A5025969713- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory and Cough-Related Research
- Lung Cancer Treatments and Mutations
- Pleural and Pulmonary Diseases
- Lung Cancer Diagnosis and Treatment
- Inhalation and Respiratory Drug Delivery
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Research Studies
- Respiratory Support and Mechanisms
- Sarcoidosis and Beryllium Toxicity Research
- Colorectal Cancer Treatments and Studies
- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Long-Term Effects of COVID-19
- Immune Response and Inflammation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- SARS-CoV-2 and COVID-19 Research
- Immune Cell Function and Interaction
- Immune cells in cancer
- Nutrition and Health in Aging
- Obstructive Sleep Apnea Research
- Cell Adhesion Molecules Research
- Inflammatory mediators and NSAID effects
- Cancer Genomics and Diagnostics
University of Palermo
2005-2021
Ospedale Vincenzo Cervello
2007-2016
University of Calgary
1999-2003
National Research Council
2003
I.R.C.C.S. Oasi Maria SS
2000
University of Michigan
1999
National Academies of Sciences, Engineering, and Medicine
1992
University of Padua
1990
The Ohio State University
1988
To study the prognostic value for overall survival of baseline assessment functional status, comorbidity, and quality life (QoL) in elderly patients with advanced non-small-cell lung cancer treated chemotherapy.Data from 566 enrolled onto phase III randomized Multicenter Italian Lung Cancer Elderly Study (MILES) were analyzed. Functional status was measured as activities daily living (ADL) instrumental ADL (IADL). The presence comorbidity assessed a checklist 33 items; items 29 30 European...
Pain is a highly distressing symptom for patients with advanced cancer. WHO analgesic ladder widely accepted as guideline its treatment. Our aim was to describe pain prevalence among diagnosed non-small-cell lung cancer (NSCLC), impact of on quality life (QoL) and adequacy management. Data 1021 Italian enrolled in three randomised trials chemotherapy NSCLC were pooled. QoL assessed by EORTC QLQ-C30 LC-13. Analgesic consumption during the 3 weeks following assessment recorded. Adequacy...
Our objectives were to test the hypothesis that, in geriatric population, chronic airway obstruction is associated with a higher prevalence of sleep disturbances; identify main correlates disturbances, and verify whether asthma COPD patients have different patterns disturbances. The EPESE questionnaire was administered 734 aged 65 years over or obstructive pulmonary disease (cases) 1237 individuals comparable age who free respiratory but not other conditions (controls). Four disturbances...
Airway inflammation in asthma involves both large and small airways, the combination of inhaled corticosteroids (ICS) long acting beta-2 agonists (LABA) is mainstay therapy. Available combinations differ terms drug delivery to lung ability reach airways.To evaluate whether treatment with an extra-fine provides additional effects vs a nonextra-fine on airway function.After 1- 4-week run-in period, patients were randomized double blind, dummy, 12-week either beclomethasone/formoterol (BDP/F)...
The pleural space is a potential compartment between the lung and chest wall that becomes filled with fluid inflammatory cells in number of respiratory diseases. In an attempt to understand one aspect process space, we compared responses three different diseases (congestive heart failure [CHF], tuberculosis [TB], cancer). Large concentrations interleukin-8 (IL-8) were detected cancer TB effusions, but not CHF. Surprisingly, concentration IL-8 correlated best lymphocyte recruitment neutrophil...
Background/Objective: This study was aimed at exploring to what extent populations enrolled in randomized controlled trials (RCTs) of inhalation combination treatment for mild/moderate asthma adults are fully representative ‘real-life' populations. The following is a retrospective analysis the clinical records outpatient subjects with an ascertained diagnosis asthma. Methods: A performed. Stable conditions, such as smoking habit and chronic diseases other than asthma, were identified...
The mainstay of management in asthma is inhalation therapy at the target site, with direct delivery aerosolized drug into airways to treat inflammation and relieve obstruction. Abundant evidence available support concept that inflammatory functional changes level most peripheral strongly contribute complexity heterogeneous manifestations asthma. It now largely accepted there a wide range clinical phenotypes disease, characterized primarily by small involvement. Thus, an appropriate...
Chronic obstructive pulmonary disease (COPD) and ageing may contribute to malnutrition. We aimed explore whether COPD determine malnutrition in different manners. 460 stable outpatients (376 males 84 females) from the Extrapulmonary Consequences of Elderly (ECCE) study database were investigated (age 75.0±5.9 yrs; forced expiratory volume 1 s 54.7±18.3% predicted). Nutritional status was evaluated using Mini Assessment® (MNA) questionnaire. From MNA, three scores exploring domains...
The purpose of this study was to evaluate the effect theophylline on tumour necrosis factor-alpha (TNF-alpha) release by human blood monocytes (BMo), and rat BMo alveolar macrophages (AM). AM were incubated in absence or presence theophylline, cell-free supernatants harvested tested for TNF-alpha activity bioassay. Theophylline dose-dependently reduced BMo: significant inhibition observed at 100 microns (41 +/- 5.9% controls) 50 (59 4.8% controls), while inhibitory 10 (71 8.9% not...
Intercellular adhesion molecule-1 (ICAM-1) is an molecule that plays a crucial role in cell–cell interactions involved the recruitment of cells and immune responses. Under some circumstances, ICAM-1 found as soluble protein has potential to influence nature immunoinflammatory By examining fluid from pleural compartment patients with cancer, tuberculosis, congestive heart failure, cellular source, conformation, control, biological activity (sICAM-1) were investigated. The results suggest...
In asthmatic subjects an imbalance between elastase and α<sub>1</sub>‐antitrypsin (α<sub>1</sub>‐PI) exists. This study aims to evaluate whether ageing <i>per se</i> affects the levels of elastase. Both young elderly asthmatics with comparable severity duration disease, as well healthy subjects, underwent induced sputum procedure measure α<sub>1</sub>‐PI. The percentage neutrophils eosinophils was higher in than controls. both total active were significantly controls, directly correlated...
SUMMARY The pleural space is a virtual compartment between the lung and chest wall that becomes filled with fluid inflammatory cells during variety of respiratory diseases. Here, we study potential role eicosanoid metabolite leukotriene B4 (LTB4) in disparate diseases leading to acute (pneumonia) or chronic (tuberculosis, cancer) inflammation space. LTB4 concentrations were significantly higher due pneumonia, tuberculosis cancer respect congestive heart failure correlated neutrophil...
Gemcitabine is a chemotherapy agent commonly used in the treatment of non-small cell lung cancer (NSCLC) that has been demonstrated to induce apoptosis NSCLC cells by increasing functionally active Fas expression. The aim this study was evaluate Fas/Fas ligand (FasL) system involvement gemcitabine-induced killing. H292 were cultured presence or absence gemcitabine. FasL mRNA and protein evaluated real-time PCR, Western blot flow cytometry, respectively. Apoptosis FasL-expressing caspase-8...
Intercellular adhesion molecule-1 (ICAM-1) expression by tumour cells may be involved in their interaction with defensive cells. In this study the surface ICAM-1 and soluble (sICAM-1) production five small cell lung cancer (SCLC) non-SCLC (NSCLC) lines was investigated. addition, effects of upregulation cytokines on to allogeneic lymphokine-activated killer (LAK) susceptibility LAK cytotoxicity also evaluated. assessed flow cytometry. Soluble release measured enzyme-linked immunosorbent...