cattle have abundant genetic diversity and a long history of artificial selection, giving local breeds advantages in adaptability, forage tolerance resistance. The detection selective sweeps comparative genome analysis selected ancestral populations provide basis for understanding differences among the identification utilization candidate genes. We investigated diversity, population structure, signatures selection using genome-wide sequencing data new...
Abstract Gayal ( Bos frontalis ) is a semi-wild and endangered bovine species that differs from domestic cattle taurus indicus its genetic background remains unclear. Here, we performed whole-genome sequencing of one for the first time, with Red Angus Japanese Black as controls. In total, 97.8 Gb reads were generated an average 11.78-fold depth >98.44% coverage reference sequence (UMD3.1). Numerous different variations identified, 62.24% total single nucleotide polymorphisms (SNPs)...
Abstract The elongation of very long chain fatty acids protein 6 (ELOVL6) gene encodes a key enzyme that plays role in lipogenesis through the catalytic both saturated and monounsaturated acids. Previous studies have described high expression bovine ELOVL6 adipose tissues. However, transcriptional regulation functional lipid metabolism adipocyte proliferation remain unexplored. Here, 1.5 kb fragment 5′‐untranslated region promoter was amplified from genomic DNA Qinchuan cattle sequenced....