A5053269101- Immune cells in cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Glioma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Nuclear Receptors and Signaling
- Adenosine and Purinergic Signaling
- Macrophage Migration Inhibitory Factor
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Chemokine receptors and signaling
- Advanced Photocatalysis Techniques
- Heavy Metal Exposure and Toxicity
- Pancreatic and Hepatic Oncology Research
- RNA Interference and Gene Delivery
- Cancer-related gene regulation
- Gas Sensing Nanomaterials and Sensors
- Catalytic Processes in Materials Science
- Reproductive Biology and Fertility
- Esophageal Cancer Research and Treatment
- Adipose Tissue and Metabolism
- Epigenetics and DNA Methylation
- Wound Healing and Treatments
- Immune Cell Function and Interaction
Hangzhou Cancer Hospital
2016-2025
Northeast Institute of Geography and Agroecology
2021-2025
Chinese Academy of Sciences
2021-2025
Stomatology Hospital
2024-2025
Nanjing University
2018-2025
Hangzhou Normal University
2025
Nanjing Drum Tower Hospital
2020-2024
Huazhong University of Science and Technology
2013-2024
Tongji Hospital
2013-2024
Zhejiang Cancer Hospital
2024
Glioblastoma (GBM) constitutes the most lethal primary brain tumor for which immunotherapy has provided limited benefit. The unique immune landscape is reflected in a complex microenvironment (TIME) GBM. Here, single-cell sequencing of GBM TIME revealed that microglia were under severe oxidative stress, induced nuclear receptor subfamily 4 group A member 2 (NR4A2)-dependent transcriptional activity microglia. Heterozygous Nr4a2 (Nr4a2+/-) or CX3CR1+ myeloid cell-specific...
Abstract Five-year survival rate of esophageal squamous cell carcinoma (ESCC) patients treated with radiotherapy is <20%. Our study aimed to investigate whether cancer-associated fibroblasts (CAFs), one major component tumor microenvironment, were involved in radioresistance ESCC. By use human chemokine/cytokine array, chemokine CXCL1 was found be highly expressed CAFs compared that matched normal fibroblasts. Inhibition expression significantly reversed CAF-conferred vitro and vivo ....
Abstract STUDY QUESTION Do cumulative live birth rates (CLBRs) after one complete ART cycle differ between the three commonly used controlled ovarian stimulation (COS) protocols (GnRH antagonist, depot GnRHa agonist) and long GnRHa) in normal responders undergoing IVF/ICSI? SUMMARY ANSWER There were similar CLBRs GnRH protocols. WHAT IS KNOWN ALREADY is no consensus on which COS protocol most optimal women with response. The CLBR provides final success rate cycle, including fresh all...
Previous studies on the mechanisms underlying ESCC (esophageal squamous cell carcinoma) chemoresistance only focused tumor cells while microenvironment has been completely ignored. Our study aimed to clarify effect of CAFs (cancer-associated fibroblasts), one major component microenvironment, ESCC. By primary culture, two pairs and matched NFs (normal fibroblasts) were isolated from tissues patients normal esophageal epithelial tissues, respectively. The association was assessed in carcinoma...
Exposure to metals, including essential and nonessential elements, is widespread may be associated with altered semen quality. This study aimed examine the association between urinary metal concentrations quality in a Chinese population. We measured parameters (sperm concentration, count, motility, normal morphology, abnormal head) 13 metals [arsenic (As), cadmium (Cd), cobalt (Co), chromium (Cr), copper (Cu), iron (Fe), lead (Pb), manganese (Mn), molybdenum (Mo), mercury (Hg), nickel (Ni),...
Triple-negative breast cancer (TNBC) is a subtype of with aggressive behavior and poor prognosis. Current therapeutic options available for TNBC patients are primarily chemotherapy. With our evolving understanding this disease, novel targeted therapies, including poly ADP-ribose polymerase (PARP) inhibitors, antibody–drug conjugates, immune-checkpoint have been developed clinical use. Previous reports demonstrated the essential role estrogen receptor β (ERβ) in TNBC, but detailed molecular...
Background: Exposure to disinfection by-products (DBPs) has been demonstrated impair male reproductive health in animals, but human evidence is limited and inconsistent.Objective: We examined the association between exposure drinking-water DBPs semen quality a Chinese population.Methods: recruited 2,009 men seeking analysis from Reproductive Center of Tongji Hospital Wuhan, China, April 2011 May 2012. Each man provided sample urine sample. Semen samples were analyzed for sperm concentration,...
// Hongfang Zhang 1,* Honglei Luo 2,* , Zhaoyang Hu Jin Peng 2 Zhenzhen Jiang 1 Tao Song Bo Wu Jing Yue Rongjing Zhou 3 Ruifei Xie 1,4 Tian Chen and Shixiu Hangzhou Cancer Institution, Hospital, Hangzhou, China Department of Radiotherapy, Huai'an First People's Huai'an, Pathology, 4 Bio-Informatics, * These authors contributed equally to this work Correspondence: Wu, email: Keywords : ESCC, radioresistance, WISP1, prognostic significance, mechanisms Received October 21, 2014 Accepted January...
Abstract The efficacy of radiotherapy, one major treatment modality for esophageal squamous cell carcinoma (ESCC) is severely attenuated by radioresistance. Epithelial-to-mesenchymal transition (EMT) a cellular process that determines therapy response and tumor progression. However, whether EMT induced ionizing radiation involved in radioresistance has been less studied ESCC. Using multiple fractionated irradiation, the radioresistant cancer line KYSE-150R had established from its parental...
Targeting immune checkpoints, such as PD-1, represents a promising approach for cancer immunotherapy, achieving long-term disease remission rates in numerous types of cancer. T cell immunoglobulin and ITIM domain (TIGIT) is checkpoint receptor associated with the antitumor roles NK cells. Notably, blockade TIGIT has been revealed potential immunotherapy. However, therapeutic blocking myelodysplastic syndrome (MDS) remains unclear further research required to reveal their role.Fresh...