A5101413431- Schizophrenia research and treatment
- Pharmaceutical studies and practices
- Glaucoma and retinal disorders
- Chemotherapy-induced organ toxicity mitigation
- Ocular Diseases and Behçet’s Syndrome
- Ophthalmology and Visual Impairment Studies
- Intraocular Surgery and Lenses
- Retinal Imaging and Analysis
- Pharmacological Effects and Toxicity Studies
- Health Systems, Economic Evaluations, Quality of Life
- Neuroendocrine Tumor Research Advances
- Pediatric health and respiratory diseases
- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Ocular Infections and Treatments
- Mental Health and Psychiatry
- Folate and B Vitamins Research
- Acute Lymphoblastic Leukemia research
- Infant Nutrition and Health
- Salivary Gland Tumors Diagnosis and Treatment
- Antibiotics Pharmacokinetics and Efficacy
- Obsessive-Compulsive Spectrum Disorders
- IgG4-Related and Inflammatory Diseases
- Nasolacrimal Duct Obstruction Treatments
- Opioid Use Disorder Treatment
Tzu Chi Foundation
2022-2024
Westmead Institute
2023
Buddhist Tzu Chi Medical Foundation
2023
Takeda (United States)
2017-2023
Banner - University Medical Center Tucson
2022
University of Arizona
2022
Cedars-Sinai Medical Center
2021
Hualien Tzu Chi Medical Center
2021
Merck & Co., Inc., Rahway, NJ, USA (United States)
2012-2020
Vale (Canada)
2012-2020
This study aimed to evaluate the abuse potential and cognitive effects of nabiximols (Sativex, GW Pharma Ltd. Salisbury, UK), an oromucosal spray primarily containing delta‐9‐tetrahydrocannabinol (THC) cannabidiol (CBD).This was a single‐dose, randomized, double‐blind, crossover comparing (4, 8, 16 consecutive sprays: 10.8, 21.6, 43.2 mg THC, respectively) with dronabinol 20 40 (synthetic THC: Marinol, Solvay Pharmaceuticals, Brussels, Belgium) matching placebos in 23 recreational cannabis...
The mechanism underlying subcutaneous absorption of macromolecules and factors that can influence this process were studied in rats using PEGylated erythropoietins (EPOs) as model compounds. Using a thoracic lymph duct cannulation (LDC) model, we showed EPO was absorbed from the injection site mainly via lymphatic system rats, which is similar to previous reports sheep. After administration, serum exposure reduced by ∼70% LDC animals compared with control animals, most systemically available...
The clinical need to address stress and depression in Latino dementia caregivers (CGs) combined with low health literacy less accurate knowledge of motivated the development a pictorial tool [called fotonovela (FN)] teach (a) coping skills for caregiver (CG) stress; (b) self-assessment depression; (c) encourage improved utilization available resources. To test effectiveness FN, 110 147 CGs, who were randomly assigned Fotonovela Condition (FNC) or Usual Information (UIC), included final...
Paecilomyces lilacinus is a fungal pathogen which generally resistant to amphotericin B and certain other antifungals an uncommon cause of devastating keratitis. In the present studies, we evaluated topical voriconazole as therapy for P. keratitis in rabbits. Thirty eyes 15 rabbits were studied. five animals, uninfected left eye was treated twice daily with (drug control, eye). these same right infected but not (infection control By day 5, infection controls had lesions >2.4 mm diameter,...
The neonatal Fc receptor (FcRn) plays a pivotal role in IgG homeostasis, i.e., it salvages antibodies from lysosomal degradation following fluid-phase pinocytosis, thus preventing rapid systemic elimination of IgG. Recombinant therapeutic are typically composed human or humanized sequences, and their biodistribution, tissue distribution, is often studied murine models, although, the effect FcRn on distribution rodents has not been investigated. In this report, an 125I-labeled IgG1 antibody...
Objectives The aim of this study was to compare the effects an infant formula fortified with nucleotides (NF) those a control (CF) on incidence diarrhea, respiratory tract infections (RTIs), and immune responses in healthy term infants. Methods This 12-month, double-blind conducted 1- 7-day-old infants randomized receive NF or CF exclusively until 12 weeks age, fed assigned solid food months. supplemented 72 mg/L nucleotides, based total potentially available nucleotide content human milk....
Ifosfamide (IFO), which is used in the treatment of pediatric solid tumors, causes high rates nephrotoxicity. N-acetylcysteine (NAC), an antidote for acetaminophen overdose, has been shown to prevent IFO-induced renal cell death and nephrotoxicity both LLCPK-1 cells a rat model. To facilitate use NAC preventing children, authors compared systemic exposure children treated overdose therapeutically effective The mean model was 18.72 mM·h (range, 9.92-30.02 mM·h), found (14.48 mM·h; range,...
Vitamin B12 plays an essential role in fetal and infant development. In regions where animal source food consumption is low perinatal supplementation uncommon, infants are at risk of vitamin deficiency. this secondary analysis, we measured total concentrations maternal serum/plasma breast milk among two samples mother-infant dyads Canada (assessed 8 weeks post-partum) Cambodia between 3-27 post-partum). Canadian mothers (n = 124) consumed a daily B12-containing multiple micronutrient...
Insulin resistance is often associated with obesity. We tested whether augmentation of triglyceride synthesis in adipose tissue by transgenic overexpression the diacylglycerol aclytransferase-1 (Dgat1) gene causes obesity and/or alters insulin sensitivity. Male FVB mice expressing aP2-Dgat1 had threefold more Dgat1 mRNA and twofold greater DGAT activity levels tissue. After 30 weeks age, these hyperglycemia, hyperinsulinemia, glucose intolerance on a high-fat diet but were not obese than...
Visual impairment is associated with disability and poor quality of life. This study aimed to investigate the prevalence risk factors visual among suburban elderly in Eastern Taiwan. The cross-sectional research was conducted from April 2012 August 2012. ocular condition examination took place areas Hualien County. Medical records local infirmaries questionnaires were utilized collect demographic data systemic disease status. Logistic regression models used for simultaneous analysis...
Choline has critical roles during periods of rapid growth and development, such as infancy. In human milk, choline is mostly present in water-soluble forms (free choline, phosphocholine, glycerophosphocholine). It thought that milk concentration influenced by maternal intake, the richest food sources for are animal origin. Scarce information exists on from countries differing animal-source availability. this secondary analysis samples previous trials, concentrations were quantified liquid...
Mucopolysaccharidosis II (MPS II) is a rare lysosomal storage disease characterized by deficient activity of iduronate-2-sulfatase (I2S), leading to pathological accumulation glycosaminoglycans (GAGs) in tissues. We used knockout (Ids KO) mice investigate if liver-directed recombinant adeno-associated virus vectors (rAAV8-LSP-hIDSco) encoding human I2S (hI2S) could cross-correct deficiency Ids KO mouse tissues, and we then assessed the translation data non-human primates (NHPs). Treated...
Abstract: Epidemic viral conjunctivitis is a highly contagious disease that encountered year-round. The causative agents are mainly adenoviruses and enteroviruses. It occurs most commonly upon infection with subgroup D of types 8, 19, or 37. For common corneal involvement human adenovirus type 8 epidemic keratoconjunctivitis, full-layer epithelial detachment rarely seen. Herein, we report three cases keratoconjunctivitis during an outbreak which manifested as large within few days. lesions...