A5025167141- Cholinesterase and Neurodegenerative Diseases
- Environmental Toxicology and Ecotoxicology
- Nicotinic Acetylcholine Receptors Study
- Marine Biology and Environmental Chemistry
- Pesticide Exposure and Toxicity
- Photoreceptor and optogenetics research
- Nanoparticles: synthesis and applications
- Cancer-related Molecular Pathways
- Computational Drug Discovery Methods
- Toxic Organic Pollutants Impact
- Neuroendocrine regulation and behavior
- Microplastics and Plastic Pollution
- Neurobiology and Insect Physiology Research
- Chemical synthesis and alkaloids
- Marine and coastal plant biology
- Reproductive biology and impacts on aquatic species
- Aquaculture Nutrition and Growth
- Pesticide and Herbicide Environmental Studies
- Hepatitis B Virus Studies
- Marine Invertebrate Physiology and Ecology
- Cephalopods and Marine Biology
- Fish Ecology and Management Studies
- Pluripotent Stem Cells Research
- Sperm and Testicular Function
- Marine Sponges and Natural Products
University of Genoa
2010-2022
Marche Polytechnic University
2014-2021
National Cancer Research Institute
2003
University of Naples Federico II
2000
University of Siena
1995
University of Messina
1992
Cell Biotech (South Korea)
1983
The Ocimum genus, collectively called basil, is an important member of the Lamiaceae family. includes more than 100 species herbs and shrubs from tropical region Asia, Africa Central South America. Sweet O. basilicum, a common herb cultivated for culinary purposes as fresh, dried or processed. [...]
Abstract This study presents data suggesting that both human mesothelioma (cell lines and biopsies) normal mesothelial cells express receptors for acetylcholine stimulation of these by nicotine prompted cell growth via activation nicotinic cholinergic receptors. Thus, demonstrate that: (a) biopsies as well pleural functionally α-7 acethlycholine receptors, evaluated α-bungarotoxin-FITC binding, receptor binding assay, Western blot, reverse transcription-PCR; (b) choline acetyltransferase...
Marine ecosystems are increasingly threatened by the release of personal care products. Among them, sunscreens causing concern either for effects on skin protection from UV radiation and potential impacts marine life. Here, we assessed UVA protective efficacy three human dermal fibroblasts, including two common products in Europe USA, an eco-friendly product. The sunscreens' were also tested Paracentrotus lividus, a species possibly these contaminants. We found that all had similar...
Nanoparticles (NPs) contained in commercial products are released and enter into the aquatic ecosystem, posing serious possible risks to environment affecting food chain. Therefore, investigating potential toxicity of NPs on organisms has become an important issue. This study assessed trophic transfer metal oxide from marine microalgae (Cricosphaera elongata) larvae sea urchin Paracentrotus lividus. Larvae (24 h old) were fed 2000 cell mL−1 48 contaminated with 5 mg L−1 several (SiO2, SnO2,...
The aim of the present study was to investigate presence and distribution cholinergic molecules in Balanus amphitrite cyprids their possible involvement settlement adhesion. Acetylcholinesterase (AChE, lythic enzyme acetylcholine) activity detected, for first time, by biochemical histoenzymological methods, thoracic muscles, gut wall cement gland. immunodetection choline acetyltransferase-like (ChAT) same area neuropil central nervous system suggests a innervation, acetylcholine muscular...
The biological function of the cholinesterase (ChE) enzymes has been studied since beginning twentieth century. Acetylcholinesterase plays a key role in modulation neuromuscular impulse transmission vertebrates, while invertebrates pseudo cholinesterases are preeminently represented. During last 40 years, awareness ChEs regulating non-neuromuscular cell-to-cell interactions increasing such as ones occurring during gamete interaction and embryonic development. Moreover, ChE activities...
Metal nanosolicoparticles are suspected to cause diseases in a number of organisms, including man. In this paper, we report the effects nanosilver (Ag, 1–20 nm particles) on early development zebrafish, well-established vertebrate model. Embryos at midgastrula stage were exposed concentrations ranging from 100 0.001 mg/L verify different endpoints: lethality, morphology, expression cholinergic molecules, and immune system. (1) Relative risk mortality was exponential range between 10 mg/L....
A great effort has recently been made to obtain human stem cells able differentiate into cholinergic neurons, as a number of diseases are associated the neuron loss, degeneration or incorrect function (Alzheimer's disease and motor disease). cell population (i.e. pre-adipocytes) is present in adipose stromal compartment. Pre-adipocytes, like mesodermic derivative cells, retain high plasticity potentiality convert vitro from one phenotype many others, they can be isolated adult tissue....