A5030943448- Ubiquitin and proteasome pathways
- Inflammasome and immune disorders
- Inflammatory mediators and NSAID effects
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Galectins and Cancer Biology
- Medicinal Plant Pharmacodynamics Research
- NF-κB Signaling Pathways
- Hair Growth and Disorders
- interferon and immune responses
- Osteoarthritis Treatment and Mechanisms
81th Hospital of PLA
2023
Northwest A&F University
2021
The development of hair follicle in cashmere goats shows significant periodic change, as with mice and humans. However, for goat double-coat, the change may be due to other regulatory molecules signal pathways. To understand mechanism follicle, we performed a weighted gene coexpression network analysis (WGCNA) mine key genes establish an interaction by utilizing NCBI public dataset. Ten modules, including 7689 protein-coding genes, were constructed WGCNA, six which are considered...
Abstract Several members of the ubiquitin-specific proteases (USPs) family have been revealed to regulate progression osteoarthritis (OA). The current study aimed investigate role and underlying mechanism USP25 in IL-1β-induced chondrocytes OA rat model. It was discovered that IL-1β stimulation upregulated USP25, increased ROS level, suppressed cell viability chondrocytes. Besides, knockdown alleviated injury by decreasing attenuating pyroptosis, downregulating expression IL-18, NLRP3,...
Osteoarthritis (OA) is a cartilage degenerative disease commonly observed in the elderly population and significantly impacts normal life of OA patients. It has been reported that development pathological cell senescence chondrocytes involved pathogenesis OA. Celecoxib common non-steroidal anti-inflammatory drug, it recently to exert therapeutic effects on However, its underlying mechanism still unclear. The present study intends explore provide fundamental evidence for application treatment...