A5066928151- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- Hepatocellular Carcinoma Treatment and Prognosis
- Respiratory Support and Mechanisms
- Cystic Fibrosis Research Advances
- Liver Disease Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Pneumonia and Respiratory Infections
- COVID-19 Clinical Research Studies
- Cancer Genomics and Diagnostics
- Allergic Rhinitis and Sensitization
- Coronary Interventions and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- Obstructive Sleep Apnea Research
- Tracheal and airway disorders
- Liver Disease and Transplantation
- COVID-19 and healthcare impacts
- Cardiac and Coronary Surgery Techniques
- Respiratory viral infections research
- Italian Literature and Culture
- Linguistic Studies and Language Acquisition
- Colorectal Cancer Treatments and Studies
- Hepatitis C virus research
University of Palermo
2016-2025
Bocconi University
2025
Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo
2018-2024
University of Douala
2018
Regionshospitalet Viborg
2018
Respiratory Clinical Trials
2018
Ospedale Vincenzo Cervello
2010
Hôpital Européen
2001-2009
Hôpital Européen Georges-Pompidou
2001-2009
In-Q-Tel
2009
Extracellular matrix (ECM) composition has an important role in determining airway structure. We postulated that ECM lung of chronic obstructive pulmonary disease (COPD) patients differs from observed smoking and nonsmoking subjects without airflow obstruction. determined the fractional areas elastic fibres, type-I, -III -IV collagen, versican, decorin, biglycan, lumican, fibronectin tenascin different compartments large small airways parenchyma 26 COPD patients, smokers 16 control subjects....
Summary The cross‐sectional relationship of obstructive sleep apnea with moderate to severe chronic kidney disease, defined as an estimated glomerular filtration rate <60 mL min −1 ∙1.73 m −2 , was investigated in a large cohort patients suspected studied by nocturnal polysomnography or cardiorespiratory polygraphy. Data were obtained from the European Sleep Apnea Database, where information unselected adult afferent 26 centres had been prospectively collected. Both Modification Diet...
Atezolizumab (ATEZO) plus bevacizumab (BEVA) represents the new standard of care for treatment advanced hepatocellular carcinoma (HCC). However, choice second-line after failure immunotherapy-based first-line remains elusive. Taking into account weaknesses available evidence, we developed a simulation model based on phase III randomized clinical trials (RCTs) to identify optimal risk/benefit sequential strategies.A Markov was built estimate overall survival (OS) first- and systemic...
Long-term exposure to air pollution has adverse respiratory health effects. We investigated the cross-sectional relationship between residential pollutants and risk of suffering from chronic diseases in some Italian cities. In BIGEPI project, we harmonised questionnaire data two population-based studies conducted 2007-2014. By combining self-reported diagnoses, symptoms medication use, identified cases rhinitis (n = 965), asthma 328), bronchitis/chronic obstructive pulmonary disease...
Background and Aims: Unlike other malignancies, hepatic functional reserve competes with tumor progression in determining the risk of mortality from hepatocellular carcinoma (HCC). However, relative contribution decompensation over influencing overall survival (OS) has not been assessed combination immunotherapy recipients. Approach Results: From AB-real observational study (n = 898), we accrued 571 patients advanced/unresectable carcinoma, Child-Pugh A class treated frontline atezolizumab +...
Background Nitric oxide (NO) donors, in addition to their vasodilator effect, decrease platelet aggregation and inhibit vascular smooth muscle cell proliferation. These actions could have beneficial effects on restenosis after coronary balloon angioplasty. Methods Results In a prospective multicenter, randomized trial, 700 stable patients scheduled for angioplasty received direct NO donors (infusion of linsidomine followed by oral molsidomine) or diltiazem. Treatment was started before...
<b>Background:</b> Several studies suggest that the periphery of lung is major site inflammation in asthma. Fractional exhaled nitric oxide (Feno) and 8-isoprostane have been proposed as biomarkers oxidative stress. We therefore hypothesised small airway dysfunction asthma inflammatory origin can be detected by molecular markers air. To test this hypothesis, we examined relationship Feno air with airways function assessed single breath nitrogen test. <b>Methods:</b> Sixteen patients (14...
Airway inflammation in asthma involves both large and small airways, the combination of inhaled corticosteroids (ICS) long acting beta-2 agonists (LABA) is mainstay therapy. Available combinations differ terms drug delivery to lung ability reach airways.To evaluate whether treatment with an extra-fine provides additional effects vs a nonextra-fine on airway function.After 1- 4-week run-in period, patients were randomized double blind, dummy, 12-week either beclomethasone/formoterol (BDP/F)...
Summary Obstructive sleep apnea often coexists with visceral adiposity and metabolic syndrome. In this study, we analysed gender‐related differences in anthropometrics according to severity abnormalities. addition, the index, a recently introduced marker of cardiometabolic risk, was analysed. Consecutive subjects suspected obstructive ( n = 528, 423 males, mean age ± standard deviation: 51.3 12.8 years, body mass index: 31.0 6.2 kg m −2 ) were studied by full polysomnography (apnea–hypopnea...
<b><i>Background and Objective:</i></b> We aimed to explore what extent an unselected population of chronic obstructive pulmonary disease (COPD) outpatients would be eligible for inclusion in randomized clinical trials (RCTs). <b><i>Methods:</i></b> Retrospective analysis the records outpatient subjects with ascertained diagnosis COPD. COPD were assessed against following criteria: 40 < age 80 years, current or former smokers, forced...
Implantation of a transjugular intrahepatic portosystemic shunt (TIPS) improves survival in patients with cirrhosis refractory ascites and portal hypertensive bleeding. However, the indication for TIPS older adult (greater than or equal to 70 years) is debated, specific prediction model developed this particular setting lacking. The aim study was develop validate multivariable an accurate mortality adults.We prospectively enrolled 411 consecutive observed at four referral centers de novo...
Bronchiectasis is a chronic respiratory disease characterised by an abnormal dilation of the bronchi associated with clinical syndrome daily productive cough and history frequent exacerbations [1]. Although bronchiectasis awareness has increased over past decades, underestimation this still exists across different settings healthcare professionals [2]. A diagnostic delay seems to exist in bronchiectasis, ranging from 12 17 years, might lead progression worsen patients' outcomes [3, 4, 5]. It...
Early diagnosis of idiopathic pulmonary fibrosis (IPF) is fundamental to slow disease progression; multidisciplinary teams (MDTs) play a central role in posing the final IPF, thus aiming improve patient outcomes. However, practical implementation MDTs clinical real-life settings may be hindered by lack local expertise or time constraints, with being made without support complementary professional health care figures. This study aims evaluate impact MDT meetings on latency between symptom...