A5100703316- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Organ Transplantation Techniques and Outcomes
- Drug-Induced Hepatotoxicity and Protection
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Eicosanoids and Hypertension Pharmacology
- Nitric Oxide and Endothelin Effects
- Gastroesophageal reflux and treatments
- Hormonal Regulation and Hypertension
- Diet, Metabolism, and Disease
- Alcohol Consumption and Health Effects
- Electrolyte and hormonal disorders
- Renal function and acid-base balance
- Cancer, Lipids, and Metabolism
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Liver physiology and pathology
- Hepatitis Viruses Studies and Epidemiology
- Biochemical effects in animals
- Gastrointestinal Bleeding Diagnosis and Treatment
- Esophageal and GI Pathology
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
National Yang Ming Chiao Tung University
2016-2025
Taipei Veterans General Hospital
2016-2025
Confluence Life Sciences (United States)
2024
National Taiwan University Hospital
2023-2024
Novo Nordisk (Italy)
2023
Mackay Memorial Hospital
2023
Far Eastern Memorial Hospital
2023
Sanofi (France)
2023
Eli Lilly (United States)
2023
Boehringer Ingelheim (United States)
2023
Bacterial infection may adversely affect the hemostasis of patients with gastroesophageal variceal bleeding (GEVB). Antibiotic prophylaxis can prevent bacterial in such patients, but its role preventing rebleeding is unclear. Over a 25-month period, acute GEVB without evidence were randomized to receive prophylactic antibiotics (ofloxacin 200 mg i.v. q12h for 2 days followed by oral ofloxacin 5 days) or only when became evident (on-demand group). Endoscopic therapy was performed immediately...
Progression of gastric variceal hemorrhage (GVH) is poorer than esophageal bleeding. However, data on its optimal treatment are limited. We designed a prospective study to compare the efficacy endoscopic band ligation (GVL) and N-butyl-2-cyanoacrylate injection (GVO). Liver patients with cirrhosis or without concomitant hepatocellular carcinoma (HCC) presenting acute GVH were randomized into two groups. Forty-eight received GVL, another 49 GVO. Both treatments equally successful in...
Purpose The role of antiviral prophylaxis in preventing hepatitis B virus (HBV) reactivation before rituximab-based chemotherapy patients with lymphoma and resolved is unclear. Patients Methods Eighty CD20 + were randomly assigned to receive either prophylactic entecavir (ETV) 3 months after completing (ETV group, n = 41) or therapeutic ETV at the time HBV surface antigen (HBsAg) reverse seroconversion since (control 39). Results Fifty-eight (72.5%) positive for antibody, DNA was...
To determine the efficacy of endoscopic variceal sclerotherapy (EVS) and ligation (EVL) in management esophageal bleeding, 134 cirrhotic patients were randomized to receive either treatment. The clinical characteristics similar both groups. Active bleeding was controlled with (20 20) as efficiently (14 16). Elective consumed less time than (7.9 +/- 1.8 minutes vs. 11.5 2.7 minutes, P < .001), but there no difference between emergent (14.5 5.8 minutes) (14.9 4.1 minutes). Ligation reduced one...
Performance status is included in the Barcelona Clinic Liver Cancer (BCLC) system for hepatocellular carcinoma (HCC). Few studies specifically evaluated role of performance patients with HCC. This study investigated its distribution, determinants, and prognostic impact, aiming to improve BCLC system. A total 2,381 HCC were enrolled. was determined according Eastern Cooperative Oncology Group scale. The ability original three modified systems compared by Akaike information criterion (AIC)....
To evaluate the efficacy of surgical resection (SR) and radiofrequency ablation (RFA) for single hepatocellular carcinoma (HCC) 2 cm or less.The optimal management Barcelona Clínic Liver Cancer (BCLC) very early-stage HCC is undetermined.Between 2002 2013, a total 237 (SR, 109; RFA, 128) patients with BCLC were enrolled. Their overall survival (OS) recurrence-free (RFS) compared. Propensity score matching analysis identified 79 matched pairs to compare outcomes.At baseline, SR younger had...
The severity of liver dysfunction in hepatocellular carcinoma (HCC) is often estimated with Child-Turcotte-Pugh (CTP) classification or model for end-stage disease (MELD) score. We aim to investigate the performance albumin-bilirubin (ALBI) and platelet-albumin-bilirubin (PALBI) grade, which are recently reported be simple objective measurements reserve HCC.Between 2002 2014, consecutive 3182 HCC patients were enrolled follow up their survival. area under receiver-operator-characteristic...
Summary Background Non‐alcoholic fatty liver disease (NAFLD) and non‐alcoholic steatohepatitis (NASH) account for an increasing proportion of in the Asia‐Pacific region. Many areas region are experiencing epidemics metabolic syndrome among rapidly ageing populations. Aims To estimate using modelling growth NAFLD populations, including cases with significant fibrosis that most likely to experience advanced related mortality. Methods A progression model was used summarise project populations...
Purpose To construct a nomogram with the albumin-bilirubin (ALBI) grade to assess long-term outcomes of patients early-stage hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA). Materials and Methods This retrospective study was approved by institutional review board, informed consent waived. We studied 622 treatment-naïve HCC according Milan criteria who subsequently underwent RFA from 2002 2013. Baseline characteristics were collected identify risk factors for determination...
Hepatitis C virus (HCV) infection is a silent killer that leads to rapid progression of liver cirrhosis and hepatocellular carcinoma (HCC). High prevalence HCV has been reported in Taiwan, especially high-risk populations including people who inject drugs (PWID) patients requiring dialysis. Besides, certain merit special considerations due suboptimal outcome, potential drug-drug interaction, or possible side effect. Therefore, the second part this 2-part consensus, Taiwan Association for...
Abstract Background & Aims Transarterial chemoembolization (TACE) is a standard treatment for Barcelona Clinic Liver Cancer (BCLC) stage B hepatocellular carcinoma (HCC), but the outcome varied. This study aimed to develop model predict of TACE in HCC patients. Methods Consecutive 570 treatment‐naïve BCLC patients undergoing as initial from 2007 2016 were retrospectively enrolled. Factors associated with survival analysed. Patients 2011 constituted training cohort (n = 293), while 2012...