A5101762327- Soil erosion and sediment transport
- Cancer-related molecular mechanisms research
- Tree Root and Stability Studies
- Irrigation Practices and Water Management
- Genetic and phenotypic traits in livestock
- Radiomics and Machine Learning in Medical Imaging
- RNA modifications and cancer
- Lung Cancer Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Muscle Physiology and Disorders
- RNA Research and Splicing
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Blood Coagulation and Thrombosis Mechanisms
- Hepatitis C virus research
- Monoclonal and Polyclonal Antibodies Research
- Liver Disease Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Peptidase Inhibition and Analysis
- interferon and immune responses
- DNA Repair Mechanisms
- Animal Virus Infections Studies
- Plant responses to water stress
Northwest A&F University
2010-2025
Hebei Medical University
2008-2025
Fourth Hospital of Hebei Medical University
2011-2025
Beijing University of Agriculture
2015-2025
Beijing University of Chinese Medicine
2020-2025
National University of Mongolia
2025
Inner Mongolia University
2025
Suzhou University of Science and Technology
2024
Shaoxing People's Hospital
2010-2024
Zhumadian Central Hospital
2021-2023
Human skeletal stem cells (SSCs) have been discovered in fetal and adult long bones. However, the spatiotemporal ontogeny of human embryonic SSCs during early skeletogenesis remains elusive. Here we map transcriptional landscape limb buds bones at single-cell resolution to address this fundamental question. We found remarkable heterogeneity within bud mesenchyme epithelium, aligned them along proximal-distal anterior-posterior axes using known marker genes. Osteo-chondrogenic progenitors...
The intramuscular fat (IMF) content of beef determined the meat quality, and market value varies with different breeds. To provide some new approaches for improving quality cattle breed improvement, 24-month-old Qinchuan (Q, n = 6), Nanyang (N, Japanese black (J, 6) were selected. IMF J group (16.92 ± 1.08%) is remarkably higher than that indigenous Chinese 13.38 1.08%, N, 12.35 1.22%). Monounsaturated fatty acids polyunsaturated in are Q creatine, lysine, glutamine three most abundant amino...
Insulin-like growth factor I (IGF-1) is a key regulator of tissue and development in response to hormone stimulation. In the skeletal system, IGF-1 derived from osteoblasts chondrocytes are essential for normal bone development; however, whether marrow (BM)-resident cells provide distinct sources adult skeleton remains elusive. Here, we show that BM stromal (BMSCs) megakaryocytes/platelets (MKs/PLTs) express highest levels long bones. Deletion Igf1 BMSCs by Lepr-Cre leads decreased...
Intramuscular fat (IMF) is closely related to the tenderness, marbling, juiciness, and flavor of meat. We used a combined transcriptome metabolome analysis investigate molecular mechanisms underlying phenotypic variation among Qinchuan cattle.The IMF content was relatively high in meat cattle bulls differed muscle locations, namely rib (15.86%), ribeye (14%), striploin (10.44%), tenderloin (8.67%). CCDC80 HOX gene cluster may regulate intramuscular adipose tissue deposition. Moreover, erucic...
A new phosphine-triggered tandem [3 + 4] annulation reaction between Morita–Baylis–Hillman carbonates and 1,4-diheteroatom dinucleophiles has been developed, which provides a facile synthetic method for saturated seven-membered 1,4-heterocycles such as 1,4-oxazepanes, 1,4-thiazepanes, 1,4-diazepanes. Mechanistic investigation implies that this takes place through phosphine-catalyzed allylic alkylation followed by general base-catalyzed intramolecular Michael cyclization.
The development of hair follicle in cashmere goats shows significant periodic change, as with mice and humans. However, for goat double-coat, the change may be due to other regulatory molecules signal pathways. To understand mechanism follicle, we performed a weighted gene coexpression network analysis (WGCNA) mine key genes establish an interaction by utilizing NCBI public dataset. Ten modules, including 7689 protein-coding genes, were constructed WGCNA, six which are considered...
The intramuscular fat (or marbling fat) content is an essential economic trait of beef cattle and improves the flavor palatability meat. Several studies have highlighted correlation between long non-coding RNAs (lncRNAs) development; however, precise molecular mechanism remains unknown. Previously, through a high-throughput sequencing analysis, we found lncRNA named it RNA BNIP3 (lncBNIP3). 5′ RACE 3′ explored 1945 bp total length lncBNIP3, including 1621 5′RACE, 464 3′RACE. nucleoplasmic...
N6-methyladenosine (m6A) plays an important role in regulating gene expression. Previous studies found that m6A methylation affects skeletal muscle development. However, the effect of methylases on bovine myogenesis is still unclear. Here, we expression demethylases (FTO and ALKBH5) was significantly higher longissimus dorsi adult cattle than newborn cattle. In contrast, methyltransferases (METTL3, METTL14 WTAP) reduced. The mRNA all five genes to be increased during myoblasts vitro....
Hard carbons derived from coal precursors have shown bright industrial prospect as the low cost anode materials of sodium‐ion batteries. However, it is extreme necessity yet challenge to regulate carbon microstructure toward superior sodium energy storage. In this study, we propose a powerful chemical reconfiguration tactic steer hard high‐capacity and fast The functional species on edge/plane terminals bituminous are finely reconfigured by nitri‐oxidation treatment for effectively...
Hard carbons derived from coal precursors have shown bright industrial prospect as the low cost anode materials of sodium‐ion batteries. However, it is extreme necessity yet challenge to regulate carbon microstructure toward superior sodium energy storage. In this study, we propose a powerful chemical reconfiguration tactic steer hard high‐capacity and fast The functional species on edge/plane terminals bituminous are finely reconfigured by nitri‐oxidation treatment for effectively...
Iris domestica is a perennial herb valued for both its ornamental and medicinal properties. Despite significance, no comprehensive analysis of mitochondrial genome has been previously reported. Plant genomes are known their large size, structural complexity, frequent recombination events. This study aims to provide the first complete assembly characterization I. domestica, with focus on structure, gene content, repeat elements, RNA editing sites. We used GetOrganelle Unicycler software...