A5032860019- Lung Cancer Diagnosis and Treatment
- Tracheal and airway disorders
- Lung Cancer Treatments and Mutations
- Ear Surgery and Otitis Media
- Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Voice and Speech Disorders
- Obstructive Sleep Apnea Research
- Peripheral Artery Disease Management
- Ear and Head Tumors
- Otolaryngology and Infectious Diseases
- Metastasis and carcinoma case studies
- Lung Cancer Research Studies
- Head and Neck Anomalies
- Dysphagia Assessment and Management
- Cardiac pacing and defibrillation studies
- Infectious Aortic and Vascular Conditions
- Vestibular and auditory disorders
- Multiple and Secondary Primary Cancers
- Cardiac electrophysiology and arrhythmias
- Cancer-related molecular mechanisms research
- Airway Management and Intubation Techniques
- Venous Thromboembolism Diagnosis and Management
University of Campania "Luigi Vanvitelli"
2018-2025
Ospedale Antonio Cardarelli
2021-2024
Nuovo Ospedale San Giovanni di Dio
2018
Federico II University Hospital
2000-2013
University of Naples Federico II
2001-2006
University of Genoa
1989-2004
Tokyo University of Science
2001
Tokyo National Hospital
2001
The University of Texas MD Anderson Cancer Center
1999
Istituto Nazionale di Fisica Nucleare, Sezione di Napoli
1996
The aim of the study was to assess effectiveness CO(2) laser endoscopic surgery in treatment glottic carcinoma limited true vocal cords or involving adjacent regions.Seven hundred nineteen patients (687 men and 32 women; mean age, 60.4 years; range, 33-86 years) with (432 T1N0M0, 236 T2N0M0, 51 T3N0M0) underwent (mean follow-up, 5 2-17 years). Statistical comparison carried out Wilcoxon test, considering p < .05 minimum significance value.Overall actuarial survival, adjusted percentage no...
Abstract This study presents data suggesting that both human mesothelioma (cell lines and biopsies) normal mesothelial cells express receptors for acetylcholine stimulation of these by nicotine prompted cell growth via activation nicotinic cholinergic receptors. Thus, demonstrate that: (a) biopsies as well pleural functionally α-7 acethlycholine receptors, evaluated α-bungarotoxin-FITC binding, receptor binding assay, Western blot, reverse transcription-PCR; (b) choline acetyltransferase...
Abstract Background Exosomes are nanosized vesicles released from all cells into surrounding biofluids, including cancer cells, and represent a very promising direction in terms of minimally invasive approaches to early disease detection. They carry tumor-specific biological contents such as DNA, RNA, proteins, lipids, sugars, well surface molecules that able pinpoint the cellular source. By above criteria, exosomes may be stratified according presence tissue disease-specific signatures and,...
This research aims at reporting the results of endoscopic treatment glottic carcinomas by CO2 laser. The cases cited concern 516 patients with T1-T2-T3 carcinomas. have been divided into 5 groups: a) T1a: 194 monolateral carcinoma involving true vocal cord who underwent simple cordectomy; b) T2a: 104 cordal ventricle and false cord; c) T1b: 127 or bilateral anterior commissure; d) these T2b: 54 commissure extending to hypoglottic supraglottic region; in a extended cordectomy was performed;...
Background: This multicenter, prospective study evaluated the determinants of zero-fluoroscopy (ZFL) ablation supraventricular tachycardias. Methods and Results: Four hundred thirty patients (215 male, 55.4±22.1 years) with indication to electrophysiological or tachycardias were enrolled. All participating physicians agreed follow as low reasonably achievable policy. A procedure was defined ZFL when no fluoroscopy used. The total time inversely correlated number procedures previously...
Laryngeal cancer (LCa), a neoplasm of the head and neck region, is leading cause death worldwide. Surgical intervention remains mainstay LCa treatment, but crucial point represented by possible nodal involvement. Therefore, it urgently needed to develop biomarkers therapeutic tools able drive treatment approaches for LCa. In this study, we investigated deregulated microRNAs (miRNAs) in tissues from patients with either lymph node metastases (N+) or not (N−). miRNA expression profiling was...
Abstract Acinar cells of human major salivary glands, fixed and processed for electron microscopy under identical conditions, exhibit secretory granules endowed with distinctive ultrastructural features.
The growing understanding of cancer biology and the establishment new treatment modalities has not yielded expected results in terms survival for Laryngeal Squamous Cell Cancer (LSCC). Early diagnosis, as well prompt identification patients with high risk relapse would ensure greater chance therapeutic success. However, this goal remains a challenge due to absence specific biomarkers neoplasm.
Several guidelines on adeno-tonsillar disease have been proposed in recent years and some discrepancies relation both to clinical manifestations indications for surgical treatment emerged. The aim of the study was verify what influence (adeno)-tonsillectomy had behaviour ENT specialists Italy. Our is a retrospective multi-centre case series with chart review.The survey involved 14,770 children, aged between ages 2 11, who undergone surgery 2002 2008 fourteen Italian tertiary secondary...
The aim of this study is to identify certain parapharyngeal space tumours with specific characteristics that can be treated successfully through an endoscopically assisted transoral approach (EATA).Nine patients PPS underwent surgery EATA between 2003 and 2021. All clinical examination fibrolaryngoscopy. Preoperative CT and/or MRI was performed on all patients.All the were approach. Histological revealed five pleomorphic adenomas, two schwannomas, one ectopic thyroid gland lipoma. only...
Occult cervical lymph node metastases may often be associated with cancers of the supraglottic larynx. The aims this investigation were: (1) to determine incidence occult in patients cancer larynx; (2) assess whether presence such was related extent primary tumor (T) and its grading (G); (3) discuss which therapeutic approach should followed treating clinically metastases. Our included 97 who underwent horizontal laryngectomy elective dissection. series considered 27%. Based on preoperative...
Subcutaneous implantable cardioverter defibrillators (S-ICDs) avoid complications secondary to transvenous leads, but inappropriate shocks (ISs) are frequent. Furthermore, IS data from patients with Brugada syndrome (BrS) an S-ICD scarce.We aimed establish the frequency and predictors of in this population.We analyzed clinical electrocardiographic characteristics, automated screening test data, device programming, occurrence adult BrS S-ICD.Thirty-nine were enrolled (69% male, mean age at...
Objective: The objective of our study was to compare experience intracapsular tonsillotomy performed with the help a microdebrider usually used for adenoidectomy results obtained from extracapsular surgery through dissection and in cases people affected OSAS, linked adeno-tonsil hypertrophy, observed treated last 5 years. Methods: 3127 children adenotonsillar hyperplasia OSAS-related clinical symptoms (aged between 3 12 years) underwent tonsillectomy and/or adenoidectomy. A total 1069...
Background: Given that the temporal bone is one of most complex regions human body, cadaveric dissection this anatomical area represents first necessary step for learning and training young oto-surgeon in order to perform middle ear surgery, which includes management inflammatory pathology, hearing rehabilitation, also cognitive decline prevention surgery. The primary objective study was identify common mistakes critical passages during initial steps dissection, specifically cortical...
Background: Descending necrotizing mediastinitis (DNM) is a life-threatening condition, generally caused by downward dissemination of oropharyngeal infections through cervical fascial planes. Mediastinal drainage conventionally achieved thoracotomy, but Video-Assisted Thoracoscopic Surgery (VATS) approach gaining interest due to the reduced invasiveness procedure. We aimed evaluate effectiveness VATS treatment in patients with DNM. Methods: conducted retrospective multicenter study including...
Background: Permanent tracheostomy because of total laryngectomy surgery entails great conse-quences for the patient regarding respiratory physiopathology such as filtering, humidifying, and heating function air by nose is lost. The use special stomal filters can determine adequate protection trachea-broncho-pulmonary system with a reduction in pathologies. In fact, most cases laryngectomee patients are first cigarette smokers who this reason already have also diseases chronic obstructive...