A5038934034- Head and Neck Cancer Studies
- Tracheal and airway disorders
- Salivary Gland Tumors Diagnosis and Treatment
- Ear and Head Tumors
- Voice and Speech Disorders
- Tumors and Oncological Cases
- Ear Surgery and Otitis Media
- Teratomas and Epidermoid Cysts
- Head and Neck Anomalies
- Nasal Surgery and Airway Studies
- Dysphagia Assessment and Management
- Obstructive Sleep Apnea Research
- Oral and Maxillofacial Pathology
- Cancer Diagnosis and Treatment
- Asthma and respiratory diseases
- Oropharyngeal Anatomy and Pathologies
- Neuroscience of respiration and sleep
- Allergic Rhinitis and Sensitization
- Sarcoma Diagnosis and Treatment
- MicroRNA in disease regulation
- Facial Nerve Paralysis Treatment and Research
- Congenital Ear and Nasal Anomalies
- Meningioma and schwannoma management
- Vestibular and auditory disorders
- Neurofibromatosis and Schwannoma Cases
University of Naples Federico II
2010-2024
Federico II University Hospital
2004-2021
Ospedale Antonio Cardarelli
2020
Eni (Italy)
2005
University of Campania "Luigi Vanvitelli"
2001
Laryngeal cancer (LCa), a neoplasm of the head and neck region, is leading cause death worldwide. Surgical intervention remains mainstay LCa treatment, but crucial point represented by possible nodal involvement. Therefore, it urgently needed to develop biomarkers therapeutic tools able drive treatment approaches for LCa. In this study, we investigated deregulated microRNAs (miRNAs) in tissues from patients with either lymph node metastases (N+) or not (N−). miRNA expression profiling was...
The diffusion of laryngeal cancer cells in the perineural space is a parameter associated with negative prognosis, high loco-regional recurrence and low disease-free survival rates. spread tumor on sheath highlights histopathological clinically aggressive behavior this type tumor, which may extend proximally or distally nerve for >10 cm. Therefore, surgical resection margin generally insufficient to treat patients presenting invasion (PNI) surgery alone. In PNI, minor nerves are frequently...
A retrospective study is presented to correlate the inter-judge consistency for different psycho-perceptual parameters of recently proposed Impression Noise Fluency Voicing (INFVo) perceptual rating scale substitution voices, and vocal function as perceived by patient.The Voice-Related Quality Life (V-RQoL) Self Evaluation Communication Experiences After Laryngectomy (SECEL)-a self-evaluation questionnaire communicative experience after laryngectomy surgery-were administered 89 total...
MicroRNAs (miRNAs) are involved in post-transcriptional gene expression regulation and mechanisms of cancer growth metastases. In this light, miRNAs could be promising therapeutic targets biomarkers clinical practice. Therefore, we investigated if specific their target genes contribute to laryngeal squamous cell carcinoma (LSCC) development. We found a significant decrease miR-449a LSCC patients with nodal metastases (63.3%) compared without involvement (44%). The AmpliSeq Transcriptome...
The growing understanding of cancer biology and the establishment new treatment modalities has not yielded expected results in terms survival for Laryngeal Squamous Cell Cancer (LSCC). Early diagnosis, as well prompt identification patients with high risk relapse would ensure greater chance therapeutic success. However, this goal remains a challenge due to absence specific biomarkers neoplasm.
Developments in surgical technique and, more importantly, the use of increasingly sophisticated biocompatible prostheses have meant that good results can be achieved for otosclerosis sufferers terms restored hearing and very little postsurgical discomfort. We set out to assess whether diameter used stapedotomy (platinum piston/polytetrafluoroethylene, i.e. Teflon) has any effect on outcome. Two groups otosclerotic patients were selected, these underwent surgery during second phase disease. A...
Keratin 5 (K5) is present in the basal layer of a stratified squamous keratinized and non‑keratinized epithelium. K5 K14 have been demonstrated mucosa tumors oral cavity, oropharynx, hypopharynx larynx, mitotic active cells The aim study was to assess expression squamocellular carcinoma with various localizations head neck. A total 13 biopsy fragments were included from patients diagnosed larynx area (n=2), pharynx hard palate (n=1), tongue submandibular lip gingival sulcus nasal pyramid...
Basaloid squamous cell carcinoma (BSCC) is a rare, aggressive and distinct variant of (SCC) the upper respiratory digestive tract. We have evaluated disease specific survival (DSS) overall (OS) through Kaplan-Meier method mortality risk univariate statistical analysis Cox in 42 cases BSCC other laryngeal SCC (LSCC) matched for both age sex. demonstrated that more tumor than LSCC as associated to higher nodal recurrence pathology (5 vs 2 patients, risk, OR 2.7), reduced (median 34 40 months,...
Objective: The objective of our study was to compare experience intracapsular tonsillotomy performed with the help a microdebrider usually used for adenoidectomy results obtained from extracapsular surgery through dissection and in cases people affected OSAS, linked adeno-tonsil hypertrophy, observed treated last 5 years. Methods: 3127 children adenotonsillar hyperplasia OSAS-related clinical symptoms (aged between 3 12 years) underwent tonsillectomy and/or adenoidectomy. A total 1069...
Adenoid cystic carcinoma (ACC) is a relatively rare tumor that accounts for <1% of all head and neck malignancies. Laryngeal localization ACC, which most commonly hypoglottic, rare, occurring in 0.07-0.25% laryngeal tumors. ACC characterized as slow-growing with high recurrence rate, often causes dyspnea hoarseness. exhibits propensity perineural invasion thus, patients may experience pain late symptom the disease. Distant metastasis occurs 35-50% cases lungs are common site metastasis....
Lipoma is a common benign tumor affecting the soft tissues arising in every location where fat normally present. About 15% of lipomas occur head and neck region. The lipoma parotid gland rare entity, comprising 0.6% - 4.4% all tumors. etiology remains unclear. case described superficial lobe 46-year-old male.
Background: Given that the temporal bone is one of most complex regions human body, cadaveric dissection this anatomical area represents first necessary step for learning and training young oto-surgeon in order to perform middle ear surgery, which includes management inflammatory pathology, hearing rehabilitation, also cognitive decline prevention surgery. The primary objective study was identify common mistakes critical passages during initial steps dissection, specifically cortical...
Background: Permanent tracheostomy because of total laryngectomy surgery entails great conse-quences for the patient regarding respiratory physiopathology such as filtering, humidifying, and heating function air by nose is lost. The use special stomal filters can determine adequate protection trachea-broncho-pulmonary system with a reduction in pathologies. In fact, most cases laryngectomee patients are first cigarette smokers who this reason already have also diseases chronic obstructive...