A5057988975- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Gastroesophageal reflux and treatments
- Esophageal Cancer Research and Treatment
- Eosinophilic Esophagitis
- Veterinary medicine and infectious diseases
- Gastrointestinal disorders and treatments
- Microscopic Colitis
- Colorectal Cancer Screening and Detection
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Galectins and Cancer Biology
- Esophageal and GI Pathology
- Genetic factors in colorectal cancer
- Cancer Cells and Metastasis
- Mass Spectrometry Techniques and Applications
- Inflammatory Bowel Disease
- Clostridium difficile and Clostridium perfringens research
- Oral Health Pathology and Treatment
- Gastrointestinal Bleeding Diagnosis and Treatment
- Cancer Research and Treatments
- Gastrointestinal motility and disorders
- Head and Neck Cancer Studies
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Surgical Treatments
Kaohsiung Medical University
2016-2025
National Yang Ming Chiao Tung University
2015-2025
Kaohsiung Medical University Chung-Ho Memorial Hospital
2016-2025
Taipei Institute of Pathology
2024
Taipei Municipal YangMing Hospital
2024
Kaohsiung Municipal Hsiao-Kang Hospital
2013-2020
Regenerative Medicine Institute
2020
Chang Gung Memorial Hospital
2019-2020
Kaohsiung Municipal Ta-Tung Hospital
2016-2019
National Sun Yat-sen University
2006-2018
<h3>Objective</h3> To develop and validate a clinical risk score predictive of for colorectal advanced neoplasia Asia. <h3>Methods</h3> A prospective, cross-sectional multicentre study was carried out in tertiary hospitals 11 Asian cities. The subjects comprise 2752 asymptomatic patients undergoing screening colonoscopy. From development set 860 colonoscopy, multiple logistic regression applied to identify significant factors defined as invasive carcinoma or adenoma. ORs were utilised...
Purpose: To prospectively evaluate accuracy of multi–detector row computed tomographic (CT) images for preoperative staging gastric cancer by using surgical and histopathologic results as reference standards. Materials Methods: This study had institutional review board approval; informed consent was obtained from all patients. Multi–detector CT included acquisition virtual gastroscopy after air distention contrast material–enhanced dynamic transverse multiplanar reformation (MPR) water...
Evidence suggests that ingesting lactic acid bacteria exerts a suppressive effect on Helicobacter pylori infection in both animals and humans. Supplementing with Lactobacillus- Bifidobacterium-containing yogurt (AB-yogurt) was shown to improve the rates of eradication H. humans.We administered AB-yogurt subjects asymptomatic test whether could inhibit growth.The vitro inhibition growth determined by inoculating Lactobacillus acidophilus La5 or Bifidobacterium lactis Bb12 plates were...
Abstract Background: Ten‐day sequential therapy with a proton pump inhibitor (PPI) and amoxicillin followed by PPI, clarithromycin, an imidazole typically achieves Helicobacter pylori eradication rates of 90–94% (Grade B success). Aims: We tested whether prolonging treatment continuing throughout the 14‐day period would produce ≥95% result. Methods: This was multicenter pilot study in which H. ‐infected patients received sequential–concomitant hybrid (esomeprazole for 7 days esomeprazole,...
Introduction Concerns have been raised regarding the potential association between proton pump inhibitor (PPI) use and dementia. Objective This study aimed to examine this in an Asian population. Methods Patients initiating PPI therapy January 1, 2000 December 31, 2003 without a prior history of dementia were identified from Taiwan’s National Health Insurance Research Database. The outcome interest was all-cause Cox regression models applied estimate hazard ratio (HR) cumulative dosage...
Vedolizumab (ENTYVIO) is a humanized α4β7 integrin antagonist approved for the treatment of inflammatory bowel disease, which selectively blocks gut-specific lymphocyte trafficking. We evaluated risk opportunistic infections interest in patients treated with vedolizumab.We determined frequency and tuberculosis receiving vedolizumab phase 3 clinical trials post-marketing settings. also adverse events reported setting history or concurrent hepatitis B/C virus infection.The incidence was 0.7...
The Asia-Pacific region has the largest number of cases colorectal cancer (CRC) and one highest levels mortality due to this condition in world. Since publishing two consensus recommendations 2008 2015, significant advancements have been made our knowledge epidemiology, pathology natural history adenoma-carcinoma progression. Based on most updated epidemiological clinical studies region, considering literature from international studies, adopting modified Delphi process, Working Group...
Abstract Background Owing to the heterogeneity of microbiota among individuals and populations, only Fusobacterium nucleatum Bacteroides fragilis have been reported be enriched in colorectal cancer (CRC) multiple studies. Thus, discovery additional bacteria contributing CRC development various populations can expected. We aimed identify associated with progression adenoma carcinoma determine contribution these malignant transformation patients Han Chinese origin. Methods Microbiota...
The gut microbiome and its metabolites are increasingly implicated in several cardiovascular diseases, but their role human myocardial infarction (MI) injury responses have yet to be established. To address this, we examined stool samples from 77 ST-elevation MI (STEMI) patients using 16 S V3-V4 next-generation sequencing, metagenomics machine learning. Our analysis identified an enriched population of butyrate-producing bacteria. These findings were then validated a controlled...
Importance Effects of screening for Helicobacter pylori on gastric cancer incidence and mortality are unknown. Objective To evaluate the effects an invitation to screen H mortality. Design, Setting, Participants A pragmatic randomized clinical trial residents aged 50 69 years in Changhua County, Taiwan, eligible biennial fecal immunochemical tests (FIT) colon screening. were either stool antigen (HPSA) + FIT assessment or alone. The study was conducted between January 1, 2014, September 27,...
Objective Live biotherapeutic products (LBPs) are biological composed of living micro-organisms, developed to prevent, treat, or cure diseases. Examples include cultured strains Akkermansia muciniphila and Christensenella minuta , as well treatments using purified Firmicutes spores for recurrent Clostridioides difficile infections. There is a need guidelines over the increasing interest in developing LBPs. A panel microbiome experts from Asia-Pacific countries articulates their perspectives...
The risks of betel quid chewing with or without tobacco, alcohol drinking and cigarette smoking have been well explored in the oral cavity but not pharynx larynx. We conducted a case-control study to investigate association these three risk factors cancers larynx Taiwan. A total cases 148 pharyngeal cancer, 128 laryngeal cancer 255 hospital controls, all men, were recruited. Betel was significant independent factor (adjusted odds ratio [aOR] = 7.7; 95% confidence interval [CI] 4.1-15.0)...
Abstract The consumption of alcohol, tobacco and betel quid has been found to be an important contributor esophageal squamous cell carcinoma (ESCC) in Taiwan. genotoxic effect the ADH1B ALDH2 genes modulating individual's alcohol‐metabolizing capacity on ESCC may linked drinking behavior, intake pattern other exogenous factors. To investigate interplay these genetic environmental factors determining risk ESCC, a multicenter case‐control study was conducted. Here, 406 patients with...
ObjectivesThis prospective study was designed to determine the efficacy of a levofloxacin-based rescue therapy for Helicobacter pylori infection after failure standard triple therapies. We also surveyed predictors this therapy.
// Tsung-Hua Hsieh 5 , Chia-Yi Hsu 1 Cheng-Fang Tsai Cheng-Yu Long Chee-Yin Chai 3 Ming-Feng Hou 4 Jau-Nan Lee Deng-Chyang Wu 6 Shao-Chun Wang 7 Eing-Mei 1, 2, 5, Graduate Institute of Medicine, College Kaohsiung Medical University, 80708, Taiwan 2 Center for Research Resources and Development, Department Pathology, University Hospital, General Surgery, Obstetrics Gynecology, Stem Cell Research, Cancer Biology, Cincinnati, Ohio 45267, USA Correspondence to: Tsai, e-mail: tsaieing@yahoo.com...
Cetuximab, a monoclonal antibody targeting epidermal growth factor receptor (EGFR), has been proven to be efficient in metastatic colorectal cancer (mCRC); however, the therapeutic response is variable and markers predictive of are urgently required. This study was conducted determinate values KRAS mutation status EGFR expression mCRC patients treated with cetuximab plus chemotherapy.Clinical benefit EGFR-targeting antibodies seems restricted particular subgroup patients. Therefore,...
Abstract Background Bismuth quadruple therapy is the treatment of choice for first‐line Helicobacter pylori infection in areas high clarithromycin resistance. Currently, impact promising on gut microbiota remains unclear. Aim To investigate short‐term and long‐term impacts bismuth microbiota. Methods Adult patients with H. ‐related gastritis were treated 14‐day therapy. Fecal samples collected before at week 2, 8, 48. Nucleic acid extraction from fecal was performed. The V3‐V4 region...
Recent studies indicate that a high level of nesfatin-1/Nucleobindin-2 (NUCB-2) is associated with poor outcome and promotes cell migration in breast cancer prostate cancer. However, the role NUCB2 not well known colon In this study, NUCB-2 tissue was higher than non-tumor tissue. Suppression line SW620 inhibited invasion. The microarray analysis showed low expression transcription factor ZEB1 knockdowned cells. addition, epithelial-mesenchymal transition (EMT)-related molecules including...