A5085734157- GaN-based semiconductor devices and materials
- Aortic aneurysm repair treatments
- Semiconductor materials and devices
- Aortic Disease and Treatment Approaches
- Venous Thromboembolism Diagnosis and Management
- Semiconductor Quantum Structures and Devices
- Infectious Aortic and Vascular Conditions
- Ga2O3 and related materials
- Peripheral Artery Disease Management
- Silicon Carbide Semiconductor Technologies
- Angiogenesis and VEGF in Cancer
- Renal cell carcinoma treatment
- Cerebrovascular and Carotid Artery Diseases
- Apelin-related biomedical research
- Abdominal vascular conditions and treatments
- Semiconductor materials and interfaces
- Cardiovascular Disease and Adiposity
- Radio Frequency Integrated Circuit Design
- State Capitalism and Financial Governance
- Advancements in Semiconductor Devices and Circuit Design
- Evaluation Methods in Various Fields
- Advanced Sensor and Control Systems
- Advanced Glycation End Products research
- Cardiac, Anesthesia and Surgical Outcomes
- Macrophage Migration Inhibitory Factor
Tianjin Medical University
2011-2025
Second Hospital of Tianjin Medical University
2011-2025
Institute of Microelectronics
2012-2024
Stanford University
2019-2024
Chinese Academy of Sciences
2012-2024
University of Chinese Academy of Sciences
2018-2022
Shaanxi University of Chinese Medicine
2021
Ningbo Transportation Planning and Design Institute (China)
2012
Tongji University
2010-2011
The physical mechanism of low-thermal-budget Au-free ohmic contacts to AlGaN/GaN heterostructures is systematically investigated with current-voltage, high-resolution transmission electron microscopy, and temperature-dependent contact resistivity characterizations. With a low annealing temperature 600 °C, pre-ohmic recess etching the AlGaN barrier down several nanometers demonstrated be an effective method reduce resistance between Ti/Al/Ti/W metals heterostructures. However, further over...
Low damage atomic layer etching (ALE) gate recess is developed for fabrication of millimeter-wave AlGaN/GaN high-electron-mobility transistors (HEMTs). Plasma ion induced bombardments to the AlGaN barrier effectively suppressed by ALE recess, contributing a well-controlled recessed surface morphology. The lattice heterostructure also reflected significantly reduced leakage as well an invisible threshold voltage shift associated with traps. With 0.15-μm T-gate technology, high power-gain...
In this study, we retrospectively analyzed the incidence of and risk factors for in-hospital venous thromboembolism (VTE) in patients with bladder cancer explored measures to reduce and/or prevent VTE mortality. The clinical data 5744 who were admitted Second Hospital Tianjin Medical University during a 5-year period summarized then determine aim identifying preventive measures. Univariate analysis revealed significant differences between group non-VTE terms age, sex, Caprini score, surgical...
Dapagliflozin, a sodium glucose transporter protein-2 (SGLT-2) inhibitor, reduces the risk for cardiovascular diseases. However, influence of dapagliflozin on nondissecting abdominal aortic aneurysms (AAAs) remains unclear. AAAs were created in male C57BL/6 mice via intra-aortic porcine pancreatic elastase (PPE) infusion. Mice daily treated with (1 or 5 mg/kg body weight) an equal volume vehicle through oral gavage beginning one day prior to PPE infusion 14 days. To investigate its...
An obvious increase in the gate leakage current has been commonly observed GaN HEMTs, after Plasma-enhanced chemical vapor deposition (PECVD) SiN passivation to obviously increase. This paper presents an Al/SiN stack layer structure. The high HEMTs caused by PECVD is distinctly reduced 2 3 orders of magnitude introducing a thin Al layer. It mainly attributed blocking and minimizing damage for (Al)GaN surface build-up luminance process then reducing trap density. TEM mapping SRIM software...
In this letter, a high-temperature (HT) gate recess technique is implemented into the fabrication of high-performance millimeter-wave AlGaN/GaN highelectron-mobility transistors (HEMTs). By virtue low damage feature HT recess, high extrinsic transconductance 422 mS/mm, three-terminal breakdown voltage 134 V with source-drain separation 2.4 μm, and remarkable Schottky leakage current 1.6 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Rationale: Modulation of vascular smooth muscle cell (VSMC) phenotype plays a fundamental role in development and diseases. Although extensive studies uncovered the roles transcriptional regulation VSMC-specific gene expression, how posttranscriptional contributes to VSMC fate decisions remains be determined. Objective: To establish THO complex-dependent expression as novel regulatory basis controlling phenotypes. Methods Results: Immunohistochemical staining against THOC2 THOC5, 2...
Background Although diabetes attenuates abdominal aortic aneurysms (AAAs), the mechanisms by which suppresses AAAs remain incompletely understood. Accumulation of advanced glycation end- (AGEs) reduces extracellular matrix (ECM) degradation in diabetes. Because ECM is critical for AAA pathogenesis, we investigated whether AGEs mediate experimental suppression blocking AGE formation or disrupting AGE-ECM cross-linking using small molecule inhibitors. Methods and Results Male C57BL/6J mice...
Silicon nitride (SiNx) film grown by low-pressure chemical vapor deposition (LPCVD) is utilized as a gate dielectric for AlGaN/GaN metal-insulator-semiconductor high-electron-mobility transistors (MIS-HEMTs). Trap distribution at the gate-dielectric/III-nitrides interface characterized temperature-dependent ac-capacitance technique. The extracted state density D it decreases from 2.92 × 1013 to 1.59 1012 cm−2 eV−1 energy level depth (E C-E T) increases 0.29 0.50 eV, and then levels off E T =...
A drain-controlled current-mode deep level transient spectroscopy (I-DLTS), was developed for investigation of Semi-ON-state current collapse in AlGaN/GaN high electron mobility transistors (HEMTs). By inserting a graded AlGaN back-barrier between the GaN channel and buffer layer, hot-electron effect induced charging traps is effectively blocked, which contributes to remarkable suppressed HEMTs under stress. broad-distributed trap <inline-formula...
Metformin treatment attenuates experimental abdominal aortic aneurysm (AAA) formation, as well reduces clinical AAA diameter enlargement in patients with diabetes. The mechanisms of metformin-mediated suppression, and its efficacy suppressing established aneurysms, remain uncertain.Experimental AAAs were created male C57BL/6J mice via intra-aortic infusion porcine pancreatic elastase. alone (250 mg/kg), or metformin combined the 5' AMP-activated protein kinase (AMPK) antagonist Compound C...
Background C-reactive protein (CRP) levels are elevated in patients with abdominal aortic aneurysms (AAA). However, it has not been investigated whether CRP contributes to AAA pathogenesis. Methods deficient and wild type (WT) male mice were subjected induction via transient intra-aortic infusion of porcine pancreatic elastase. AAAs monitored by situ measurements maximal infrarenal external diameters immediately prior 14 days following elastase infusion. Key pathologies assessed...
Plasma enhanced atomic layer deposition (PEALD) SiN gate dielectric is performed on AlGaN/GaN metal-insulator-semiconductor high-electron-mobility transistor (MIS-HEMT). The fabricated MIS-HEMTs with 5 nm exhibits a tiny threshold voltage hysteresis (~ 0.04 V), sufficiently decreased leakage current of ~10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">−9</sup> A/mm at <inline-formula xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math...
Background Interleukin-19 is an immunosuppressive cytokine produced by immune and nonimmune cells, but its role in abdominal aortic aneurysm (AAA) pathogenesis not known. This study aimed to investigate interleukin-19 expression in, influences on, the formation progression of experimental AAAs. Methods Results Human specimens were obtained at repair surgery or from transplant donors. Experimental AAAs created 10- 12-week-old male mice via intra-aortic elastase infusion. Influence potential...
Porcine pancreatic elastase (PPE) is successfully used to induce abdominal aortic aneurysm (AAA) in mice. However, differences between mouse strains susceptibility PPE induction have been reported. Kunming one of the most frequently China but whether it suitable for AAA by application remains unclear.
Abstract Enhancement-mode (E-mode) GaN-on-Si radio-frequency (RF) high-electron-mobility transistors (HEMTs) were fabricated on an ultrathin-barrier (UTB) AlGaN (<6 nm)/GaN heterostructure featuring a naturally depleted 2-D electron gas (2DEG) channel. The E-mode HEMTs exhibit relatively high threshold voltage ( V TH ) of +1.1 with good uniformity. A maximum current/power gain cut-off frequency f T / MAX 31.3/99.6 GHz power added efficiency (PAE) 52.47% and output density P out 1.0 W/mm...
Purpose: To analyze the clinical efficacy of superselective renal artery embolization and retroperitoneal laparoscopic partial nephrectomy for treatment ruptured hemorrhagic angiomyolipoma to provide a reference selection methods angiomyolipoma. Methods: A retrospective analysis was conducted on data 24 patients who were diagnosed with at Second Hospital Tianjin Medical University between January 2019 December 2021. Among them, 10 treated arterial (SAE), 14 part (RLPN). The differences two...
Aim Compared with the C57BL/6N substrain, C57BL/6J substrain is more susceptible to angiotensin II (Ang II)-induced development of dissected abdominal aortic aneurysms (AAAs). The aim this study was elucidate whether widely used mouse as porcine pancreatic elastase (PPE) infusion-induced experimental nondissected AAA development. Methods Experimental AAAs were induced in and mice via transient luminal infusion PPE. On Day 0 (baseline) 14 after PPE infusion, diameter directly measured. Aortic...
Background: Cysteinyl leukotrienes (LTs) and their receptors are involved in the pathogenesis of abdominal aortic aneurysms (AAAs). However, whether CysLT1 receptor antagonists such as montelukast can influence experimental nondissecting AAA remains unclear. Methods: Nondissecting AAAs were induced C57BL/6J mice by transient luminal infusion porcine pancreatic elastase (PPE). All animals administrated (1 or 10 mg/kg, daily) vehicle gavage beginning 1 day before PPE for 14 days. On 0...
Vascular remodeling in response to hemodynamic alterations is a physiological process that requires coordinated signaling between endothelial, inflammatory and vascular smooth muscle cells (VSMCs). Extensive experimental clinical studies have indicated the critical role of Ras homolog gene family, member A/Rho‑associated kinase (ROCK) pathway pathogenesis cardiovascular disease, where ROCK activation has been demonstrated promote inflammation through inducing expression proinflammatory...