A5101681134- Monoclonal and Polyclonal Antibodies Research
- Protein purification and stability
- CAR-T cell therapy research
- Nitrogen and Sulfur Effects on Brassica
- Immune cells in cancer
- Biosimilars and Bioanalytical Methods
- Multiple Myeloma Research and Treatments
- Yersinia bacterium, plague, ectoparasites research
- Liver Disease Diagnosis and Treatment
- Plant Reproductive Biology
- Inflammasome and immune disorders
- Photosynthetic Processes and Mechanisms
- Glycosylation and Glycoproteins Research
- HER2/EGFR in Cancer Research
- Parasitic Infections and Diagnostics
- Toxin Mechanisms and Immunotoxins
- Autophagy in Disease and Therapy
- Immunotherapy and Immune Responses
- Aortic aneurysm repair treatments
- Computational Drug Discovery Methods
- Pharmacogenetics and Drug Metabolism
- Heme Oxygenase-1 and Carbon Monoxide
- Advanced Proteomics Techniques and Applications
- Histone Deacetylase Inhibitors Research
- Ubiquitin and proteasome pathways
Janssen (United States)
2015-2024
Tianjin Medical University General Hospital
2024
Tianjin Medical University
2024
Xi'an Jiaotong University
2014-2023
Ministry of Agriculture and Rural Affairs
2023
Shanghai Academy of Agricultural Sciences
2021-2023
Oil Crops Research Institute
2023
Jilin University
2018-2021
Shanghai Jiao Tong University
2021
Chinese Academy of Sciences
2021
In this report, the utility of a commonly used interspecies scaling method to predict systemic clearance (CL) therapeutic proteins in humans was evaluated. Based on analysis pharmacokinetic data set 34 proteins, including 12 monoclonal antibodies (mAbs) and Fc fusion human CL can generally be predicted reasonably well with simple allometric fixed exponent 0.8: approximately 95% cases values within 2-fold observed when using from multiple species, or 90% simply monkeys. Specific mAbs/Fc...
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a promising therapeutic target for treating coronary heart disease. We report novel antibody 1B20 that binds to PCSK9 with sub-nanomolar affinity and antagonizes function in-vitro. In CETP/LDLR-hemi mice two successive doses of 1B20, administered 14 days apart at 3 or 10 mpk, induced dose dependent reductions in LDL-cholesterol (≥ 25% 7-14 days) correlated well the extent occupancy by antibody. addition, induces increases total plasma...
The mechanism underlying subcutaneous absorption of macromolecules and factors that can influence this process were studied in rats using PEGylated erythropoietins (EPOs) as model compounds. Using a thoracic lymph duct cannulation (LDC) model, we showed EPO was absorbed from the injection site mainly via lymphatic system rats, which is similar to previous reports sheep. After administration, serum exposure reduced by ∼70% LDC animals compared with control animals, most systemically available...
Coronavirus disease 2019 (COVID-19) has caused a crisis to global public health since its outbreak at the end of 2019. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), pathogen COVID-19, appears efficiently evade host immune responses, including interferon (IFN) signaling. Several SARS-CoV-2 viral proteins are believed involve in inhibition IFN In this study, we discovered that ORF3a, an accessory protein SARS-CoV-2, inhibited IFN-activated Janus kinase (JAK)/signal transducer...
Abstract FR104 is a monovalent pegylated Fab′ Ab, antagonist of CD28, under development for treatment transplant rejection and autoimmune diseases. In contrast to CD80/86 antagonists (CTLA4-Ig), selectively blunts CD28 costimulation while sparing CTLA-4 PD-L1 coinhibitory signals. the present work, has been evaluated in first-in-human study evaluate safety, pharmacokinetics, pharmacodynamics, potency i.v. administrations healthy subjects. Sixty-four subjects were randomly assigned four...
T-cell redirecting bispecific antibodies (bsAbs) or antibody-derived agents that combine tumor antigen recognition with CD3-mediated T cell recruitment are highly potent tumor-killing molecules. Despite the tremendous progress achieved in last decade, development of such bsAbs still faces many challenges. This work aimed to develop a mechanism-based pharmacokinetic/pharmacodynamic (PK/PD) modeling framework can be used assist bsAbs. A Target cell-Biologics-Effector (TBE) complex-based...
SIRT1, a highly conserved NAD+-dependent protein deacetylase, plays pivotal role in the pathogenesis and therapy of atherosclerosis (AS). The aim this study is to investigate potential effects SIRT1 on AS ApoE-/- mice underlying mechanisms autophagy an ox-LDL-stimulated human monocyte cell line, THP-1. In vivo, accelerated atherosclerotic progression was established by carotid collar placement; then, were treated for 4 weeks with SIRT1-specific inhibitor, EX-527. lesion size EX-527-treated...
Abstract CD33 is expressed in 90% of patients with acute myeloid leukemia (AML), and its extracellular portion consists a V domain C2 domain. A recent study showed that single nucleotide polymorphism (SNP), rs12459419 (C > T), results the reduced expression domain–containing limited efficacy domain–binding anti-CD33 antibodies. We developed JNJ-67571244, novel human bispecific antibody capable binding to CD3, induce T-cell recruitment CD33+ tumor cell cytotoxicity independently their...
Abstract Background Rabbits are well-domesticated animals. As a crucial economic animal, rabbit has been successfully bred into wool-use, meat-use and fur-use breeds. Hair length is one of the most economically important traits affecting profitability in wool rabbits. In this study, to identify selection signatures with long-hair trait, whole-genomic resequencing long-haired rabbits (Angora rabbits) short-haired (Rex New Zealand was performed. Results By genome-wide selective sweeping...
Objectives: Teclistamab (tec), the first approved B-cell maturation antigen × CD3 bispecific antibody (BsAb) with weight-based dosing for treatment of patients (pts) triple-class exposed relapsed/refractory multiple myeloma (RRMM). Within MajesTEC-1 study (NCT03145181/NCT04557098)1-3, phase 1 exploratory prophylactic tocilizumab (toci) cohort previously demonstrated that a single dose toci (administered up to 4 hrs before step-up (SUD) (tec)) reduced overall incidence cytokine release...
The Himalayan marmot (Marmota himalayana) is a hibernating mammal that inhabits the high-elevation regions of mountains. Here we present draft genome marmot, with total assembly length 2.47 Gb. Phylogenetic analyses showed diverged from Mongolian approximately 1.98 million years ago. Transcriptional changes during hibernation included genes responsible for fatty acid metabolism in liver and involved complement coagulation cascades stem cell pluripotency pathways brain. Two selective sweep...
Dapagliflozin, a sodium glucose transporter protein-2 (SGLT-2) inhibitor, reduces the risk for cardiovascular diseases. However, influence of dapagliflozin on nondissecting abdominal aortic aneurysms (AAAs) remains unclear. AAAs were created in male C57BL/6 mice via intra-aortic porcine pancreatic elastase (PPE) infusion. Mice daily treated with (1 or 5 mg/kg body weight) an equal volume vehicle through oral gavage beginning one day prior to PPE infusion 14 days. To investigate its...