A5060282315- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Hedgehog Signaling Pathway Studies
- RNA Interference and Gene Delivery
- Cancer Genomics and Diagnostics
- Advanced biosensing and bioanalysis techniques
- Epigenetics and DNA Methylation
- Cancer Cells and Metastasis
- Extracellular vesicles in disease
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Fungal Biology and Applications
- Nigella sativa pharmacological applications
- Microbial Inactivation Methods
- Icing and De-icing Technologies
- RNA modifications and cancer
- TGF-β signaling in diseases
- Mitochondrial Function and Pathology
- Chemotherapy-induced organ toxicity mitigation
- Neuroblastoma Research and Treatments
- Autophagy in Disease and Therapy
- Microfluidic and Bio-sensing Technologies
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
University of Campania "Luigi Vanvitelli"
2019-2024
Biogem
2023-2024
Zero to Three
2021
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"
2016-2017
Cancer Institute (WIA)
2016
Among the most important traditional medicinal fungi, Ganoderma lucidum has been used as a therapeutic agent for treatment of numerous diseases, including cancer, in Oriental countries. The aim this study is to investigate anti-inflammatory, anticancer and anti-metastatic activities extracts melanoma triple-negative breast cancer cells. were prepared by using common organic solvents; MDA-MB 231 B16-F10 cell lines adopted cellular models characterized viability, wound-healing assay...
Abstract Background Exosomes are nanosized vesicles released from all cells into surrounding biofluids, including cancer cells, and represent a very promising direction in terms of minimally invasive approaches to early disease detection. They carry tumor-specific biological contents such as DNA, RNA, proteins, lipids, sugars, well surface molecules that able pinpoint the cellular source. By above criteria, exosomes may be stratified according presence tissue disease-specific signatures and,...
Laryngeal cancer (LCa), a neoplasm of the head and neck region, is leading cause death worldwide. Surgical intervention remains mainstay LCa treatment, but crucial point represented by possible nodal involvement. Therefore, it urgently needed to develop biomarkers therapeutic tools able drive treatment approaches for LCa. In this study, we investigated deregulated microRNAs (miRNAs) in tissues from patients with either lymph node metastases (N+) or not (N−). miRNA expression profiling was...
MicroRNAs (miRNAs) are involved in post-transcriptional gene expression regulation and mechanisms of cancer growth metastases. In this light, miRNAs could be promising therapeutic targets biomarkers clinical practice. Therefore, we investigated if specific their target genes contribute to laryngeal squamous cell carcinoma (LSCC) development. We found a significant decrease miR-449a LSCC patients with nodal metastases (63.3%) compared without involvement (44%). The AmpliSeq Transcriptome...
Pancreatic ductal adenocarcinoma (PDAC), a neoplasm of the gastrointestinal tract, is most common pancreatic malignancy (90%) and fourth highest cause cancer mortality worldwide. Surgery intervention currently only strategy able to offer an advantage in terms overall survival, but prognosis remains poor even for operated patients. Therefore, development robust biomarkers early diagnosis prognostic stratification clinical practice urgently needed. In this work, we investigated deregulated...
The growing understanding of cancer biology and the establishment new treatment modalities has not yielded expected results in terms survival for Laryngeal Squamous Cell Cancer (LSCC). Early diagnosis, as well prompt identification patients with high risk relapse would ensure greater chance therapeutic success. However, this goal remains a challenge due to absence specific biomarkers neoplasm.
Laryngeal neuroendocrine carcinomas (LNECs) are rare and highly heterogeneous malignancies presenting a wide range of pathological clinical manifestations. Herein, we retrospectively characterize ten patients diagnosticated with LNEC, five which were defined as well-moderately differentiated carcinomas, that poorly according to the latest WHO classification. Clinical features analyzed compared between two subgroups together microRNA study evidenced peculiar signature likely related larynx...
Abstract Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human malignancies: novel therapeutic approaches beyond conventional chemotherapy are still lacking and prognosis remains poor, even for resectable patients (pts). Furthermore, there an almost complete absence validated predictive factors. Consequently, robust biomarkers early diagnosis prognostic stratification urgently needed in clinical practice, especially context neoadjuvant adjuvant settings. In last...