A5053047432- interferon and immune responses
- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Oral Health Pathology and Treatment
- RNA modifications and cancer
- Immune Response and Inflammation
- Cancer-related gene regulation
- ATP Synthase and ATPases Research
- Inflammasome and immune disorders
- RNA Interference and Gene Delivery
- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Barrier Structure and Function Studies
- Pancreatic and Hepatic Oncology Research
- Hepatitis B Virus Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Drug Transport and Resistance Mechanisms
- Ferroptosis and cancer prognosis
- Immune cells in cancer
Stomatology Hospital
2024-2025
Nanjing University
2024-2025
China Pharmaceutical University
2020-2021
Cyclic guanosine monophosphate (GMP)-AMP synthase (cGAS), upon sensing cytosolic DNA, catalyzes the production of cyclic monophosphate-adenosine (cGAMP), which activates STING-TBK1-IRF3 signaling. cGAS is also present in nucleus, but relevant nuclear function or mechanism remains largely unknown. Here, we report that indispensable for inducing cytokines and chemokines triggered by RNA/DNA viruses. Unexpectedly, DNA-binding/nucleotidyltransferase activity dispensable RNA-virus-induced genes...
ABSTRACT Background The molecular profile of cells within the tumor invasive zone, where interact with surrounding non‐tumor cells, plays a crucial role in defining malignant characteristics, such as pattern invasion (POI). Therefore, evaluating diagnostic value proliferation index molecule, Ki‐67, both and adjacent at zone different POIs, holds significant clinical importance for oral squamous cell carcinoma (OSCC). Methods This retrospective study included 133 primary OSCC samples, spatial...
Cyclic GMP-AMP synthase (cGAS), serving as a primary sensor of intracellular DNA, is essential to initiate anti-microbial innate immunity. Inappropriate activation cGAS by self-DNA promotes severe autoinflammatory diseases such Aicardi–Goutières syndrome (AGS); thus, inhibition may provide therapeutic benefit in anti-autoimmunity. Here we report that perillaldehyde (PAH), natural monoterpenoid compound derived from Perilla frutescens , suppresses cytosolic-DNA-induced immune responses...
Abstract Cyclic GMP-AMP synthase (cGAS), a key sensor of intracellular DNA, is essential for eliciting innate immunity against infection, whereas aberrant activation cGAS by endogenous DNA promotes severe autoimmune diseases. However, it largely unknown how expression regulated during pathogen infection and autoimmunity. Here, we report that herpes simplex virus type 1 (HSV-1) two microRNAs (miR-23a miR-23b) whose levels significantly decrease due to their interaction with the lncRNA...
Abstract Background Apoptosis can fuel oncogenesis by the education of surrounding stromal cells. However, function cancer‐associated fibroblasts (CAFs), which interacted with apoptotic cancer cells, in oral squamous cell carcinoma (OSCC) progression is still unknown. Objectives This study aimed to explore prognostic value apoptosis and biological effects CAFs, on OSCC. Methods A total 166 samples from OSCC patients were stained via TUNEL reaction evaluate correlation between clinical...
Abstract Small molecule inhibitors of apoptosis proteins (IAPs) antagonists, known as Smac mimetics (SMs), activate non-canonical NF-κB and sensitize cancer cells to TNF-induced cell death. SMs are currently in phase III clinical trials for head neck squamous carcinoma (HNSCC) after promising II trials. To explore the utility oral (OSCC), we tested nine human OSCC lines correlated SM sensitivity with both IAP mutation expression levels. cIAP1 protein was shown be higher a predictor poor...