A5044433321- Apelin-related biomedical research
- biodegradable polymer synthesis and properties
- Cancer Immunotherapy and Biomarkers
- Liver Disease Diagnosis and Treatment
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cardiovascular Disease and Adiposity
- Autophagy in Disease and Therapy
- Bone Tissue Engineering Materials
- Traditional Chinese Medicine Analysis
- Microplastics and Plastic Pollution
- Pharmacological Effects of Natural Compounds
- Lung Cancer Treatments and Mutations
- MicroRNA in disease regulation
- Metabolism, Diabetes, and Cancer
- Silk-based biomaterials and applications
- Adipose Tissue and Metabolism
- Immune cells in cancer
- Aortic aneurysm repair treatments
- Esophageal Cancer Research and Treatment
- Diet, Metabolism, and Disease
- Electrospun Nanofibers in Biomedical Applications
- Andrographolide Research and Applications
- Antioxidant Activity and Oxidative Stress
- Lung Cancer Research Studies
- Nanoplatforms for cancer theranostics
Hangzhou Cancer Hospital
2020-2025
West Virginia University
2025
Southwest Jiaotong University
2025
Zhejiang Cancer Hospital
2024
Hubei University of Medicine
2020-2024
Women's Hospital, School of Medicine, Zhejiang University
2024
Nanjing University of Chinese Medicine
2024
Jiangsu Province Hospital
2024
Xi'an Jiaotong University
2018-2023
Xuzhou Medical College
2023
Schwann cells injury induced by high glucose (HG) contributes to the development of diabetic peripheral neuropathy (DPN). Honokiol has been reported regulate metabolism, however, its effect on DPN and precise molecular mechanisms remain unclear. This study aimed investigate role AMPK/SIRT1/PGC-1α axis in protective effects honokiol DPN. The biochemical assay JC-1 staining results demonstrated that reduced HG-induced oxidative stress ferroptosis as well mitochondrial dysfunction cells....
The vascular aging process accelerated by type 2 diabetes mellitus (T2DM) is responsible for the elevated risk of associated cardiovascular diseases (CVDs). Metabolic disorder-induced immune senescence has been implicated in multi-organ/tissue damage. Herein, we sought to determine role immunosenescence diabetic and investigate underlying mechanisms.
Recent studies mentioned that Andrographolide (Andro), the main bioactive component of traditional Chinese medicine Andrographis paniculata, may be a potential natural product for treating Alzheimer's disease, but underlining mechanism remains to discovered. In this study, we investigated whether Andro regulates nuclear factor E2-related 2 (Nrf2)/Sequestosome 1 (p62) signaling pathway and activates autophagy protect neuronal PC12 cells from toxicity β-amyloid (Aβ) peptide. Our results...
Ethoxysanguinarine (Eth) is a benzophenanthridine alkaloid extracted from Macleaya cordata (Willd) R. Br. It possesses antibacterial and antiviral activities offers therapeutic benefits for the treatment of respiratory syndrome virus-induced cytopathic effects. However, effect Eth on human tumors its pharmacological effects remain to be elucidated, together with cellular target. Here, we examined breast cancer (BC) cells. We found that at low doses, strongly inhibited viability BC cell lines...
Thrombosis is a key pathological event in cardiovascular diseases, and also the most important targeting process for their clinical management. New drug development thrombosis treatment still great demand. According to traditional Chinese medicine (TCM) theory, belongs syndrome of blood stasis. Salvia miltiorrhiza Bunge Ligusticum striatum DC . are two common TCM herbs with long-term documented function promoting circulation inhibiting thrombosis, especially when used together. Guanxinning...
Pulmonary enteric adenocarcinoma (PEAC, also known as Enteric-type of the lung, lung - ETAC) is a rare subtype non-small cell cancer (NSCLC) that has same morphological and immunohistochemical characteristics colorectal requires gastroenteroscopy to rule out lesions origin. As solid tumor in cancer, PEAC unique clinical outcome, imaging, pathological molecular characteristics, poor prognosis. However, therapeutic biomarkers are unclear, its treatment remains challenging. In this case, we...
Abstract Background Cervical squamous cell carcinoma (CSCC) threatens the body health of women worldwide. This study aimed to foster a new concept prognostic indicator named death index (CDI). Methods RNA‐seq and scRNA‐seq datasets were downloaded from GEO TCGA database as training validation cohorts. Programmed (PCD)‐related gene signatures obtained published research. The construction model was performed based on CDI value. Patients with CSCC divided into high‐ low‐CDI groups. We explored...
The combination of radiation with immune checkpoint inhibitors (ICIs) has been demonstrated to display synergistic effects in solid cancers. Nevertheless, the anti-tumor effect combining programmed cell death 1 ligand (PD-L1) inhibitor esophageal squamous carcinoma (ESCC) remained unclear. Therefore, objectives our study were evaluate PD-L1 combined radiotherapy a mouse model ESCC and depict landscape within tumor microenvironment (TME). Murine cells (mEC25) injected subcutaneously into...
Introduction Osteoarthritis (OA) remains a significant clinical challenge, necessitating improved strategies for cartilage repair. Stem cells and scaffolds have crucial roles in tissue repair regeneration. In this study, we comprehensively investigated the proliferation differentiation potential of infrapatellar fat pad stem (IFPSCs), synovium-derived (SDSCs), bone marrow (BMSCs) from unpretreated knee joints young rabbits, after decellularized extracellular matrix (dECM) deposition by cell...
Abstract Background: Immune checkpoint inhibitors (ICIs) targeting programmed cell death protein 1 (PD-1) or ligand 1(PD-L1) respond well to deficient-microsatellite(dMMR) colorectal cancer and poorly proficient-microsatellite (pMMR) CRC. Anti-vascular therapy is the standard backline treatment regimen for advanced metastatic also potentiates immunotherapeutic efficacy of CRC by promoting immune infiltration remodeling tumor microenvironment (TIME). However, it not clear whether combining...
Silibinin is a flavonolignan from milk thistle with many pharmacological activities including lipid-lowering and antioxidant. Caspase 8 Fas-associated protein death domain-like apoptosis regulator (CFLAR) an important target gene in regulating non-alcoholic steatohepatitis (NASH). At present, the effect of silibinin on CFLAR-JNK pathway related to NASH was unknown. Here its downstream genes involved lipid metabolism, glucose uptake, oxidative stress inflammatory response were studied oleic...
ABSTRACT Radiation resistance is a crucial factor influencing therapeutic outcomes in colorectal cancer (CRC). Baicalein (BE), primarily derived from Scutellaria baicalensis , has demonstrated anti‐CRC properties. However, the impact of BE on radiosensitivity CRC remains unclear. This study aimed to evaluate radiosensitization effects and elucidate its mechanism radiotherapy. We established an vitro radioresistant cell model (CT26‐R) using parental cells (CT26) subjected ionizing radiation...
The proliferation and migration of vascular smooth muscle cells (VSMCs) are key steps in the progression atherosclerosis. aim present study was to investigate potential roles salusin-α functions VSMCs during development atherosclerosis.In vivo, effects on atherogenesis were examined rabbits fed a cholesterol diet. aortas en face stained with Sudan IV evaluate gross atherosclerotic lesion size. cellular components plaques analyzed by immunohistochemical methods. In vitro, Cell Counting Kit-8...