A5009738321- Bone health and osteoporosis research
- Hip and Femur Fractures
- Bone health and treatments
- Bone Metabolism and Diseases
- Orthopaedic implants and arthroplasty
- Sarcoma Diagnosis and Treatment
- Nutrition and Health in Aging
- Total Knee Arthroplasty Outcomes
- Cell Adhesion Molecules Research
- Bone and Joint Diseases
- Bone fractures and treatments
- Orthopedic Infections and Treatments
- Protease and Inhibitor Mechanisms
- Management of metastatic bone disease
- Inflammatory mediators and NSAID effects
- Cancer Diagnosis and Treatment
- Spine and Intervertebral Disc Pathology
- Frailty in Older Adults
- Hip disorders and treatments
- Thyroid Disorders and Treatments
- Ultrasound and Hyperthermia Applications
- Scoliosis diagnosis and treatment
- Knee injuries and reconstruction techniques
- Bone Tumor Diagnosis and Treatments
- Muscle Physiology and Disorders
National Taiwan University Hospital
2016-2025
Wuhou District People's Hospital, Chengdu
2024
Guangdong Provincial People's Hospital
2024
Nanjing Drum Tower Hospital
2007-2024
Nanjing University of Chinese Medicine
2024
Nantong Maternity and Child Health Hospital
2024
Nantong University
2024
Jianghan University
2024
Guangdong Academy of Medical Sciences
2024
Southern Medical University
2024
Iodine is an essential component of thyroid hormones; either low or high intake may lead to disease. We observed increase in the prevalence overt hypothyroidism, subclinical and autoimmune thyroiditis with increasing iodine China cohorts from three regions different levels intake: mildly deficient (median urinary excretion, 84 microg per liter), more than adequate (median, 243 excessive 651 liter). Participants enrolled a baseline study 1999, during five-year follow-up through 2004, we...
Background: There is a variety of treatment modalities for unicameral bone cysts, with variable outcomes reported in the literature. Although good initial have been reported, success rate has often changed longer-term follow-up. We introduce novel, minimally invasive method and compare its clinical those other methods this lesion. Methods: From February 1994 to April 2008, forty patients cyst were treated one four techniques: serial percutaneous steroid autogenous bone-marrow injection...
To identify estrogen and progesterone target cells in the human anterior cruciate ligament immunohistochemical localization of both receptors was performed 17 specimens ligament. All were obtained at surgery. Thirteen from women, four men: average age 57 years (range, 18-78 years). Eleven (from nine women two men) came total knee replacements for osteoarthritis knee: three one man), reconstructions ligament: (both women), medial meniscectomies; a an amputation secondary to chondrosarcoma...
Abstract Articular adipose tissue is a ubiquitous component of human joints, and adiponectin protein hormone secreted predominantly by differentiated adipocytes involved in energy homeostasis. We investigated the signaling pathway IL-6 production caused both rheumatoid arthritis synovial fibroblasts osteoarthritis fibroblasts. Rheumatoid expressed AdipoR1 AdipoR2 isoforms receptor. Adiponectin concentration- time-dependent increases production. Adiponectin-mediated was attenuated...
Objectives— Diabetes mellitus causes endothelial dysfunction. The precise molecular mechanisms by which hyperglycemia apoptosis in cells are not yet well understood. aim of this study was to explore the role cyclooxygenase-2 (COX-2) and possible involvement phosphoinositide 3-kinase (PI3K) signaling high glucose (HG)–induced human umbilical vein (HUVECs). Methods Results— For detection apoptosis, morphological Hoechst staining Annexin V/propidium iodide were used. Glucose upregulated COX-2...
It has been shown that ultrasound (US) stimulation accelerates fracture healing in animal models and clinical studies. Here we found US transiently increased the surface expression of α2, α5, β1, β3 integrins cultured osteoblasts, as by flow cytometric analysis immunofluorescence staining. prostaglandin E<sub>2</sub> formation protein mRNA levels cyclooxygenase-2 (COX-2). At mechanistic level, anti-integrin α5β1 αvβ3 antibodies or rhodostomin, a snake venom disintegrin, attenuated US-induced...
In a follow-up study, we determined the prevalence, incidence, and natural course of positive antithyroperoxidase antibodies (TPOAbs) antithyroglobulin (TgAbs) in general population examined influences iodine intake.The study was conducted Panshan, Zhangwu, Huanghua, regions with mildly deficient, more than adequate, excessive intake, respectively. Of 3761 unselected subjects who were enrolled at baseline, 3018 participated 5-yr study. Serum TSH, TPOAb, TgAb levels measured.Among prevalence...
<i>Purpose:</i> To investigate the possible prognostic factors of survival outcomes in patients with granulocytic sarcoma (GS). <i>Methods:</i> We retrospectively investigated determining 24 GS using Kaplan-Meier analysis followed by log rank tests. evaluated gender, age, location, antedating leukemia, underlying disorders, treatment type and stem cell transplantation. <i>Results:</i> The 5-year rate for was 21%. undergoing chemotherapy had a significantly...
Leptin, the adipocyte-secreted hormone that centrally regulates weight control, is known to function as an immunomodulatory regulator. We investigated signaling pathway involved in IL-6 production caused by leptin microglia. Microglia expressed long (OBRl) and short (OBRs) isoforms of receptor. Leptin concentration- time-dependent increases production. Leptin-mediated was attenuated OBRl receptor antisense oligonucleotide, PI3K inhibitor (Ly294002 wortmannin), Akt...
Abstract Background Few randomized controlled trials (RCTs) report interventions targeting improvement of frailty status as an outcome. Methods This RCT enrolled 117 older adults (65-79 years age) in Toufen, Taiwan who scored 3-6 on The Chinese Canadian Study Health and Aging Clinical Frailty Scale Telephone Version then score ≥1 the Cardiovascular Phenotypic Classification (CHS_PCF). With a two by factorial design, subjects were randomly assigned to (Exercise nutrition, EN, n = 55 or...
Abstract Diabetic myopathy, a less studied complication of diabetes, exhibits the clinical observations characterized by muscle mass, weakness and reduced physical functional capacity. Accumulation advanced glycation end‐products ( AGEs ), known to play role in diabetic complications, has been identified ageing human skeletal muscles. However, myopathy remains unclear. Here, we investigated effects on myogenic differentiation atrophy vivo vitro . We also evaluated therapeutic potential...
Obesity is a risk factor for prostate cancer development, but the underlying mechanism unknown. The present study tested hypothesis that stromal cells of adipose tissue might be recruited by to help tumor growth.PC3 were transplanted into subcutaneous space right flank athymic mice. One week later, tissue-derived or stem (ADSC) phosphate-buffered saline (PBS, as control) was similarly left flank. Tumor size monitored next 34 days; afterwards, mice sacrificed and their tumors harvested...
Between September 1984 and January 1996, 32 expandable endoprostheses were used for limb reconstruction after resection of malignant bone tumors in patients who skeletally immature. The 20 boys 12 girls ranged age from 3 to 15 years (mean, 9.7 years). One patient had a Stage IIA tumor, 22 IIB tumors, seven III according the classification Musculoskeletal Tumor Society. There also two with parosteal osteosarcomas. histologic diagnosis was osteosarcoma 23 Ewing's sarcoma nine. All except...
Weight bearing during exercise plays an important role in improving the mechanical properties of bone. The effect on bone non-weight-bearing such as swimming remains controversial. To investigate effects mode growing bone, 29 male Wistar rats (7 wk old) were randomly assigned to a running group (Run, n = 9), (Swim, 10), or nonexercise control (Con, 10). During 8-wk training session (20-60 min/day, 5 days/wk), Run trained at progressively increasing speeds (12-22 m/min), and weights attached...
Lung caner cells have a striking tendency to metastasize bone. The chemokine stromal cell-derived factor-1 (SDF-1) is constitutively secreted by osteoblasts and bone marrow plays key role for homing of hematopoietic the marrow. Reverse transcriptase–polymerase chain reaction flow cytometry studies demonstrated SDF-1 receptor (CXCR4) messenger RNA (mRNA) surface expression CXCR4 in lung cancer cell lines, especially higher those with high invasiveness (A549) as compared lower level H928 H1299...
The relationship between oxidation stress and phosphoinositide 3-kinase (PI3K) signaling in pancreatic beta-cell dysfunction remains unclear. Mercury is a well-known toxic metal that induces oxidative stress. Submicromolar-concentration HgCl(2) or methylmercury triggered reactive oxygen species (ROS) production decreased insulin secretion beta-cell-derived HIT-T15 cells isolated mouse islets. increased PI3K activity its downstream effector Akt phosphorylation. Antioxidant N-acetyl-l-cysteine...
Of 125 patients with traumatic dislocation of the hips treated, 96 were reviewed retrospectively; 80 males and 16 females an age range from seven to 81 years (mean, 33.5 years). Motorcycle accidents leading cause in this series (40 cases, 42%). Associated injuries found 68 cases (70.8%). Seventyseven (80%) reduced within 24 hours. In follow-up periods ranging 15 months 18 7.5 years), 56 had excellent or good results (58.3%). Statistical analysis clinical showed that those simple dislocations...