A5005223776- Heart Rate Variability and Autonomic Control
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cardiac Ischemia and Reperfusion
- Blood Pressure and Hypertension Studies
- Cardiovascular and exercise physiology
- Heart Failure Treatment and Management
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac pacing and defibrillation studies
- Frailty in Older Adults
- Dementia and Cognitive Impairment Research
- Cardiac Arrhythmias and Treatments
- Cardiac Arrest and Resuscitation
- Receptor Mechanisms and Signaling
- Metabolism, Diabetes, and Cancer
- Cardiac Health and Mental Health
- ECG Monitoring and Analysis
- Hormonal Regulation and Hypertension
- Adipose Tissue and Metabolism
- Intensive Care Unit Cognitive Disorders
- Eicosanoids and Hypertension Pharmacology
- Cardiomyopathy and Myosin Studies
- Anesthesia and Neurotoxicity Research
Istituti Clinici Scientifici Maugeri
2004-2018
University of Naples Federico II
2005-2017
Fondazione Salvatore Maugeri
2007-2017
Istituti di Ricovero e Cura a Carattere Scientifico
1998-2017
Casa Sollievo della Sofferenza
2009-2017
Tecnologie Avanzate (Italy)
2017
University of Bari Aldo Moro
2017
Nova Southeastern University
2015
Temple University
2015
Federico II University Hospital
1999-2013
Abstract Background The elderly are characterized by a high prevalence of chronic heart failure (CHF) and frailty, which is complex interaction physical, psychological social impairment. This study aimed to examine the predictive role frailty on long‐term mortality in subjects with CHF. Materials methods assessed after 12‐year follow up 120 CHF 1139 without CHF, selected 1992, from random sample population Campania region Italy. Frailty was according ‘Frailty Staging System’. Results...
<i>Background:</i> Hearing impairment (HI) is a very common condition in elderly people and the epidemiology together with hearing-related problems still poorly investigated. Moreover, cognitive status may be impaired relation to hearing function. <i>Objective:</i> The goal of study was evaluate: (a) prevalence HI random sample aged 65 over (n = 1,750) living Campania, region southern Italy; (b) cross-sectional relationship between function also depressive...
OBJECTIVE: Congestive heart failure (CHF) is potentially preventable, and the identification of modifiable risk factors for cognitive impairment (CI) older persons a very important issue. We examined cross‐sectional relationship between CHF CI in an population. DESIGN: A survey. SETTING AND PARTICIPANTS: total 1339 subjects aged 65 were selected from electoral rolls Campania, region southern Italy. MEASUREMENTS: Sociodemographic characteristics recorded, as was presence cardiovascular...
We evaluated the outcome of spirometry quality control program SA.R.A. multicenter project, aim which is multidimensional assessment asthma and COPD in elderly ( ⩾ 65 yr). The factors determining this were also evaluated. was based on standardized procedures (ATS recommendations), performed by specifically trained certified personnel; a fully-computerized spirometer with customized software used for spirometry. A reference center made monthly controls. Overall, 638 cases 984 controls...
The purpose of this study was to assess whether different stages chronic obstructive pulmonary disease (COPD) severity defined according the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria correlate with meaningful differences in health status. A total 381 COPD patients, aged 73+/-6 yrs, were classified five GOLD stages. Disease-specific (St George Respiratory Questionnaire (SGRQ)) and generic indexes status measured all patients. Multivariate analysis covariance or...
Background Frailty is a dynamic age-related condition of increased vulnerability characterized by declines across multiple physiologic systems and associated with an risk death. We compared the predictive accuracy for one-month one-year all-cause mortality four frailty instruments in large population hospitalized older patients prospective multicentre cohort study. Methods Findings On 2033 aged ≥65 years from twenty Italian geriatric units, we calculated indexes derived Study Osteoporotic...
Multidimensional impairment of older patients may influence the clinical outcome diseases. The aim this study was to evaluate whether a Prognostic Index (MPI) based on comprehensive geriatric assessment predicts short-term mortality in with heart failure.In prospective 1-month follow-up, 376 aged 65 and diagnosis failure were enrolled. A standardized that included information functional (activities daily living instrumental activities living), cognitive (Short Portable Mental Status...
Objective The aim of this study was to investigate the cross-sectional relationship between arterial blood pressure and cognitive impairment in a group elderly subjects, controlling for such confounding variables as age, education, depression, drug use antihypertensive treatment. Design setting A survey Campania, region southern Italy. Subjects methods random sample 1339 subjects aged 65–95 years (mean 73.9 ± 6.2 years) selected from electoral rolls interviewed by trained physicians....
Aims We investigated whether exercise training could promote angiogenesis and improve blood perfusion left ventricular (LV) remodelling of the post-myocardial infarction (MI) failing heart.We also explored contribution ameliorated b-adrenergic receptor signalling function on overall improvement cardiac contractility reserve induced by exercise.Methods results Adult Wistar male rats were randomly assigned to one four experimental groups.Sham-operated post-MI heart failure (HF) housed under...
OBJECTIVES: To test the applicability and safety of a standardized diagnostic algorithm in geriatric departments to define prevalence different causes syncope older patients. DESIGN: Multicenter cross‐sectional observational study. SETTING: In‐hospital acute care outpatient clinics. PARTICIPANTS: Two hundred forty‐two patients (aged ≥65, mean±standard deviation =79±7, range 65–98) consecutively referred for evaluation transient loss consciousness any six clinical centers participating Of...
Antonelli-Incalzi, R; Corsonello, A; Pedone, C; Trojano, L; Acanfora, D; Spada, Izzo, O; Rengo, F.
Tumor growth requires neoangiogenesis. VEGF is the most potent proangiogenic factor. Dysregulation of hypoxia-inducible factor (HIF) or cytokine stimuli such as those involving chemokine receptor 4/stromal-derived cell 1 (CXCR4/SDF-1) axis are major cause ectopic overexpression in tumors. Although CXCR4/SDF-1 pathway well characterized, transcription factors executing effector function this signaling poorly understood. The multifunctional Yin Yang (YY1) protein highly expressed different...
Background: The role of ventricular rate response (VRr) on the incidence dementia in elderly subjects with cognitive impairment and atrial fibrillation (AF) is not known. Thus, we examined ability VRr to predict cognitively impaired without AF. Methods: A total 358 (MMSE <24) AF were stratified low/high (<50/>90) moderate (>50/<90 bpm) VRr. 10-year follow-up was performed. Results: Cognitively at end 135 (37.7%): 33 presence (75.0%) 102 (32.5%) absence (p < 0.001). Multivariate analysis...