A5021846516- Immunotherapy and Immune Responses
- Chemotherapy-induced cardiotoxicity and mitigation
- Peptidase Inhibition and Analysis
- Protease and Inhibitor Mechanisms
- HER2/EGFR in Cancer Research
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Chemokine receptors and signaling
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- Angiogenesis and VEGF in Cancer
- Cytokine Signaling Pathways and Interactions
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Cancer Treatment and Pharmacology
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- S100 Proteins and Annexins
- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Neuropeptides and Animal Physiology
- Radiopharmaceutical Chemistry and Applications
- Genetics and Neurodevelopmental Disorders
- Cancer, Stress, Anesthesia, and Immune Response
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"
2013-2023
Tumori Foundation
2006-2023
Cancer Institute (WIA)
2009-2018
Istituti di Ricovero e Cura a Carattere Scientifico
2013-2018
Naples Anesthesia & Physician Associates
2018
Fondazione IRCCS Istituto Nazionale dei Tumori
2014-2016
Istituto Pasteur
2013
University of Naples Federico II
2009-2013
Sapienza University of Rome
2013
University of Salerno
2013
Abstract Pentose phosphate pathway (PPP) is a major glucose metabolism pathway, which has fundamental role in cancer growth and metastasis. Even though PPP blockade been pointed out as very promising strategy against cancer, effective anti-PPP agents are not still available the clinical setting. Here we demonstrate that natural molecule polydatin inhibits glucose-6-phosphate dehydrogenase (G6PD), key enzyme of PPP. Polydatin blocks G6PD causing accumulation reactive oxygen species strong...
The CBX7 gene encodes a polycomb group protein that is known to be downregulated in many types of human cancers, although the role this carcinogenesis remains unclear. To shed light on issue, we generated mice null for Cbx7. Mouse embryonic fibroblasts derived from these had higher growth rate and reduced susceptibility senescence compared with their WT counterparts. This was associated upregulated expression multiple cell cycle components, including cyclin E, which play key lung humans....
Among the most important traditional medicinal fungi, Ganoderma lucidum has been used as a therapeutic agent for treatment of numerous diseases, including cancer, in Oriental countries. The aim this study is to investigate anti-inflammatory, anticancer and anti-metastatic activities extracts melanoma triple-negative breast cancer cells. were prepared by using common organic solvents; MDA-MB 231 B16-F10 cell lines adopted cellular models characterized viability, wound-healing assay...
Polymeric nanoparticles (PNPs) may efficiently deliver in vivo therapeutics to tumors when conjugated specific targeting agents. Gint4.T aptamer specifically recognizes platelet-derived growth factor receptor β and can cross the blood-brain barrier (BBB). We synthesized Gint4.T-conjugated PNPs able of high uptake into U87MG glioblastoma (GBM) cells with astonishing EC50 value (38 pM) loaded a PI3K-mTOR inhibitor. also demonstrated BBB passage tumor accumulation GBM orthotopic model.
Breast cancer is considered the most common for women worldwide and it now second leading cause of cancer-related deaths among females in world. Since breast highly resistant to chemotherapy, alternative anticancer strategies have been developed. In particular, many studies demonstrated that curcumin, a derivative turmeric, can be used as natural agent treatment some types by playing antiproliferative antioxidant effects. our study, we assessed antitumor activities curcumin ER-negative human...
Pancreatic cancer is a malignant neoplasm originating from transformed cells arising in tissues forming the pancreas. The best chemotherapeutic agent used to treat pancreatic gemcitabine. However, gemcitabine treatment associated with many side effects. Thus novel strategies involving less toxic agents for of are necessary. Curcumin one such that inhibits proliferation and angiogenesis wide variety tumor cells, through modulation cell signalling pathways. In this study, we investigated...
Abstract Background Inefficient T-cell access to the tumor microenvironment (TME) is among causes of immune-resistance. Previous evidence demonstrated that targeting CXCR4 improves anti-PD-1/PD-L1 efficacy reshaping TME. To evaluate role newly developed antagonists (PCT/IB2011/000120/ EP2528936B1/US2013/0079292A1) in potentiating anti-PD-1 two syngeneic murine models, MC38 colon cancer and B16 melanoma-human CXCR4-transduced, were employed. Methods Mice subcutaneously injected with (1 × 10 6...
Congenital hypothyroidism with thyroid dysgenesis (TD) is a frequent human condition characterized by elevated levels of TSH in response to reduced hormone levels. genetically heterogeneous disease. In the majority cases studied, no causative mutations have been identified and very often disease does not show Mendelian transmission. However, approximately 5% cases, it can be consequence genes encoding receptor or transcription factors TITF1, FOXE1, PAX8. We report here that mouse models,...
BAG3, a member of the BAG family heat shock protein (HSP) 70 cochaperones, is expressed in response to stressful stimuli number normal cell types and constitutively variety tumors, including pancreas carcinomas, lymphocytic myeloblastic leukemias, thyroid carcinomas. Down-regulation BAG3 results death, but underlying molecular mechanisms are still elusive. Here, we investigated mechanism BAG3-dependent survival human osteosarcoma (SAOS-2) melanoma (M14) cells. We show that bag3...
Tumor growth requires neoangiogenesis. VEGF is the most potent proangiogenic factor. Dysregulation of hypoxia-inducible factor (HIF) or cytokine stimuli such as those involving chemokine receptor 4/stromal-derived cell 1 (CXCR4/SDF-1) axis are major cause ectopic overexpression in tumors. Although CXCR4/SDF-1 pathway well characterized, transcription factors executing effector function this signaling poorly understood. The multifunctional Yin Yang (YY1) protein highly expressed different...
The metastatic process is the most serious cause of cancer death. Norepinephrine, secreted in chronic stress conditions, stimulates motility breast and colon cells through β-adrenergic receptor. On these bases, we examined its possible role metastasis formation development vitro vivo. Treatments with norepinephrine (β2-adrenoreceptor agonist) mice xenografted human DU145 prostate increased potential cells. Specifically, showed that treatment induced a significant increase migratory activity...
The incidence and death rate of pancreatic ductal adenocarcinoma (PDAC) have increased in recent years, therefore the identification novel targets for treatment is extremely important. Interactions between cancer stromal cells are critically involved tumour formation development metastasis. Here we report that PDAC secrete BAG3, which binds activates macrophages, inducing their activation secretion supporting factors. We also identify IFITM-2 as a BAG3 receptor show it signals through PI3K...
Morphine is considered a highly potent analgesic agent used to relieve suffering of patients with cancer. Several in vitro and vivo studies showed that morphine also modulates angiogenesis regulates tumour cell growth. Unfortunately, the results obtained by these are still contradictory. In order better dissect role cancer growth we performed on ER-negative human breast carcinoma cells, MDA.MB231 heterotopic mouse model triple negative cancer, TNBC. We demonstrated enhanced proliferation...
The CXCR4/CXCL12 axis plays a role in cancer metastases, stem cell mobilization and chemosensitization. Proof of concept for efficient CXCR4 inhibition has been demonstrated prior to autologous transplantation hematological malignancies. Nevertheless inhibitors suitable prolonged use as required anticancer therapy are not available. To develop new antagonists rational, ligand-based approach was taken, distinct from the more commonly used development strategy. A three amino acid motif...