A5030907892- Colorectal Cancer Screening and Detection
- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Diverticular Disease and Complications
- Genetic factors in colorectal cancer
- Colorectal and Anal Carcinomas
- Inflammatory Bowel Disease
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Anorectal Disease Treatments and Outcomes
- Nutritional Studies and Diet
- Radiomics and Machine Learning in Medical Imaging
- Cytokine Signaling Pathways and Interactions
- Immune Cell Function and Interaction
- Pancreatic and Hepatic Oncology Research
- Appendicitis Diagnosis and Management
- Air Quality and Health Impacts
- IL-33, ST2, and ILC Pathways
- Gut microbiota and health
- Nutrition and Health in Aging
- Global Cancer Incidence and Screening
- Epigenetics and DNA Methylation
- Climate Change and Health Impacts
- Chemokine receptors and signaling
Sun Yat-sen University
2016-2025
Sixth Affiliated Hospital of Sun Yat-sen University
2016-2025
Shanxi Datong University
2017-2024
Harvard University
2018-2023
Massachusetts General Hospital
2018-2023
The First Affiliated Hospital, Sun Yat-sen University
2019
Huazhong University of Science and Technology
2014-2017
Ministry of Ecology and Environment
2014-2015
National Natural Science Foundation of China
2015
Fuzhou University
2010
Colorectal cancer (CRC) incidence and mortality among individuals younger than 50 years (early-onset CRC) are increasing. The reasons for such increases largely unknown, although the increasing prevalence of obesity may be partially responsible.To investigate prospectively association between weight gain since early adulthood with risk early-onset CRC.The Nurses' Health Study II is a prospective, ongoing cohort study US female nurses aged 25 to 42 at enrollment (1989). A total 85 256 women...
Abstract Background and Objectives To investigate the expression dynamics of CD73 its prognostic significance in human colorectal cancer (CRC). Methods were detected by Western blotting. Immunohistochemistry was used to examine CRC tissues from two independent cohorts tissue microarrays. The optimal cutpoint assessed X‐tile program. Results blotting analysis demonstrated that significantly higher than normal tissues. According program, for high determined when index more 5.9. High observed...
BackgroundEpidemiological studies have suggested an association between external estimates of exposure to metals in air particles and altered heart rate variability (HRV). However, on the internal assessments HRV are limited.ObjectivesThe purpose this study was examine potential urinary among residents urban community Wuhan, China.MethodsWe performed a cross-sectional analysis 23 5-min indices (SDNN, standard deviation normal-to-normal intervals; r-MSSD, root mean square successive...
Particulate air pollution has been recognized to be associated with a wide range of adverse health effects, including increased mortality, morbidity, exacerbation respiratory conditions. However, earlier physiological or pathological changes long-term bodies' reaction pollutants have not studied in depth China. The Wuhan-Zhuhai (WHZH) cohort study is designed investigate the association between exposure and reactions on cardiovascular system.The community-based prospective that includes 4812...
Acute coronary syndrome (ACS) is a leading cause of death worldwide. Immune functions play vital role in ACS development; however, whether epigenetic modulation contributes to the regulation blood immune cells this disease has not been investigated.We conducted an epigenome-wide analysis with circulating identify differentially methylated genes ACS.We examined genome-wide methylation whole 102 patients and 101 controls using HumanMethylation450 array, externally replicated significant...
Exposure to metals, including essential and nonessential elements, is widespread may be associated with altered semen quality. This study aimed examine the association between urinary metal concentrations quality in a Chinese population. We measured parameters (sperm concentration, count, motility, normal morphology, abnormal head) 13 metals [arsenic (As), cadmium (Cd), cobalt (Co), chromium (Cr), copper (Cu), iron (Fe), lead (Pb), manganese (Mn), molybdenum (Mo), mercury (Hg), nickel (Ni),...
Increasing interest has developed in the therapeutic potential of bone marrow-derived mesenchymal stem cells (MSCs) for treatment inflammatory bowel disease (IBD) and IBD-induced cancer. However, whether MSCs have ability to suppress or promote tumor development remains controversial. The stromal cell-derived factor 1 (SDF-1)/C-X-C chemokine receptor type 4 (CXCR4) axis is well known play a critical role homing MSCs. In this study, we aimed evaluate CXCR4-overexpressing on tumorigenesis IBD....
Screening for early‐stage disease is vital reducing colorectal cancer (CRC)‐related mortality. Methylation of circulating tumor DNA has been previously used various types screening. A novel cell‐free (cfDNA) methylation‐based model which can improve the early detection CRC warranted. For our study, we collected 313 tissue and 577 plasma samples from patients with CRC, advanced adenoma (AA), non‐AA healthy controls. After quality control, 187 (91 non‐malignant patients, 26 AA 70 CRC) 489...
Epidemiologic evidence relating fiber intake to colorectal cancer (CRC) remains inconclusive and data are limited on different food sources of heterogeneity by tumor subsite molecular profile. We prospectively followed for CRC incidence 90,869 women from the Nurses' Health Study (1980-2012) 47,924 men Professionals Follow-up (1986-2012), who completed a validated frequency questionnaire every 4 years. Cox proportional hazards regression was used examine associations with risk total, cereal,...
Coffee may protect against multiple chronic diseases, particularly type 2 diabetes, but the mechanisms remain unclear.Leveraging dietary and metabolomic data in two large cohorts of women (the Nurses' Health Study [NHS] NHSII), we identified validated plasma metabolites associated with coffee intake 1,595 women. We then evaluated prospective association coffee-related diabetes risk added predictivity these for nested case-control studies (n = 457 case 1,371 control subjects).Of 461...
Growing evidence indicates the adverse effect of ultra-processed food (UPF) consumption. However, it remains unknown whether UPF consumption influences risk colorectal cancer (CRC) precursors, namely conventional adenomas and serrated lesions.
Metabolic reprogramming is a hallmark of cancer. Rewiring amino acid metabolic processes provides the basis for deprivation therapies. In this study, we found that arginine biosynthesis limited in colorectal cancer (CRC) due to deficiency ornithine transcarbamylase (OTC). Accordingly, CRC cells met demand by increasing external uptake. The addiction environmental resulted susceptibility deprivation, which dramatically decreased proliferation and promoted these enter reversible quiescence...