A5029913536- Nasal Surgery and Airway Studies
- Sinusitis and nasal conditions
- Voice and Speech Disorders
- Olfactory and Sensory Function Studies
- Ear Surgery and Otitis Media
- Ear and Head Tumors
- Salivary Gland Tumors Diagnosis and Treatment
- Teratomas and Epidermoid Cysts
- Allergic Rhinitis and Sensitization
- Tumors and Oncological Cases
- Advanced Chemical Sensor Technologies
- Biochemical Analysis and Sensing Techniques
- Tracheal and airway disorders
- Head and Neck Surgical Oncology
- Oral and Maxillofacial Pathology
- Head and Neck Anomalies
- Facial Nerve Paralysis Treatment and Research
- Vascular Malformations and Hemangiomas
- Soft tissue tumor case studies
- Cystic Fibrosis Research Advances
- Bone Tumor Diagnosis and Treatments
- Obstructive Sleep Apnea Research
- Vestibular and auditory disorders
- Head and Neck Cancer Studies
- Hearing, Cochlea, Tinnitus, Genetics
University of Naples Federico II
2005-2021
Federico II University Hospital
2012-2018
Fatebenefratelli Hospital
2017
Azienda Ospedaliero Universitario Mater Domini
2000
University of Reggio Calabria
1992
Background Functional endoscopic sinus surgery (FESS) has become the treatment of choice for patients with medically resistant chronic rhinosinusitis (CRS) and nasal polyps. Despite consolidated use different treatments, postoperative period is often very painful uncomfortable, especially during first month. Although evidence on effectiveness sodium hyaluronate (SH) care following FESS available, data quality life (QoL) from patients’ perspective are still lacking. This study aimed to...
Background Right insular cortex is involved in taste discrimination, but its functional organization still poorly known. In general, sensory cortices represent the spatial prevalence of relevant features for each modality (visual, auditory, somatosensory) an ordered way across cortical space. Following this analogy, we hypothesized that primary organized similar response to six tastes with known receptorial mechanisms (sweet, bitter, sour, salt, umami, CO2). Design Ten normal subjects were...
Among the predisposing factors implicated in immune response to airway bacterial infections, genetic variations of bitter taste receptor TAS2R38, which is expressed cilia human sinonasal epithelial cells, seem be associated with susceptibility chronic rhinosinusitis (CRS) and vitro biofilm formation. Polymorphisms TAS2R38 generate two common haplotypes: nonfunctional AVI (Alanine, Valine, Isoleucine) functional PAV (Proline, Alanine, Valine) alleles, latter protecting against gram-negative...
Diffusion weighted imaging (DWI) has been proven to be valuable in the diagnosis of middle ear cholesteatoma. The aims our study were evaluate advantage multi-shot turbo spin echo (MSh TSE) DWI compared single-shot echo-planar (SSh EPI) for cholesteatoma.Thirty-two patients with clinical suspicion unilateral cholesteatoma underwent preoperative MRI (1.5T) SSh EPI and MSh TSE. Images separately analyzed by 4 readers different expertise confirm presence Sensitivity, specificity, diagnostic...
Background Cystic fibrosis (CF) is a multisystem disease that involves the upper airways with chronic rhinosinusitis (CRS) causing nasal congestion, rhinorrhea, mouth breathing, facial pain, and olfactory dysfunction. Twelve percent to 71% of CF patients report smelling alterations an impact on nutrition quality life. Objectives The goal was study olfaction performance in CRS worsens Methods A total 121 subjects were enrolled this study. Seventy-one had underwent ear, nose, throat evaluation...
Only a few reports in the literature have described use of specific instruments for assessing quality life adolescents and young adults with cleft lip palate (CLP). This condition markedly affects their lifestyle, even after surgical treatment. In present study, we aimed to develop quality-of-life assessment tool specifically designed such patients CLP. Our multidisciplinary team created questionnaire focused on physical, psychological, social satisfaction CLP, which was adapted from 3...
The diffusion of laryngeal cancer cells in the perineural space is a parameter associated with negative prognosis, high loco-regional recurrence and low disease-free survival rates. spread tumor on sheath highlights histopathological clinically aggressive behavior this type tumor, which may extend proximally or distally nerve for >10 cm. Therefore, surgical resection margin generally insufficient to treat patients presenting invasion (PNI) surgery alone. In PNI, minor nerves are frequently...
La fibrosi cistica (FC) è una malattia autosomica recessiva causata da mutazioni nel gene CFTR (Cystic Fibrosis Transmembrane conductance Regulator). Finora sono state descritte circa 2000 mutazioni, ma per la maggior parte di esse difficile definirne leffetto senza complesse procedure in vitro. Abbiamo effettuato il campionamento (mediante brushing), cultura e lanalisi cellule epiteliali nasali umane (HNEC) utilizzando serie tecniche che possono aiutare a testare delle CFTR. eseguito 50...
Extramedullary plasmacytoma is a rare neoplasm characterized by monoclonal proliferation of plasma cells outside bone marrow. It accounts for 4% all non-epithelial sinonasal tumors. According to the literature, radiotherapy standard therapy extramedullary plasmacytoma. However, conversion rate multiple myeloma reported be between 11 and 33% over 10 years. The highest risk during first 2 years after diagnosis, but has been noted up 15 diagnosis. Once complete, less than 10% patients will...
Septoplasty is one of the most frequent surgical procedures performed by otolaryngologists. Despite successful correction, manypatients are not satisfied with their outcomes. So far, in clinical practice there no consensus opinion about reliability objectivemeasurements nasal patency and correlation between objective measurements subjective symptoms. This studyaims to assess reasons for patient dissatisfaction after septoplasty optimise pre-operative diagnostic management predict...
Available medical treatments for chronic rhinosinusitis (CRS) with nasal polyposis (CRSwNP) comprise systemic and topical therapies. Although corticosteroids are effective in the treatment of CRS, they not completely devoid adverse effects. Thus, care has to be taken when long-term prescribed. There is recent evidence that sodium hyaluronate (SH), major component many extracellular matrices, promotes tissue healing, including activation moderation inflammatory responses, cell proliferation,...
Objectives. Magnetic resonance imaging (MRI) and in particular diffusion-weighted (DWI) have been broadly proven to be the reference method discriminate between cholesteatoma noncholesteatomatous middle ear lesions, especially when high tissue specificity is required. The aim of this study define a range apparent diffusion coefficient (ADC) values within which diagnosis almost certain. Methods. was retrospectively conducted on cohort 124 patients. All patients underwent first- or second-look...
Developments in surgical technique and, more importantly, the use of increasingly sophisticated biocompatible prostheses have meant that good results can be achieved for otosclerosis sufferers terms restored hearing and very little postsurgical discomfort. We set out to assess whether diameter used stapedotomy (platinum piston/polytetrafluoroethylene, i.e. Teflon) has any effect on outcome. Two groups otosclerotic patients were selected, these underwent surgery during second phase disease. A...
We have analyzed the preoperative diagnosis of cholesteatoma through use diffusion-weighted intensity magnetic resonance (DWI-MR) in 16 consecutive patients suffering from chronic otitis media with clinical and radiological (by computed tomography) suspicion cholesteatoma. In particular, we compared data intraoperative ones, verifying correspondence (in terms sensitivity, specificity, positive predictive value, negative value diagnostic accuracy) between what is reported by DWI-MR actually...
To evaluate the effectiveness of crenotherapy on olfactory performance elderly patients with chronic rhinosinusitis (CRS).A longitudinal case-control study a cohort affected by CRS and dysfunction assessed Sniffin' Sticks (Burghart Medical Technology, Wedel, Germany) (SS) test.One hundred thirty-seven subjects were divided into two groups. The investigational arm (n = 69) underwent hyperthermal water, rich in mineral salts, control group 68) NaCl 0.9% both for 12 days. At baseline at 1 6...