A5003063866- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Cancer Studies
- Vestibular and auditory disorders
- Ear and Head Tumors
- Cancer-related molecular mechanisms research
- Ear Surgery and Otitis Media
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer Diagnosis and Treatment
- Hearing, Cochlea, Tinnitus, Genetics
- Head and Neck Surgical Oncology
- Head and Neck Anomalies
- Sinusitis and nasal conditions
- Facial Nerve Paralysis Treatment and Research
- Oral and Maxillofacial Pathology
- Nasal Surgery and Airway Studies
- Voice and Speech Disorders
- Infectious Diseases and Tuberculosis
- Mycobacterium research and diagnosis
- Allergic Rhinitis and Sensitization
- Cancer Immunotherapy and Biomarkers
- Hearing Loss and Rehabilitation
- Olfactory and Sensory Function Studies
- Ophthalmology and Eye Disorders
- Meningioma and schwannoma management
Ospedale Antonio Cardarelli
2013-2025
Fatebenefratelli Hospital
2017-2024
University of Naples Federico II
2005-2017
Federico II University Hospital
2006-2017
Background: There is growing evidence of otoneurological involvement SARS-CoV-2, such as tinnitus and balance disorders smell taste disorders, but HL in COVID-19 patients has still been marginally studied. Investigating the role SARS-CoV-2 an aetiological factor Sudden Sensorineural Hearing Loss (SSNHL) may offer opportunity to address treatment strategies maximize clinical recovery avoid side effects. Methods results: For this purpose, we will present case studies five who experienced SSNHL...
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a chronic type 2 inflammatory disease characterized by olfactory impairment (OI) as one of the most troublesome symptoms. Currently, biologics represent new option in treatment uncontrolled CRSwNP. This retrospective real-life observational study involving adult patients affected severe At baseline, and 3 6 months after Dupilumab add on to intranasal steroids (INS), underwent 22-item Sinonasal Outcome Test (SNOT-22), endoscopy, Visual...
Abstract Background Exosomes are nanosized vesicles released from all cells into surrounding biofluids, including cancer cells, and represent a very promising direction in terms of minimally invasive approaches to early disease detection. They carry tumor-specific biological contents such as DNA, RNA, proteins, lipids, sugars, well surface molecules that able pinpoint the cellular source. By above criteria, exosomes may be stratified according presence tissue disease-specific signatures and,...
Laryngeal cancer (LCa), a neoplasm of the head and neck region, is leading cause death worldwide. Surgical intervention remains mainstay LCa treatment, but crucial point represented by possible nodal involvement. Therefore, it urgently needed to develop biomarkers therapeutic tools able drive treatment approaches for LCa. In this study, we investigated deregulated microRNAs (miRNAs) in tissues from patients with either lymph node metastases (N+) or not (N−). miRNA expression profiling was...
The diffusion of laryngeal cancer cells in the perineural space is a parameter associated with negative prognosis, high loco-regional recurrence and low disease-free survival rates. spread tumor on sheath highlights histopathological clinically aggressive behavior this type tumor, which may extend proximally or distally nerve for >10 cm. Therefore, surgical resection margin generally insufficient to treat patients presenting invasion (PNI) surgery alone. In PNI, minor nerves are frequently...
Temporal bone fractures are a common lesion of the base skull. The diagnosis and management temporal require multidisciplinary approach. Variable clinical presentations may arise from such fractures, ranging an asymptomatic course to very serious consequences. aim this study was report our experience with series patients propose diagnostic/therapeutic algorithm. This enrolled 141 patients, 96 (68.1%) males 45 (31.9%) females, in age 20 60 (average age: 39 ± 4.1 years), who were referred...
The aim of this study is to identify certain parapharyngeal space tumours with specific characteristics that can be treated successfully through an endoscopically assisted transoral approach (EATA).Nine patients PPS underwent surgery EATA between 2003 and 2021. All clinical examination fibrolaryngoscopy. Preoperative CT and/or MRI was performed on all patients.All the were approach. Histological revealed five pleomorphic adenomas, two schwannomas, one ectopic thyroid gland lipoma. only...
Background. The acinic cell carcinoma (AciCC) of the parotid gland is a rare tumor with an indolent behavior; however, subgroup this presents aggressive behavior tendency to recur. aim multicenter study was identify and stratify those patients AciCC at high risk recurrence. Methods. A retrospective carried out involving 77 treated surgery between January 2000 September 2022, in different Italian referral centers. Data about characteristics its recurrence were collected. histological...
MicroRNAs (miRNAs) are involved in post-transcriptional gene expression regulation and mechanisms of cancer growth metastases. In this light, miRNAs could be promising therapeutic targets biomarkers clinical practice. Therefore, we investigated if specific their target genes contribute to laryngeal squamous cell carcinoma (LSCC) development. We found a significant decrease miR-449a LSCC patients with nodal metastases (63.3%) compared without involvement (44%). The AmpliSeq Transcriptome...
Abstract Background The purpose of this multicenter study was to retrospectively investigate the prognostic significance tumor microenvironment, in relation survival a large cohort patients with laryngeal squamous cell carcinoma (LSCC), using method proposed by International TILs Working Group breast cancer. Methods All consecutive biopsy‐proven LSCC who underwent total laryngectomy (TL) between January 2014 and 2023 were included study. A retrospective review medical records including...
The growing understanding of cancer biology and the establishment new treatment modalities has not yielded expected results in terms survival for Laryngeal Squamous Cell Cancer (LSCC). Early diagnosis, as well prompt identification patients with high risk relapse would ensure greater chance therapeutic success. However, this goal remains a challenge due to absence specific biomarkers neoplasm.
Septoplasty is one of the most frequent surgical procedures performed by otolaryngologists. Despite successful correction, manypatients are not satisfied with their outcomes. So far, in clinical practice there no consensus opinion about reliability objectivemeasurements nasal patency and correlation between objective measurements subjective symptoms. This studyaims to assess reasons for patient dissatisfaction after septoplasty optimise pre-operative diagnostic management predict...
Sudden Sensorineural Hearing Loss (SSNHL) is a relatively rare symptom after immunisation from commonly used vaccines such as rabies, hepatitis B, measles and H1N1 it could be an occasional of COVID-19, even in mild manifestations the disease. We describe case 57-year-old patient that reported SSNHL tinnitus his right ear 2 days inoculation Oxford-AstraZeneca (VAXZEVRIA) Covid-19 vaccine. The almost fully recovered therapy was referred to long term follow-up program. current report...
Abstract Objectives To analyze the demographic data, surgical and adjuvant treatment data survival outcomes in adult patients affected by acinic cell carcinoma of parotid gland (AciCC). Methods A retrospective multicenter analysis treated for AciCC from 2000 to 2021 was performed. Exclusion criteria were pediatric (0–18 years) patients, absence follow-up with secondary metastatic disease gland. Multivariable logistic regression used determine factors associated survival. Results The study...
Advanced head and neck squamous cell cancer (HNSCC) is currently treated with taxane-based chemotherapy. We have previously shown that docetaxel (DTX) induces a ras-dependent survival signal can be antagonized by farnesyl transferase inhibitors (FTI) such as tipifarnib (TIP). Here we show the synergistic TIP/DTX combination determines apoptotic conditions but, at same time, it modulates expression of components multichaperone complex is, in turn, involved regulation stability members...