A5101914962- Advanced Sensor and Energy Harvesting Materials
- Mesenchymal stem cell research
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Microfluidic and Bio-sensing Technologies
- MicroRNA in disease regulation
- Pancreatic function and diabetes
- Venous Thromboembolism Diagnosis and Management
- Extracellular vesicles in disease
- Single-cell and spatial transcriptomics
- Phagocytosis and Immune Regulation
- Zebrafish Biomedical Research Applications
- Cancer Genomics and Diagnostics
- Advanced Materials and Mechanics
- Lipid metabolism and disorders
- Immune cells in cancer
- Vibration Control and Rheological Fluids
- Fire dynamics and safety research
- Micro and Nano Robotics
- Caveolin-1 and cellular processes
- Blood Coagulation and Thrombosis Mechanisms
- Structural Response to Dynamic Loads
- Microfluidic and Capillary Electrophoresis Applications
- Circular RNAs in diseases
- Soft Robotics and Applications
University of Science and Technology of China
2022-2024
University of Alabama at Birmingham
2017-2024
Birmingham VA Medical Center
2022-2024
North China University of Science and Technology
2022-2024
National University of Singapore
2021-2022
Southern University of Science and Technology
2021-2022
Shanghai Tenth People's Hospital
2017-2021
Tongji University
2017-2021
Fullerton College
2018
East Tennessee State University
2014
Human skeletal stem cells (SSCs) have been discovered in fetal and adult long bones. However, the spatiotemporal ontogeny of human embryonic SSCs during early skeletogenesis remains elusive. Here we map transcriptional landscape limb buds bones at single-cell resolution to address this fundamental question. We found remarkable heterogeneity within bud mesenchyme epithelium, aligned them along proximal-distal anterior-posterior axes using known marker genes. Osteo-chondrogenic progenitors...
Stretchable configuration occupies priority in devising flexible conductors used intelligent electronics and implantable sensors. While most conductive configurations cannot suppress electrical variations against extreme deformation ignore inherent material characteristics. Herein, a spiral hybrid fiber (SHCF) composed of aramid polymeric matrix silver nanowires (AgNWs) coating is fabricated through shaping dipping processes. The homochiral coiled mimicked by plant tendrils not only enables...
Multipotent human adipose-derived stromal/stem cells (hADSCs) hold a great promise for cell-based therapy many devastating diseases, such as spinal cord injury and stroke. If exogenous hADSCs can be cultured in three-dimensional (3D) scaffold with effective proliferation differentiation capacity, it will better mimic the vivo environment, which have profound impact on therapeutic application of hADSCs. In this study, group elastic-dominant, porous bioscaffolds from photocurable chitosan...
Sexually dimorphic tissues are formed by cells that regulated sex hormones. While a number of systemic hormones and transcription factors known to regulate proliferation differentiation osteoblasts osteoclasts, the mechanisms determine sexually differences in bone regeneration unclear. To explore how regeneration, we compared fracture repair between adult male female mice. We found skeletal stem cell (SSC) mediated mice is dependent on estrogen signaling but SSCs from do not exhibit similar...
The soft actuators capable of responding to multiple stimuli and adapting changing environments have attracted growing interest in the flexible multifunctional materials. However, how achieve high degree freedom (DoF), precise control, complex shape transformation multi-stimuli responsive actuator, still remains challenging. Here, we report a multi-responsive actuator with various controllable sophisticated deformations by integrating magnetically sensitive elastomer (MSE) liquid crystal...
The small intestine generally transports dietary fats to circulation in triglyceride (TG)-rich lipoproteins. two main intestinal lipoproteins are chylomicron (CM) and very low-density lipoprotein (VLDL). Unfortunately, studies on the CM biogenesis transport of have been hampered by lack an adequate vitro model. In this study, we investigated possible factors that might increase efficiency production Caco-2 cells. We utilized sequential NaCl gradient ultracentrifugation isolate CMs were...
Background Circulating microRNAs are emerging biomarkers for heart failure (HF). Our study aimed to assess the prognostic value of microRNA signature that is differentially expressed in patients with acute HF. Methods and Results comprised a screening cohort 15 AHF 5 controls, PCR-discovery 50 26 controls validation 564 from registered DRAGON-HF (Diagnostic, Risk Stratification Prognostic Value Novel Biomarkers Patients With Heart Failure). Through by RNA-sequencing verification...
Density-gradient centrifugation is a label-free approach that has been extensively used for cell separations. Though elegant, this process time-consuming (>30 min), subjects cells to high levels of stress (>350 g) and relies on user skill enable fractionation layer as narrow band between the density-gradient medium platelet-rich plasma. We hypothesized microfluidic adaptation technique could transform into rapid where samples are separated in continuous fashion while being exposed lower...
The poor prognosis for patients with hepatocellular carcinoma (HCC) is related directly to metastasis. Twist1 gene encodes a transcription factor essential embryogenesis. It has also been shown promote epithelial-to-mesenchymal transition (EMT), invasion, and metastasis; however, there currently no in vivo evidence that plays role the metastasis of liver tumors. Zebrafish are increasingly being used as an alternative cancer model. In current study, adult-stage zebrafish HCC model was examine...
It has previously been demonstrated that the renin-angiotensin system is involved in pathogenesis and development of pulmonary hypertension (PH). However, efficacy angiotensin II type I (AT1) receptor blockers treatment PH variable. The present study examined effects AT1 blocker valsartan on monocrotaline (MCT)‑induced rats chronic hypoxia‑induced mice. results markedly attenuated mice, as indicated by reduced right ventricular systolic pressure, diminished lung vascular remodeling decreased...
Intestinal carcinogenesis is a multistep process that begins with epithelial hyperplasia, followed by transition to an adenoma and then carcinoma. Many etiological factors, including KRAS mutations inflammation, have been implicated in oncogenesis. However, the potential synergistic effects between inflammation as well mechanisms which they promote intestinal remain unclear. Thus, objective of this study was investigate krasV12, lipopolysaccharides (LPS), and/or dextran sulfate sodium (DSS)...
The poor prognosis of patients diagnosed with hepatocellular carcinoma (HCC) is directly associated the multi-step process tumor metastasis. TWIST1, a basic helix-loop-helix (bHLH) transcription factor, most important epithelial-mesenchymal transition (EMT) gene involved in embryonic development, progression, and However, role that TWIST1 plays liver metastasis vivo still not well understood. Zebrafish can serve as powerful model for cancer research. Thus, this study, we crossed twist1a+...
The crosstalk between tumors and their local microenvironment has been well studied, whereas the effect of on distant tissues remains understudied. Studying how affect other is important for understanding systemic improving overall health cancer patients. In this study, we focused changes in intestine during liver tumor progression, using a previously established model through inducible expression oncogene xmrk zebrafish. Progressive disruption intestinal structure was found fish, displaying...
Abstract Human skeletal stem cells (SSCs) have been discovered in fetal and adult bones. However, the spatiotemporal ontogeny of human SSCs during embryogenesis has elusive. Here we map transcriptional landscape embryonic skeletogenesis at single-cell resolution to address this fundamental question. We found remarkable heterogeneity within limb bud mesenchyme epithelium, as well earliest osteo-chondrogenic progenitors. Importantly, (eSSCs) were perichondrium long bones, which self-renew...
Prostate cancer has the second highest incidence among male malignancies. Only a few studies exist on inhibitory effects of maslinic acid (MA) prostate cancer. Herein we found that MA inhibits cell proliferation by decreasing CDK2, CDK4, and CDK6 expression concurrently increasing p27, Rb, p-Rb expression. Further, was observed to induce autophagy p53, p-p53, ULK1, Beclin1, Atg7, Atg5 ratio LC3-II/I ERK1/2 mTOR. In addition, induced RM-1 ferroptosis regulating glutathione, glutamate,...