A5029127365- Genomics and Phylogenetic Studies
- Bioinformatics and Genomic Networks
- Gut microbiota and health
- Robotics and Sensor-Based Localization
- Aquaculture disease management and microbiota
- RNA and protein synthesis mechanisms
- vaccines and immunoinformatics approaches
- Advanced Vision and Imaging
- Gene expression and cancer classification
- Hepatitis C virus research
- Robotic Mechanisms and Dynamics
- Aquaculture Nutrition and Growth
- Antimicrobial Peptides and Activities
- Liver Disease Diagnosis and Treatment
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Chromosomal and Genetic Variations
- Protein Structure and Dynamics
- Neurobiology and Insect Physiology Research
- Iterative Learning Control Systems
- Reproductive biology and impacts on aquatic species
- Microbial Metabolic Engineering and Bioproduction
- Clostridium difficile and Clostridium perfringens research
- Image Processing Techniques and Applications
- Crustacean biology and ecology
- Advanced Measurement and Metrology Techniques
Linkou Chang Gung Memorial Hospital
2025
Chang Gung University
2024-2025
Chang Gung Memorial Hospital
2024-2025
National Yang Ming Chiao Tung University
2024
Taipei Veterans General Hospital
2024
Institute of Information Science, Academia Sinica
2015-2024
National Taiwan University
2009-2024
Academia Sinica
2012-2024
National Taiwan Ocean University
2024
Yuan Ze University
2023
Network is a useful way for presenting many types of biological data including protein-protein interactions, gene regulations, cellular pathways, and signal transductions. We can measure nodes by their network features to infer importance in the network, it help us identify central elements networks.We introduce novel Cytoscape plugin cytoHubba ranking features. CytoHubba provides 11 topological analysis methods Degree, Edge Percolated Component, Maximum Neighborhood Density Maximal Clique...
Whether the Amborella/Amborella-Nymphaeales or grass lineage diverged first within angiosperms has recently been debated. Central to this issue focused on artifacts that might result from sampling only grasses monocots. We therefore sequenced entire chloroplast genome (cpDNA) of Phalaenopsis aphrodite, Taiwan moth orchid. The cpDNA is a circular molecule 148,964 bp with comparatively short single-copy region (11,543 bp) due unusual loss and truncation/scattered deletion certain ndh subunits....
One major task in the post-genome era is to reconstruct proteomic and genomic interacting networks using high-throughput experiment data. To identify essential nodes/hubs these interactomes a way decipher critical keys inside biochemical pathways or complex networks. These may serve as potential drug-targets for developing novel therapy of human diseases, such cancer infectious disease caused by emerging pathogens. Hub Objects Analyzer ( Hubba ) web-based service exploring important nodes an...
Abstract Genetic research on influenza virus biology has been informed in large part by nucleotide variants present seasonal or pandemic samples, individual mutants generated the laboratory, leaving a substantial of genome uncharacterized. Here, we have developed single-nucleotide resolution genetic approach to interrogate fitness effect point mutations 98% amino acid positions A hemagglutinin (HA) gene. Our HA map provides reference identify indispensable regions aid drug and vaccine design...
Phosphaturic mesenchymal tumours (PMTs) are uncommon soft tissue and bone that typically cause hypophosphataemia tumour-induced osteomalacia (TIO) through secretion of phosphatonins including fibroblast growth factor 23 (FGF23). PMT has recently been accepted by the World Health Organization as a formal tumour entity. The genetic basis oncogenic pathways underlying its tumourigenesis remain obscure. In this study, we identified novel FN1-FGFR1 fusion gene in three out four PMTs...
With the development of robotics, there are growing needs for real time motion planning. However, due to obstacles in environment, planning problem is highly nonconvex, which makes it difficult achieve computation using existing nonconvex optimization algorithms. This paper introduces convex feasible set algorithm, a fast algorithm problems that have costs and constraints. The idea find original iteratively solve sequence subproblems feasibility convergence proposed proved paper. application...
Antimicrobial peptides (AMPs) are innate immune components that have recently stimulated considerable interest among drug developers due to their potential as antibiotic substitutes. AMPs notable for fundamental properties of microbial membrane structural interference and the biomedical applications killing or suppressing microbes. New AMP candidates must be developed oppose resistance. However, discovery novel through wet-lab screening approaches is inefficient expensive. The prediction...
Abstract Background Owing to the heterogeneity of microbiota among individuals and populations, only Fusobacterium nucleatum Bacteroides fragilis have been reported be enriched in colorectal cancer (CRC) multiple studies. Thus, discovery additional bacteria contributing CRC development various populations can expected. We aimed identify associated with progression adenoma carcinoma determine contribution these malignant transformation patients Han Chinese origin. Methods Microbiota...
There are still no effective therapies for hyposalivation caused by irradiation. In our previous study, bone marrow stem cells can be transdifferentiated into acinar-like in vitro. Therefore, we hypothesized that transplantation with or may help functional regeneration of salivary glands. Bone were labeled nanoparticles and directly co-cultured acinar to obtain cells. total, 140 severely combined immune-deficiency mice divided 4 groups cell therapy experiments: (1) normal mice, (2) receiving...
Widely used chemical genetic screens have greatly facilitated the identification of many antiviral agents. However, regions interaction and inhibitory mechanisms therapeutic candidates yet to be elucidated. Previous identified Daclatasvir (BMS-790052) as a potent nonstructural protein 5A (NS5A) inhibitor for Hepatitis C virus (HCV) infection with an unclear mechanism. Here we developed quantitative high-resolution (qHRG) approach systematically map drug-protein interactions between NS5A...
Development of colorectal cancer (CRC) involves sequential transformation normal mucosal tissues into benign adenomas and then malignant tumors. The identification genes crucial for in (CRAs) has been based primarily on cross-sectional observations. In this study, we identified relevant using autologous samples. By performing genome-wide SNP genotyping RNA sequencing analysis adenocarcinomas, adenomatous polyps, non-neoplastic colon (referred as tri-part samples) from individual patients, 68...
Antiviral peptides (AVPs) from various sources suggest the possibility of developing peptide drugs for treating viral diseases. Because increasing number identified AVPs and advances in deep learning theory, it is reasonable to experiment with drug design using silico methods.We collected most up-to-date used construct a sequence-based binary classifier. A generative adversarial network was employed augment positive training dataset enable our convolutional neural (CNN) model learn negative...
Because of the growing number clinical antibiotic resistance cases in recent years, novel antimicrobial peptides (AMPs) may be ideal for next-generation antibiotics. This study trained a Wasserstein generative adversarial network with gradient penalty (WGAN-GP) based on known AMPs to generate AMP candidates. The quality GAN-designed was evaluated silico, and eight them, named GAN-pep 1-8, were selected by an Artificial Intelligence (AI) classifier synthesized further experiments. Disc...
Background and Aims: Unlike other malignancies, hepatic functional reserve competes with tumor progression in determining the risk of mortality from hepatocellular carcinoma (HCC). However, relative contribution decompensation over influencing overall survival (OS) has not been assessed combination immunotherapy recipients. Approach Results: From AB-real observational study (n = 898), we accrued 571 patients advanced/unresectable carcinoma, Child-Pugh A class treated frontline atezolizumab +...
Abstract Although rising ocean temperatures threaten scleractinian corals and the reefs they construct, certain reef can acclimate to elevated which are rarely exposed in situ . Specimens of model Indo‐Pacific coral Pocillopora damicornis collected from upwelling Southern Taiwan were previously found have survived a 36‐week exposure 30°C, temperature encounter infrequently one that elicit breakdown coral–dinoflagellate (genus S ymbiodinium ) endosymbiosis many Pacific Ocean. To gain insight...
With the rapid increase in genome sequencing projects for non-model organisms, numerous assemblies are currently progress or available as drafts, but not made satisfactory, usable genomes. Data quality assessment of is gaining importance only people who perform assembly/re-assembly processes, also those attempt to use maps downstream analyses. Recent studies control, evaluation/ have focused on either control reads before evaluation with respect their contiguity and correctness. However,...
Depression is associated with gut dysbiosis that disrupts a gut-brain bidirectional axis. Gray matter volume changes in cortical and subcortical structures, including prefrontal regions the hippocampus, have also been noted depressive disorders. However, link between microbiota brain structures depressed patients remains elusive. Neuropsychiatric measures, stool samples, structural images were collected from 36 late-life depression (LLD) 17 healthy controls. 16S ribosomal RNA (rRNA) gene...
Studies have reported the effects of gut microbiota on colorectal cancer (CRC) chemotherapy, but few studies investigated association between and targeted therapy. This study role in treatment outcomes patients with metastatic CRC (mCRC). We enrolled 110 mCRC treated them standard Stool samples were collected before administering a combination chemotherapy Patients who had progressive disease (PD) or partial response (PR) for at least 12 cycles therapy included study. further divided these...
The survival benefit of direct-acting antiviral (DAA) therapy for hepatitis C virus (HCV) infection in patients with hepatocellular carcinoma (HCC), particularly BCLC stages B/C, remains largely uncertain. We aimed to explore the impact DAA on overall (OS) HCC using a nationwide cohort study. utilized Taiwan Association Study Liver (TASL) HCV Registry (TACR) database include all adults receiving HCV, excluding those other viral infections, liver transplantation, non-HCC malignancies, and...