Bacterial infection may adversely affect the hemostasis of patients with gastroesophageal variceal bleeding (GEVB). Antibiotic prophylaxis can prevent bacterial in such patients, but its role preventing rebleeding is unclear. Over a 25-month period, acute GEVB without evidence were randomized to receive prophylactic antibiotics (ofloxacin 200 mg i.v. q12h for 2 days followed by oral ofloxacin 5 days) or only when became evident (on-demand group). Endoscopic therapy was performed immediately...

Progression of gastric variceal hemorrhage (GVH) is poorer than esophageal bleeding. However, data on its optimal treatment are limited. We designed a prospective study to compare the efficacy endoscopic band ligation (GVL) and N-butyl-2-cyanoacrylate injection (GVO). Liver patients with cirrhosis or without concomitant hepatocellular carcinoma (HCC) presenting acute GVH were randomized into two groups. Forty-eight received GVL, another 49 GVO. Both treatments equally successful in...

Background Immune checkpoint inhibitors (ICIs) are promising agents for unresectable hepatocellular carcinoma (uHCC), but lack effective biomarker to predict outcomes. The gut microbiome can modulate tumor response immunotherapy, its effect on HCC remains unclear. Methods From May 2018 February 2020, patients receiving ICI treatment uHCC were prospectively enrolled; their fecal samples collected before treatment. microbiota and metabolites analyzed from 20 with radiology-proven objective...

The severity of liver dysfunction in hepatocellular carcinoma (HCC) is often estimated with Child-Turcotte-Pugh (CTP) classification or model for end-stage disease (MELD) score. We aim to investigate the performance albumin-bilirubin (ALBI) and platelet-albumin-bilirubin (PALBI) grade, which are recently reported be simple objective measurements reserve HCC.Between 2002 2014, consecutive 3182 HCC patients were enrolled follow up their survival. area under receiver-operator-characteristic...

Statin use decreases the risk of decompensation and mortality in patients with cirrhosis due to hepatitis C virus (HCV). Whether this beneficial effect can be extended general population or other causes, such as B (HBV) infection alcohol, remains unknown. also hepatocellular carcinoma (HCC) chronic HBV HCV infection. It is unclear whether observed pre-existing cirrhosis. The goal study was determine statin on rates decompensation, mortality, HCC HBV-, HCV-, alcohol-related Patients were...

Immune checkpoint inhibitors (ICIs) with nivolumab and pembrolizumab are promising agents for advanced hepatocellular carcinoma (HCC) but lack of effective biomarkers. We aimed to investigate the potential predictors response factors associated overall survival (OS) ICI treatment in unresectable HCC patients. Ninety-five patients who received or were enrolled analyses. Radiologic evaluation was based on RECIST v1.1. Factors outcomes analyzed. Of 90 evaluable images, objective rate (ORR)...

Abstract Background Patients with type 2 diabetes (T2D) tend to have nonalcoholic fatty liver disease (NAFLD) poorer prognosis. We performed this research compare the risks of cardiovascular diseases, cirrhosis, liver-related mortality, and mortality between glucagon-like peptide-1 receptor agonist (GLP-1 RA) use no-use in patients T2D without viral hepatitis. Methods From January 1, 2008, December 31, 2018, we used propensity-score matching identify 31,183 pairs GLP-1 RA users nonusers from...

Objective Live biotherapeutic products (LBPs) are biological composed of living micro-organisms, developed to prevent, treat, or cure diseases. Examples include cultured strains Akkermansia muciniphila and Christensenella minuta , as well treatments using purified Firmicutes spores for recurrent Clostridioides difficile infections. There is a need guidelines over the increasing interest in developing LBPs. A panel microbiome experts from Asia-Pacific countries articulates their perspectives...

Objectives: Cirrhotic patients with upper gastrointestinal bleeding are prone to bacterial infection. The aim of this study was investigate the efficacy prophylactic intestinal decontamination oral ciprofloxacin for prevention infections in cirrhotic bleeding. Methods: A total 120 acute were enrolled. Sixty received 500 mg twice daily given orally or through nasogastric tube immediately after endoscopic examination; drug administration continued 7 days. remaining 60 patients, who placebo,...

We tested serum samples from 25 fulminant hepatitis and 7 subfulminant patients for A, B, C, D E viral markers nucleic acids by means of polymerase chain reaction to determine the role each virus on such catastrophic events in an area endemic B. Of these 32 patients, 14 (44%) were B carriers with superinfection (1 C infection), 3 others had coexisting infections, 6 reactivation underlying chronic 4 acute 2 1 E. Pathogenesis remaining two cases was unclear. Serum DNA detectable most without...

Immunotherapy with immune checkpoint inhibitor (ICI) is a promising treatment for unresectable hepatocellular carcinoma (HCC). However, whether ICIs would have the risk of hepatitis B virus (HBV) reactivation and necessary nucleos(t)ide analogs (NUCs) prophylaxis are still unclear. We aimed to investigate role NUCs in HBV-infected patients who underwent treatment.The study was retrospective prospective design review follow-up consecutive 62 chronic or resolved HBV infection had received HCC....

Abstract Background Lenvatinib combined with pembrolizumab showed a promising result in an early phase study for hepatocellular carcinoma (HCC). The efficacy and safety of lenvatinib plus patients unresectable HCC (uHCC) beyond the first-line setting were unclear. Methods Seventy-one consecutive who received uHCC prospectively enrolled. Effect combinations on Albumin-Bilirubin (ALBI) score factors associated progression-free survival (PFS) overall (OS) analyzed. Results Of 71 cases, 58...

Background/Aims: The performance of machine learning (ML) in predicting the outcomes patients with hepatocellular carcinoma (HCC) remains uncertain. We aimed to develop risk scores using conventional methods and ML categorize early-stage HCC into distinct prognostic groups.Methods: study retrospectively enrolled 1,411 consecutive treatment-naïve Barcelona Clinic Liver Cancer (BCLC) stage 0 A from 2012 2021. were randomly divided a training cohort (n=988) validation (n=423). Two (CATS-IF...

Background: Liver cirrhosis with portal hypertension is associated hyperdynamic circulation characterized by generalized vasodilatation and increased cardiac output regional blood flows. Patients liver present levels of interleukin-6 (IL-6), which may inhibit vascular smooth-muscle contraction. We investigated whether plasma IL-6 contribute to the pathogenesis observed in cirrhotic patients they are correlated tumor necrosis factor-α (TNF-α) endotoxin concentrations. Methods: In 58...

Abstract Background and Aims Diabetic patients reportedly have a higher incidence of peptic ulcer disease. The aim this study was to investigate if type II diabetic risk developing bleeding ( PUB ) identify possible factors in patients. Methods Using the N ational H ealth I nsurance R esearch D atabase T aiwan, records 5699 11 226 age‐ sex‐matched non‐diabetic 1:2 ratio were extracted for comparison from cohort dataset 1 000 randomly sampled subjects. Log‐rank test used analyze differences...

Size and number are major determinants of tumor burden in hepatocellular carcinoma (HCC). Patients with HCC undergoing transarterial chemoembolization (TACE) have variable outcomes due to heterogeneity burden. Recently, score (TBS) was proposed evaluate the extent involvement. However, prognostic accuracy TBS has not been well evaluated HCC. This study aimed assess its role patients TACE.A total 935 treatment-naïve receiving TACE were retrospectively analyzed. Multivariate Cox proportional...

The prognosis of hepatocellular carcinoma (HCC) varies widely due to variable tumor extent and liver reserve. We aimed develop validate a new prognostic model based on burden score (TBS) albumin–bilirubin (ALBI) grade for HCC. prospectively identified 3794 HCC patients who were randomized into derivation validation groups. Survival predictors evaluated by multivariate Cox model. TBS–ALBI system allocated two points high TBS ALBI 3, one point each the presence ascites, serum α-fetoprotein ≥...

Abstract Background and Aims Inflammatory bowel disease (IBD) is a chronic gastrointestinal inflammatory disorder with increasing global prevalence. The risk of IBD in patients schizophrenia remains unclear. We aim to investigate the new‐onset compared matched controls. Methods conducted retrospective, population‐based cohort study utilising patient data from Taiwan National Health Insurance Research Database collected between January 1, 2001, December 31, 2011. Patients diagnosed by...

Advanced liver disease with massive damage may affect the metabolism of hypoglycemic agents and increase risk hypoglycemia. We conduct this research to compare severe hypoglycemia between patients type 2 diabetes, without compensated cirrhosis.From Taiwan's National Health Insurance Research Database, we identified persons diabetes cirrhosis (n = 18,209) 538,510) from January 1, 2000, December 31, 2010. Cox proportional hazards models were adopted assess risks all-cause mortality...

(1) Background: The severity of liver functional reserve plays an important role in the management hepatocellular carcinoma (HCC). Noninvasive models such as model for end-stage disease (MELD), albumin-bilirubin (ALBI) grade and easy (EZ)-ALBI grade, platelet-albumin-bilirubin (PALBI) platelet-albumin (PAL) are used to evaluate dysfunction. We aimed compare prognostic performance these four albumin-based against MELD HCC patients undergoing transarterial chemoembolization (TACE). (2)...

Introduction: Field factors play more important roles in predicting the outcomes of patients compared with tumor early-stage hepatocellular carcinoma (HCC). However, prognostic ability non-invasive serum marker scores for hepatic fibrosis and liver functional reserve on very HCC is still not yet determined. We aimed to investigate performance these prognoses HCC. Methods: A total 446 from 2012 2022 were retrospectively enrolled. Serum biomarkers determining overall survival (OS) analyzed by...

Oral antifungal agent-induced liver injury is a common safety concern that may lead to patients' hesitation in treating fungal infections such as onychomycosis. This study evaluated risk of drug-induced (DILI) caused by oral agents Taiwanese populations.A population-based was conducted analyzing who used from 2002 2008 the Taiwan National Health Insurance Database. A comparison control group randomly extracted remainder original cohort.Of 90,847 users, 52 patients had DILI. Twenty-eight DILI...

Selective serotonin receptor inhibitor (SSRI) and serotonin-noradrenaline reuptake (SNRI) users have been reported to an increased risk of upper gastrointestinal bleeding (UGIB), but their association with lower (LGIB) is less studied. This study aimed analyze the incidence UGIB LGIB among SSRI users, SNRI controls. Using National Health Insurance Research Database Taiwan, 9753 subjects who were taking inhibitors (8809 SSRIs, 944 SNRIs), 39,012 age, sex, enrollment time-matched controls...