A5081215870- Mesenchymal stem cell research
- Peptidase Inhibition and Analysis
- Plant Gene Expression Analysis
- Cancer Genomics and Diagnostics
- Essential Oils and Antimicrobial Activity
- Genetic factors in colorectal cancer
- Growth Hormone and Insulin-like Growth Factors
- Ginseng Biological Effects and Applications
- Plant Reproductive Biology
- Cellular Mechanics and Interactions
- Gut microbiota and health
- Adipose Tissue and Metabolism
- Renal cell carcinoma treatment
- TGF-β signaling in diseases
- Microplastics and Plastic Pollution
- Graphene and Nanomaterials Applications
- Signaling Pathways in Disease
- Natural product bioactivities and synthesis
- Nanoparticles: synthesis and applications
- Hematopoietic Stem Cell Transplantation
- Cardiac Structural Anomalies and Repair
- Cancer Cells and Metastasis
- Advanced Measurement and Detection Methods
- Neuropeptides and Animal Physiology
- MicroRNA in disease regulation
Zhejiang Chinese Medical University
2025
Hebei University
2025
Annoroad Gene Technology (China)
2024
Shanghai East Hospital
2021-2023
Xinjiang Medical University
2020
Jiangsu University
2012
Abstract Fibroblast activation protein (Fap) is a serine protease that degrades denatured type I collagen, α2-antiplasmin and FGF21. Fap highly expressed in bone marrow stromal cells functions as an osteogenic suppressor can be inhibited by the growth factor Osteolectin (Oln). also synovial fibroblasts positively correlated with severity of rheumatoid arthritis (RA). However, whether plays critical role osteoarthritis (OA) remains poorly understood. Here, we found significantly elevated...
Myocardial infarction (MI) elicits cardiac fibroblast activation and extracellular matrix (ECM) deposition to maintain the structural integrity of heart. Recent studies demonstrate that Fap (fibroblast protein)-a prolyl-specific serine protease-is an important marker activated fibroblasts after MI.Left ventricle plasma samples from patients healthy donors were used analyze expression level FAP its prognostic value. Echocardiography histological analysis heart sections functions, scar...
Insulin-like growth factor I (IGF-1) is a key regulator of tissue and development in response to hormone stimulation. In the skeletal system, IGF-1 derived from osteoblasts chondrocytes are essential for normal bone development; however, whether marrow (BM)-resident cells provide distinct sources adult skeleton remains elusive. Here, we show that BM stromal (BMSCs) megakaryocytes/platelets (MKs/PLTs) express highest levels long bones. Deletion Igf1 BMSCs by Lepr-Cre leads decreased...
Abstract Background Early detection of colorectal cancer (CRC) significantly enhances patient outcomes. Conventional CRC screening tools, like endoscopy and stool-based tests, have constraints due to their invasiveness or suboptimal adherence. Recently, liquid biopsy employing plasma cell-free DNA (cfDNA) has emerged as a potential noninvasive technique for various malignancies. Methods In this research, we harnessed the Mutation Capsule Plus (MCP) technology profile an array genomic...
Abstract A distinct population of skeletal stem/progenitor cells (SSPCs) has been identified that is indispensable for the maintenance and remodeling adult skeleton. However, cell types are responsible age-related bone loss characteristic changes in these during aging remain to be determined. Here, we established models premature by conditional depletion Zmpste24 ( Z24 ) mice found Prx1- dependent deletion, but not Osx- caused significant loss. Acan -associated only trabecular Single-cell...
Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease and increasing evidence suggests that disturbances in the composition function of gut microbiota are potentially implicated progression RA. Further revealing related metabolic disorders preclinical stage RA (pre-RA) great significance for exploration mechanisms. Methods: DBA/1 mice were injected with type II collagen on days 0 21 to establish collagen-induced (CIA) mouse model. Footpad thickness, serum autoantibodies,...
Background Niraparib, a poly ADP-ribose polymerase inhibitors (PARPi), has been widely applied in the intervention of epithelial ovarian, fallopian tube, or primary peritoneal cancer. Nevertheless, as present moment, there are limited instances demonstrating favorable outcomes stemming from niraparib therapy patients with clear cell renal carcinoma (ccRCC). Case presentation Here, we report case 50-year-old patient ccRCC who subsequently developed distant metastasis. The received monotherapy...
In order to solve the self-occlusion problem in plane-based multi-camera calibration system and expand measurement range, a tri-camera vision based on binocular is proposed. The three cameras are grouped into two pairs, while public camera taken as reference build global coordinate. By of measured absolute distance true distance, realized. MRE (mean relative error) pairs experiments can be low 0.277% 0.328% respectively. Experiment results show that this method feasible, simple effective,...
To investigate the transnasal absorption characteristics of Cistanche deserticola phenylethanol glycosides nanoemulsion and its influencing factors. With use classic in vivo nasal circulation perfusion model rats, rate constant was used as index to compare C. aqueous solution different concentrations, explore effects pH value preparation accelerator Azone on nanoemulsion. The results showed that, compared with group, significantly higher same concentration(P<0.05), more easily absorbed by...