A5090991069- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease and Transplantation
- Cancer Mechanisms and Therapy
- Liver Diseases and Immunity
- Glycosylation and Glycoproteins Research
- Systemic Lupus Erythematosus Research
- Cardiovascular Disease and Adiposity
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Spondyloarthritis Studies and Treatments
- Galectins and Cancer Biology
- Securities Regulation and Market Practices
- Bacteriophages and microbial interactions
- Vibrio bacteria research studies
- Inflammatory Bowel Disease
- Pharmaceutical industry and healthcare
- Cardiovascular Health and Disease Prevention
- Corporate Identity and Reputation
- Renal Transplantation Outcomes and Treatments
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Lung Cancer Treatments and Mutations
National Cheng Kung University Hospital
2016-2025
National Cheng Kung University
2009-2020
Creative Commons
2016
Christie's
2016
Chronic hepatitis C (CHC) patients who failed antiviral therapy are at increased risk for hepatocellular carcinoma (HCC). This study assessed the potential role of metformin and statins, medications diabetes mellitus (DM) hyperlipidemia (HLP), in reducing HCC among these patients. We included CHC from T-COACH therapy. tracked onset 1.5 years post-therapy by linking to Taiwan's cancer registry data 2003 2019. accounted death liver transplantation as competing risks employed Gray's cumulative...
Summary Background Lipid‐lowering effect was observed during treatment with tenofovir disoproxil fumarate (TDF) for chronic hepatitis B (CHB). However, the metabolic features in patients switching from TDF to alafenamide (TAF) remain unclear. Aims To compare impacts of TAF or entecavir on body weight and CHB. Methods This a multi‐centre, prospective, observational study CHB who switched TAF. Baseline characteristics, lipid profile sugar were determined. received IRB approval each hospital....
The objectives of the study were to investigate distribution cphA-related genes (cphA) encoding a CphA metallo-β-lactamase (MBL) among 51 consecutive Aeromonas blood isolates and compare different phenotypic methods for detecting CphA. presence cphA was detected by PCR. Four methods, imipenem-EDTA combined disc test, MBL Etest, agar dilution test modified Hodge (MHT), used detect imipenem susceptibility production. results showed that 35 (69%) had cphA. All (100%) 16 aquariorum 12 veronii...
Objective Lipid homoeostasis is disturbed in patients with HCV infection. Direct-acting antiviral agent (DAA) treatment eradicates chronic viraemia, but the dynamics of lipid components remain elusive. This study investigates clinical manifestation and mechanistic relevance plasma triglyceride (TG), cholesterol (Chol), lipoproteins apolipoproteins (apos) after DAA treatment. Design Twenty-four genotype 1 (GT1) treated elbasvir/grazoprevir or ledipasvir/sofosbuvir for 12 weeks, followed-up...
Galectin-1 (Gal-1) is a secretory lectin with pro-tumor activities and associated strongly hepatocellular carcinoma (HCC) development. Although Gal-1 well-known soluble factor in the tumor microenvironment (TME), secretion mode of not clearly defined. On other hand, addition to cancer cells, widely expressed stromal including tumor-associated macrophages (TAMs). TAMs are significant component cells TME; however, their contributions producing TME still explored. Here we reveal that can...
The management of acute cholecystitis is still based on clinical expertise. This study aims to investigate whether the outcome can be related severity criteria Tokyo guidelines and additional comorbidities. A total 103 patients with were retrospectively enrolled their medical records reviewed. They all classified according therapeutic modality, including early cholecystectomy antibiotic treatment or without percutaneous cholecystostomy. impact presence comorbidities assessed by univariate...
Abstract Programmed cell death protein-1 (PD-1) inhibitors have shown promising results for treating advanced hepatocellular carcinoma (HCC). However, the clinical utility of such in HCC patients with vascular tumor thrombosis remains unclear. This study investigated PD-1 inhibitor efficacy macrovascular invasion a setting. Among 110 unresectable treated inhibitors, 34 metastases portal vein and inferior vena cava were retrospectively compared without thrombi. The response its effect on...
INTRODUCTION: Chronic hepatitis C virus (HCV) infection is associated with nonhepatocellular carcinoma malignancies. We aimed to evaluate whether achieving a sustained virological response (SVR, defined as HCV RNA seronegativity throughout posttreatment 24-week follow-up) could reduce the risk of non–hepatocellular malignancy in real-world nationwide Taiwanese Hepatitis Cohort (T-COACH). METHODS: A total 10,714 patients chronic who had received interferon-based therapy (8,186 SVR and 2,528...
Sofosbuvir (SOF) and daclatasvir (DCV) treatment achieves excellent efficacy safety in treating chronic hepatitis C (CHC) with various genotypes. Real world experience of SOF/DCV regimen to treat genotype 2 CHC was scanty Asia. This study aimed evaluate the effectiveness or without ribavirin patients real practice Taiwan. Patients treated 12-week SOF/DCV/ribavirin were enrolled prospectively. Effectiveness evaluated by sustained virological response (SVR) which defined as undetectable virus...
It is currently unknown how hepatitis C virus (HCV) eradication with pegylated interferon and ribavirin (PR) therapy affects the incidence of new-onset liver cirrhosis (LC) in patients without decompensated disease (DLD) or hepatocellular carcinoma (HCC) cirrhosis.Taiwanese chronic cohort (T-COACH) a nationwide HCV registry from 23 hospitals Taiwan recruited between 2003 2015. This study enrolled 10 693 (CHC), linked to National Health Insurance Research Database, receiving PR for at least 4...
Sorafenib is the standard treatment for patients with Barcelona Clinic Liver Cancer (BCLC) stage C hepatocellular carcinoma (HCC). However, outcome not satisfactory. We retrospectively analyzed whether adding transarterial embolization/chemoembolization (TA(C)E)-based locoregional therapy to sorafenib can further improve efficacy.We included 147 BCLC HCC Child-Turcotte-Pugh class A liver function and treated analysis. Through propensity score matching, we divided into combined group (n = 63;...
Background and aim The role of non-invasive methods to evaluate fibrosis severity chronic hepatitis C (CHC) subjects in community needs be explored. This study investigated FIB-4 transient elastography (TE) staging liver CHC community. Methods A total 905 who were positive for anti-HCV antibody from five districts Tainan City Taiwan invited participate surveillance activities CHC. TE measured each participant. Results 502 with detectable HCV RNA valid enrolled. distribution values differed...
Chronic hepatitis C (CHC) is strongly associated with risks of cardiovascular diseases. The impact direct acting antiviral (DAA) therapy on central blood pressure remains unclear. This investigation evaluates changes in following DAA therapy. One hundred and two DAA-treated patients were prospectively enrolled. Lipid profiles pulse wave analysis brachial artery by cuff sphygmomanometry including augmentation index (AIx), a parameter stiffness, evaluated. All the 102 achieved sustained...
The application of liver stiffness measurement (LSM) by transient elastography (TE) in general population remains to clarify. This cohort study aimed examine the usefulness TE and identify factors associated with significant fibrosis community-based population.We conducted a hepatitis screening program 2 remote villages Southern Taiwan. All residents participated voluntarily received questionnaire evaluation, blood tests, abdominal sonography, LSM TE. Residents any one following criteria...
Hepatitis B virus (HBV) quasispecies are crucial in the pathogenesis of chronic liver disease. Next-generation sequencing (NGS) is powerful for identifying viral quasispecies. To improve mapping quality and single nucleotide variant (SNV) calling accuracy NGS analysis HBV, we compared different references, including sample-specific reference sequence, same genotype sequences sequences, according to sample. Real Illumina HBV datasets from 86 patients, simulated 158 strains GenBank database,...
Lipoprotein lipase (LPL) has been identified as an anti-hepatitis C virus (HCV) host factor, but the cellular mechanism remains elusive. Here, we investigated of LPL involving in anti-HCV. The functional activation peroxisome proliferator-activated receptor (PPAR) α signal by transducing into hepatocytes was HCV-infected cells, primary human hepatocytes, and HCV-core transgenic mice. result showed that levels transcriptional transactivity nuclear translocation PPARα Huh7 cells were elevated...
AIMTo investigate the utility of hepatitis B surface antigen (HBsAg) kinetics in chronic patients during long-term entecavir treatment. METHODSThis retrospective study included treatment-naïve who received at least 2 years consecutive treatment.Patients were followed up three to six month intervals with liver biochemistry, virus DNA, and abdominal sonography.In e (HBeAg)-positive patients, HBeAg levels assessed every until results became negative.Serum
Germinal center kinase-like kinase (GLK) is a key controller of autoimmunity. In this study, we assessed the clinical relevance and tumorigenic effects GLK in hepatocellular carcinoma (HCC). Using immunohistochemistry, showed that proportion score increased both cancerous adjacent non-cancerous liver tissue from patients with HCC recurrence. A Kaplan-Meier analysis revealed wide distribution had higher rate recurrence than those very low or no expression. Multivariate Cox regression analyses...
Abstract Background and Aim Infection with hepatitis C virus (HCV) genotype (GT) 6 is uncommon in Taiwan, reports of ledipasvir/sofosbuvir (LDV/SOF) treatment for GT6 are few. This study evaluates the effectiveness safety LDV/SOF treating chronic (CHC) patients infection. Methods CHC that were infected treated 12 weeks at two hospitals enrolled. All followed an additional after completion treatment. Demographics, HCV viral load, lipid sugar profiles, adverse events recorded reviewed. Results...
Prophylaxis with nucleos(t)ide analogue (NA) is recommended to prevent hepatitis B virus (HBV) reactivation in surface antigen (HBsAg)-positive patients receiving rituximab-based B-cell depletion therapy. However, little known about the risk of clinical relapse after withdrawal NA.We retrospectively analyzed 77 noncirrhotic HBsAg carriers hematological cancer who received rituximab-containing chemotherapy. All them either prophylactic entecavir or tenofovir The and hepatic decompensation...