A5071063803- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Liver Disease and Transplantation
- Gastrointestinal disorders and treatments
- Diverticular Disease and Complications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Lipids, and Metabolism
- Mycobacterium research and diagnosis
- Hepatitis B Virus Studies
- Microscopic Colitis
- Genetic factors in colorectal cancer
- Hepatitis C virus research
- Gastric Cancer Management and Outcomes
- Colorectal and Anal Carcinomas
- Inflammatory Biomarkers in Disease Prognosis
- Inflammatory Bowel Disease
- Renal cell carcinoma treatment
- Appendicitis Diagnosis and Management
- Pancreatic and Hepatic Oncology Research
- Cancer Mechanisms and Therapy
- Colorectal Cancer Surgical Treatments
- Celiac Disease Research and Management
- Eosinophilic Esophagitis
- Pelvic floor disorders treatments
The University of Texas Southwestern Medical Center
2018-2025
National Yang Ming Chiao Tung University
2014-2022
Massachusetts General Hospital
2017-2021
Harvard University
2017-2021
Southwestern Medical Center
2019-2021
Parkland Health & Hospital System
2021
Taipei Veterans General Hospital
2014-2020
University of Taipei
2020
National Taipei University
2014-2020
Institute of American Indian Arts
2020
Colorectal cancer (CRC) incidence and mortality among individuals younger than 50 years (early-onset CRC) are increasing. The reasons for such increases largely unknown, although the increasing prevalence of obesity may be partially responsible.To investigate prospectively association between weight gain since early adulthood with risk early-onset CRC.The Nurses' Health Study II is a prospective, ongoing cohort study US female nurses aged 25 to 42 at enrollment (1989). A total 85 256 women...
To evaluate the efficacy of surgical resection (SR) and radiofrequency ablation (RFA) for single hepatocellular carcinoma (HCC) 2 cm or less.The optimal management Barcelona Clínic Liver Cancer (BCLC) very early-stage HCC is undetermined.Between 2002 2013, a total 237 (SR, 109; RFA, 128) patients with BCLC were enrolled. Their overall survival (OS) recurrence-free (RFS) compared. Propensity score matching analysis identified 79 matched pairs to compare outcomes.At baseline, SR younger had...
The severity of liver dysfunction in hepatocellular carcinoma (HCC) is often estimated with Child-Turcotte-Pugh (CTP) classification or model for end-stage disease (MELD) score. We aim to investigate the performance albumin-bilirubin (ALBI) and platelet-albumin-bilirubin (PALBI) grade, which are recently reported be simple objective measurements reserve HCC.Between 2002 2014, consecutive 3182 HCC patients were enrolled follow up their survival. area under receiver-operator-characteristic...
Colorectal cancer (CRC) diagnosed before age 50 years, or young-onset CRC, is increasing globally with undefined etiology. A sedentary lifestyle an emerging risk factor for CRC after but its role in unknown.We prospectively evaluated behaviors, primarily time watching television (TV), and of among 89 278 women the Nurses' Health Study II ages 25-42 years at recruitment (1991-2011). We used Cox proportional hazards modelling to estimate relative risks (RR) 95% confidence intervals (CIs)....
<h3>Importance</h3> Hepatocellular carcinoma (HCC) surveillance is underused in clinical practice, which may be owing to patient and clinician barriers. <h3>Objective</h3> To characterize HCC barriers associations with outcomes a multicenter cohort of patients cirrhosis. <h3>Design, Setting, Participants</h3> This retrospective, study included 5 medical centers the United States. Patients cirrhosis newly diagnosed treated from 2014 2018 were included. Data analyzed June 2021 February 2022....
Diverticulitis is a common disease with high clinical burden. We evaluated the joint contribution of multiple lifestyle factors to risks incident diverticulitis. also estimated proportion diverticulitis preventable by modifications.We prospectively examined association between (red meat, dietary fiber intake, vigorous physical activity (activity metabolic equivalent ≥6), body mass index (BMI), and smoking) risk among participants in Health Professionals Follow-Up Study.We documented 907...
Although low fiber intake has been considered a risk factor for diverticulitis, prospective evidence is limited in women despite having disproportionate burden of disease, with little known about variation the protective effects according to food sources. We assessed associations intakes and major sources including fruits vegetables diverticulitis large cohort women.
Professional society guidelines recommend semiannual screening for hepatocellular carcinoma (HCC) in patients with cirrhosis; however, studies suggest underuse of clinical practice. Our study's aim was to characterize reasons HCC among cirrhosis. We conducted a retrospective cohort study cirrhosis diagnosed two large health systems from 2011 2019. classified receipt as consistent, inconsistent, or no the year before diagnosis. categorized potential failure at each following steps required...
Background and Aims The prognostic ability of α-fetoprotein (AFP) for patients with hepatocellular carcinoma (HCC) was examined by using different cutoff values. optimal AFP level is still unclear. Methods A total 2579 HCC were consecutively enrolled in Taiwan, where hepatitis B the major etiology chronic liver disease. Four frequently used levels, 20, 200, 400, 1000 ng/mL, investigated. One-to-one matched pairs between having higher lower than cutoffs selected propensity model. adjusted...
Background & Aims Controversies exist on staging and management of solitary large (>5 cm) hepatocellular carcinoma (HCC). This study aims to evaluate the impact tumor size Barcelona Clinic Liver Cancer (BCLC) treatment strategy. Methods BCLC stage A B patients were included re-classified as single 2–5 cm or up 3 tumors ≤3 (group A; n = 657), >5 SL; 224), multiple >3 B; 351). Alternatively, 240 229 with HCC regardless received surgical resection (SR) transarterial chemoembolization (TACE),...
Size and number are major determinants of tumor burden in hepatocellular carcinoma (HCC). Patients with HCC undergoing transarterial chemoembolization (TACE) have variable outcomes due to heterogeneity burden. Recently, score (TBS) was proposed evaluate the extent involvement. However, prognostic accuracy TBS has not been well evaluated HCC. This study aimed assess its role patients TACE.A total 935 treatment-naïve receiving TACE were retrospectively analyzed. Multivariate Cox proportional...
The prognosis of hepatocellular carcinoma (HCC) varies widely due to variable tumor extent and liver reserve. We aimed develop validate a new prognostic model based on burden score (TBS) albumin–bilirubin (ALBI) grade for HCC. prospectively identified 3794 HCC patients who were randomized into derivation validation groups. Survival predictors evaluated by multivariate Cox model. TBS–ALBI system allocated two points high TBS ALBI 3, one point each the presence ascites, serum α-fetoprotein ≥...
(1) Background: The severity of liver functional reserve plays an important role in the management hepatocellular carcinoma (HCC). Noninvasive models such as model for end-stage disease (MELD), albumin-bilirubin (ALBI) grade and easy (EZ)-ALBI grade, platelet-albumin-bilirubin (PALBI) platelet-albumin (PAL) are used to evaluate dysfunction. We aimed compare prognostic performance these four albumin-based against MELD HCC patients undergoing transarterial chemoembolization (TACE). (2)...
<b><i>Background:</i></b> The aim of current study was to (1) construct and validate a novel hepatocellular carcinoma (HCC)-specific inflammatory index; (2) compare the performances Integrated Liver Inflammatory Score (ILIS) existing 4 indices in HCC; (3) explore association between systemic/intratumoral markers. <b><i>Methods:</i></b> Two cohorts from Hong Kong (HK; <i>n</i> = 1,315) Newcastle (<i>n</i> 574) were...
Abstract INTRODUCTION Inflammatory bowel disease (IBD) increases the risk of colorectal cancer (CRC). This study aimed to assess burden CRC among IBD patients within a large urban safety-net health system and identify potential missed opportunities for prevention. METHODS We retrospectively reviewed electronic medical records ages 18 older treated at an from January 2010 February 2024. Patients were included if they: 1) had diagnoses both CRC, identified using ICD codes; 2) undergone least...
Various noninvasive liver reserve markers were proposed to indicate the severity of damage. However, role and feasibility these predict prognosis patients with hepatocellular carcinoma (HCC) are unknown. We aimed identify prognostic 8 currently used hepatic in HCC undergoing transarterial chemoembolization (TACE).Between 2002 2013, a total 881 TACE prospectively identified retrospectively analyzed. The baseline characteristics, tumor status collected. Homogeneity corrected Akaike information...