A5066985721- Diabetes Management and Research
- Diabetes Treatment and Management
- Dialysis and Renal Disease Management
- Alcohol Consumption and Health Effects
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Liver Disease Diagnosis and Treatment
- Chronic Kidney Disease and Diabetes
- Gout, Hyperuricemia, Uric Acid
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Blood Pressure and Hypertension Studies
- Inflammatory mediators and NSAID effects
- Diet and metabolism studies
- Heart Failure Treatment and Management
- Renal function and acid-base balance
- Diabetes and associated disorders
- Drug-Induced Adverse Reactions
- Gastric Cancer Management and Outcomes
- Metabolism, Diabetes, and Cancer
- Pharmacology and Obesity Treatment
- Chronic Disease Management Strategies
- Antiplatelet Therapy and Cardiovascular Diseases
- Nutritional Studies and Diet
- Iron Metabolism and Disorders
- Agriculture Sustainability and Environmental Impact
- Erythropoietin and Anemia Treatment
National Health Research Institutes
2015-2024
Taipei Tzu Chi Hospital
2019-2024
Kaohsiung Medical University
2009-2023
Buddhist Tzu Chi Medical Foundation
2019-2023
Catholic University of America
2023
Dayeh University
2023
China Medical University
2015
Chinese Academy of Medical Sciences & Peking Union Medical College
2015
State Key Laboratory of Cardiovascular Disease
2015
Fu Wai Hospital
2015
No studies have reported the long-term outcomes of initiating sodium-glucose cotransporter-2 inhibitors (SGLT2is) in patients with estimated glomerular filtration rates less than 20 mL/min/1.73 m
The link between elevated serum uric acid (SUA) levels and cardiovascular disease (CVD)-related mortality in the elderly population remains inconclusive. Nutritional status influences both SUA CVD outcomes. Therefore, we investigated whether SUA-predicted effect-modifying roles of malnourishment older people. A longitudinal Taiwanese cohort including 127 771 adults 65 years participating Taipei City Elderly Health Examination Program from 2001 to 2010 were stratified by 1-mg/dL increment...
Diabetes mellitus (DM) and DM-related complications place a high socioeconomic burden on individuals society. Updating nationwide information periodically is thus pivotal to preventing DM improving its management in Taiwan. We used the National Health Insurance Research Database; disease diagnosis codes were assigned according International Classification of Diseases, 9th Revision, Clinical Modification. was defined as ≥3 outpatient visits or 1 hospitalization within year. excluded with...
Limited studies have examined the effects of nonsteroidal anti-inflammatory drug (NSAID) use on risk chronic kidney disease (CKD), especially in subjects with hypertension. Using National Health Insurance claims data Taiwan, we conducted a propensity score-matched cohort study to investigate relationship between NSAID and CKD A total 31976 were included this study: not taking any NSAIDs 2007 (n=10782); for 1 89 days (n=10605); ≥90 (n=10589). We performed multivariable proportional hazard...
Hyperuricemia is a well-known risk factor for chronic kidney disease (CKD). Little known about whether vegetarian diet associated with lower of CKD in patients hyperuricemia. From 5 September 2005, to 31 December 2016, we retrospectively included clinically stable hyperuricemia who received health check-ups at Taipei Tzu Chi Hospital. All participants completed dietary habits questionnaire determine they were omnivorous, lacto-ovo vegetarian, or vegan. was defined as an estimated glomerular...
Chronic kidney disease (CKD) and its complications are major global public health issues. Vegetarian diets associated with a more favorable profile of metabolic risk factors lower blood pressure, but the protective effect in CKD is still unknown. We aim to assess association between vegetarian CKD. A cross-sectional study was based on subjects who received physical checkups at Taipei Tzu Chi Hospital from 5 September 2005, 31 December 2016. All completed questionnaire their demographics,...
Advanced liver disease with massive damage may affect the metabolism of hypoglycemic agents and increase risk hypoglycemia. We conduct this research to compare severe hypoglycemia between patients type 2 diabetes, without compensated cirrhosis.From Taiwan's National Health Insurance Research Database, we identified persons diabetes cirrhosis (n = 18,209) 538,510) from January 1, 2000, December 31, 2010. Cox proportional hazards models were adopted assess risks all-cause mortality...
It is known that many medical adverse events can be caused by nonsteroidal anti-inflammatory drugs (NSAIDs); however, epidemiologic evidence has not granted an affirmative relationship between NSAID use and the risk of end-stage renal disease (ESRD). We aimed to investigate in a Chinese population short-term development ESRD requiring chronic dialysis. A retrospective case-crossover design was used this study. Using Taiwanese National Health Insurance database, we identified 109,400 incident...
Diabetes mellitus has become a major cause of death worldwide. Many technologies have available for managing diabetes and its complications. This study investigated the mortality trends in people with Taiwan between 2005 2014.We used data from Taiwan's National Health Insurance Research Database, which is linked to Death Registry. Patients at least three outpatient visits 1 year or one hospital admission diagnosis (International Classification Diseases, Ninth Revision, Clinical Modification...
Introduction Diabetes mellitus (DM) is a pathological hyperglycemic state related to the dysregulation of insulin. Chronic kidney disease (CKD) common chronic complication in diabetic patients. A vegetarian diet could be one preventive strategies for occurrence CKD patients with diabetes mellitus. However, it still unknown whether lowers DM Research Design and Methods This retrospective study was conducted at Taipei Tzu Chi Hospital from 5 September 2005 31 December 2016. Subjects an HbA1c...
Background The Taiwan Health Insurance Bureau has conducted a bundled payment system for hemodialysis reimbursement since 1995. maximum dose of erythropoiesis‐stimulating agents allowed by insurance is capped at 20 000 U epoetin or 100 μg darbepoetin alfa per month. Nephrologists have avoided the use high dosages to achieve hemoglobin level 10 11 g/dL iron supplementation. clinical impact these policies on patients’ outcomes unknown. authors aimed assess AIM‐HD (Association Anemia, Iron...
In recent years, the global incidence of type 2 diabetes in young people has increased, especially among minoritized, Indigenous, or financially disadvantaged populations. However, few studies have examined whether poverty is associated with increased risk youth-onset diabetes.To examine association family income level diabetes.This nationwide, population-based retrospective cohort study used data from 2008 National Health Insurance Research Database Taiwan, follow-up through December 31,...
Abstract Diabetes mellitus is a risk factor for Parkinson's disease (PD). While animal studies have supported the benefits of incretin-based therapies, including dipeptidyl peptidase-4 (DPP4) inhibitors, in PD, clinical research has yielded controversial results. This cohort study aimed to assess relationship between PD incidence and utilization DPP4 inhibitor diabetic patients. Using Taiwan's National Health Insurance Research Database from 2009 2018, patients receiving metformin plus at...
To investigate the risks of metabolic acidosis and renal outcomes after topical carbonic anhydrase inhibitor (CAI) use in patients with both primary open-angle glaucoma (POAG) advanced chronic kidney disease (CKD).Nationwide, population-based cohort study.This study was conducted population data from Taiwan's National Health Insurance (NHI) Research Database between January 2000 June 2009. Patients CKD who were diagnosed (International Classification Diseases, Ninth Revision [ICD-9] code...
Abstract Whether elevated serum uric acid levels (SUA) predict renal dysfunction remains controversial in the elderly. Therefore, we investigated association between SUA and early function decline defined as an estimated glomerular filtration rate (eGFR) reduction ≥30% over 2 years. From 2001 to 2010, conducted a longitudinal cohort study comprising 44,078 participants aged ≥65 years Taipei City Elderly Health Examination Database. Participants were classified by 1-mg/dL increment of SUA. We...
β-blocker (BB) dialyzability has been proposed to limit their efficacy among hemodialysis (HD) patients. We attempted confirm this hypothesis by comparing health outcomes associated with the initiation of dialyzable or nondialyzable BBs in a nationwide cohort HD patients.We created prospective study 15 699 patients who initiated (atenolol, acebutolol, metoprolol and bisoprolol) 20 904 (betaxolol, carvedilol propranolol) between 2004 2011 Taiwan healthcare. compared risk all-cause mortality...
Despite widespread use, there is no trial evidence to inform β-blocker's (BB) relative safety and efficacy among patients undergoing hemodialysis (HD). We herein compare health outcomes associated with carvedilol or bisoprolol the most commonly prescribed BBs in these patients. created a cohort study of 9305 HD who initiated 11 171 treatment between 2004 2011. compared risk all-cause mortality major adverse cardiovascular events (MACEs) users during 2-year follow-up. Bisoprolol initiators...
Several new antidiabetic drugs have been introduced in Taiwan. However, the trends treatment remain unexamined.We studied data from Taiwan National Health Insurance Database to identify outpatient prescriptions for 2005 2014. The patterns and number of different classes were analyzed. proportions monotherapy, combination therapy, or insulin therapy further analyzed.The total mean gradually increased during study period. Prescription oral (OADs) only insulin-only decreased slightly....
Abstract In 1996, the National Health Insurance Administration of Taiwan applied a restrictive reimbursement criteria for erythropoiesis-stimulating agents (ESAs) use in patients with chronic kidney disease. The maximal ESAs dosage allowed by insurance is capped at 20,000 U epoetin per month. Nephrologists avoided high ESA dosages to achieve hemoglobin level 10–11 g/dL using iron supplementation. We assessed association anemia and parameters mortality among peritoneal dialysis (AIM-PD)...
Limited studies have evaluated risk of stroke associated with the use NSAIDs in patients end-stage kidney disease. We examined adverse effects selective and nonselective NSAID on dialysis patients.A case-crossover study was conducted using medical claims data from National Health Insurance Research Database Taiwan. identified ischemic hemorrhagic (defined as International Classification Diseases, 9th revision, Clinical Modification codes 433, 434, 436 for 430 431 stroke) inpatient during...
Nonalcoholic fatty liver (NAFLD) and chronic kidney disease (CKD) share common pathogenic mechanisms risk factors. The relationship between in NAFLD CKD remains controversial. We aim to assess the association CKD.A cross-sectional study was based on individuals who received physical checkups at Taipei Tzu Chi Hospital from September 5, 2005, December 31, 2016. Demographic clinical characteristics of population were collected. defined by abdominal ultrasonography excluded other disease. as...
Metabolic syndrome is a subclinical status in promoting atherosclerotic cardiovascular disease and type 2 diabetes mellitus. The significance of metabolic pathophysiology chronic kidney not investigated.We enrolled adult patients with CKD stages 3 to 5 from December 2006 2007. was defined by the US National Cholesterol Education Programme Adult Treatment Panel III guidelines. Plasma levels angiogenic growth factors were measured. Univariate multivariate logistic regression analyses...