A5073945062- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Cervical Cancer and HPV Research
- Peripheral Neuropathies and Disorders
- Bacterial Infections and Vaccines
- Pneumonia and Respiratory Infections
- Autoimmune Neurological Disorders and Treatments
- Birth, Development, and Health
- Ferroptosis and cancer prognosis
- Axon Guidance and Neuronal Signaling
- Genomic variations and chromosomal abnormalities
- Streptococcal Infections and Treatments
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Pediatric Hepatobiliary Diseases and Treatments
- Antibiotic Resistance in Bacteria
- Nerve injury and regeneration
- Fetal and Pediatric Neurological Disorders
- Medical Imaging Techniques and Applications
- vaccines and immunoinformatics approaches
- Neuroendocrine regulation and behavior
Chongqing Medical University
2016-2025
Children's Hospital of Chongqing Medical University
2016-2025
Shandong University
2022-2025
China International Science and Technology Cooperation
2017-2023
Xi'an Jiaotong University
2020-2023
Linyi People's Hospital
2015-2022
Qilu Hospital of Shandong University
2017-2022
Guangzhou University of Chinese Medicine
2021
Wuhan Medical Center for Women and Children
2013-2019
Qingdao University
2019
Abstract Introduction Fine particulate matter (PM2.5) is closely associated with many neurological disorders including neurodegenerative disease, stroke, and brain tumors. However, the toxic effects of PM2.5 on neurodevelopment remain unclear. In this study, we aimed to determine neurotoxic early postnatal exposure in immature mature rats. Methods We exposed neonatal rats (2 or 10 mg/kg body weight) through intranasal instillation from day (PND) 3–15, once a day. Emotional cognitive...
ObjectiveNeoadjuvant chemotherapy (NACT) for cervical cancer still remains controversial. NACT was evaluated to establish selection criteria.MethodsA matched-case comparison designed the group (n = 707) and primary surgery treatment (PST; n investigate short-term responses high/intermediate risk factors (HRFs/IRFs). The 5-year disease-free survival (DFS) overall (OS) rates were stratified by response, HRFs/IRFs, International Federation of Gynecology Obstetrics (FIGO) stage tumour size,...
Abstract Objective To evaluate the diagnostic value of combination detection serum cancer antigen 125 (CA125), carbohydrate 19-9 (CA199) and carci noembryonic antigen(CEA) in patients with epithelial ovarian by pooling open published studies according to meta-analysis method. Methods Diagnostic related CA125, CA199 CEA were electronic searched databases PubMed, Cochrane, Google scholar, EMBASE, ISI Web Knowledge CNKI two independent reviewers. The combined sensitivity, specificity, positive...
Objective To facilitate the accurate identification of clinical characteristics associated with myelin oligodendrocyte glycoprotein (MOG) antibody positive encephalitis in children presenting normal brain magnetic resonance imaging (MRI) findings. Method Patients hospitalized at Children’s Hospital Chongqing Medical University from January 2016 to May 2024, who were for MOG antibodies and exhibited symptoms MRI findings, retrospectively analyzed. Results A total 17 patients (7 males 10...
Abstract Background Expanding noninvasive prenatal testing (NIPT) to include the detection of fetal subchromosomal copy number variations (CNVs) significantly decreased sensitivity and specificity. Developing analytic pipeline achieve high performance in CNVs will largely contribute application screening clinical practice. Methods We developed Noninvasively Prenatal Subchromosomal Copy variation Detection (NIPSCCD) method based on low‐pass whole‐genome sequencing, evaluated its efficacy...
Abstract Embryo culture conditions are crucial as they can affect embryo quality and even offspring. Oviductal extracellular vesicles (EVs) long been considered a major factor influencing interactions between the oviduct embryos, thus its absence is associated with inferior embryonic development in vitro culture. Herein, we demonstrated that melatonin present fluids fluid‐derived EVs. Addition of either EVs (1.87 × 10 11 particles/mL) or (340 ng/mL) led to significant downregulation reactive...
Background Human papillomaviruses ( HPV s) are strongly associated with the development of cervical carcinoma, and distribution genotypes varies regionally. Methods To investigate characteristics different infection in women Wuhan, China, a total 13 775 patients were enrolled over 2 years. Results Of these, 2436 infected s, rate was 17.68%. The high‐risk HR ‐ ) significantly higher (13.96%) than that single low‐risk LR ; 3.72%). Among infections, most common genotype 52 an 4.23%, followed by...
Background The purpose of this study is to elucidate the association between α‐synuclein ( SNCA ) polymorphisms and risk Alzheimer's disease AD ). Methods PCR ‐ RFLP was applied detect gene rs6532190, rs3775430, rs10516846 in 98 patients 105 healthy elderly. Results GG frequency evidently increased group than control P < 0.05). There a significant difference level groups 0.01). In group, cerebrospinal fluid (rs10516846) carriers as compared with AA early‐onset significantly higher that...
Abstract Background The noninvasive prenatal testing (NIPT) has been successfully used in the clinical screening of fetal trisomy 13, 18, and 21 last few years researches on detecting sub‐chromosomal copy number variations (CNVs) monogenic diseases are also progress. To date, multiple tests needed order to complete a full set fetus disorder screening, which is costly time consuming. Therefore, an integrated 3‐in‐1 NIPT approach will be great demand by routine practice near future. Methods We...
Dysbiosis of the lower airway flora is associated with lung cancer, which relationship between Streptococcus, especially pathogenic Streptococcus pneumoniae (S. pneumoniae), and progression cancer are unclear.Bronchoalveolar lavage fluid (BALF) samples were prospectively collected from patients pulmonary nodules during diagnostic bronchoscopy, finally included 70 diagnosed primary 20 benign as disease control group. The differential was screened by 16S ribosomal RNA (rRNA) gene amplicon...
Abstract Purpose This study aimed to investigate whether minocycline could influence alterations of microglial subtypes, the morphology dendrites and dendritic spines, microstructures synapses synaptic proteins, or even cognition outcomes in immature male mice following status epilepticus (SE) induced by kainic acid. Methods Golgi staining was performed visualize spines neurons hippocampus. The proteins were observed using transmission electron microscopy western blotting analysis,...
BACKGROUND The present study aimed to compare the clinical efficacy and safety of uterine artery embolization (UAE) vs. laparoscopic cesarean scar pregnancy debridement surgery (LCSPDS) in treatment patients with (CSP). MATERIAL AND METHODS A retrospective analysis was performed on 87 CSP from March 2012 February 2017. For included cases, 51 were treated UAE 36 LCSPDS. operation success rate, intraoperative blood loss, time, length hospital stay, perioperative complications, β-HCG level...
Selenium-containing protein from selenium-enriched Spirulina platensis (Se-SP) (syn. Arthrospira [Microcoleaceae]) showed novel antioxidant activity. However, the protective effect of Se-SP against oxygen glucose deprivation (OGD)-induced neural apoptosis has not been reported yet.To verify whether can inhibit OGD-induced and explore underlying mechanism.Primary hippocampal neurons were separated Sprague-Dawley (SD) rats. 95% N2 + 5% CO2 employed to establish OGD model. Neurons treated with...
Background: This study aimed to establish a nomogram by combining clinicopathologic factors with overall survival of stage IA-IIB cervical cancer patients after complete resection pelvic lymphadenectomy. Materials and Methods: was based on retrospective 1,563 who underwent lymphadenectomy from 2002 2008. The constructed multivariate analysis using Cox proportional hazard regression. accuracy discriminative ability the were measured concordance index (C-index) calibration curve. Results:...
Abstract Cervical cancer (CC) is known as one of the most common gynecological tumors. Long noncoding RNAs (lncRNAs) are a group regulators that have been widely reported in human malignant tumors including CC. On basis data The Cancer Genome Atlas, lncRNA DDN and PRKAG1 antisense RNA 1 ( DDN‐AS1 ) overexpressed CC tissues predicted poor prognosis for patients with Moreover, quantitative reverse transcription PCR analysis further identified upregulation cell lines. Loss‐of‐function assays...
Abstract Despite remarkable advances in epilepsy research, prevention and reversal of cognitive deficits following remain a challenge. It was reported that the Rho kinase (ROCK) inhibitor fasudil hydrochloride (FH) could improve animal models Alzheimer’s disease (AD). Thus, aim present study to determine whether FH–mediated inhibition effects ROCK signaling male rats (postnatal 21‐day old) status epilepticus (SE) induced by lithium‐pilocarpin, therapeutic window opportunity elucidate...
To study the alteration of microglial subtypes, representative markers microglia, and morphology dendrites dendritic spines after acute status epilepticus (SE) during recurrent seizures.A mouse kainate-induced SE model was used. Dendrites granule neurons in dentate gyrus (DG) subregion pyramidal cornu ammonis (CA)1 (CA)3 subregions hippocampus were visualized by Golgi staining. Synaptic proteins evaluated Western blot analysis, microglia their flow cytometry.Extensive partial spine loss...
Accumulated evidence shows that elevated urotensin II (UII) levels are associated with cardiovascular diseases. However, the role of UII in initiation, progression, and regression atherosclerosis remains to be verified. Different stages were induced rabbits by a 0.3% high cholesterol diet (HCD) feeding, either (5.4 μg/kg/h) or saline was chronically infused via osmotic mini-pumps. promoted atherosclerotic fatty streak formation ovariectomized female (34% increase gross lesion 93% microscopic...