A5054157933- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Reproductive System and Pregnancy
- Muscle Physiology and Disorders
- Mesenchymal stem cell research
- Vibrio bacteria research studies
- Neonatal Respiratory Health Research
- Melanoma and MAPK Pathways
- Long-Term Effects of COVID-19
- Amyotrophic Lateral Sclerosis Research
- Alzheimer's disease research and treatments
- Nanoparticles: synthesis and applications
- Cellular Mechanics and Interactions
- Nutrition and Health in Aging
- Cell Adhesion Molecules Research
- Environmental Toxicology and Ecotoxicology
- Renal and related cancers
- COVID-19 and Mental Health
- Parkinson's Disease Mechanisms and Treatments
- Tissue Engineering and Regenerative Medicine
University of Modena and Reggio Emilia
2011-2024
University of Bologna
2024
Neuroinflammation is involved in neuronal cell death that occurs neurodegenerative diseases such as Alzheimer's disease (AD). Microglia play important roles regulating the brain amyloid beta (Aβ) levels, so immunomodulatory properties exerted by mesenchymal stem cells may be exploited to treat this pathology. The evidence suggests mechanism of action human amniotic fluid (hAFSCs) through their secretome, which includes exosomes (exo).We examined effect derived from (hAFSCs-exo) on activated...
Background—Osteoporosis is characterized by defects in both quality and quantity of bone tissue, which imply high susceptibility to fractures with limitations autonomy. Current therapies for osteoporosis are mostly concentrated on how inhibit resorption but give serious adverse effects. Therefore, more effective safer needed that even encourage formation. Here we examined the effect extracellular vesicles secreted human amniotic fluid stem cells (AFSC) (AFSC-EV) a model vitro. Methods—human...
Alzheimer’s disease (AD) is characterized by abnormal protein aggregation, deposition of extracellular β-amyloid proteins (Aβ), besides an increase oxidative stress. Amniotic fluid stem cells (AFSCs) should have a therapeutic potential for neurodegenerative disorders, mainly through paracrine effect mediated vesicles (EV). Here, we examined the EV derived from human AFSCs (AFSC-EV) on phenotypes in AD neuron primary culture. We observed positive AFSC-EV morphology, viability, and Aβ...
Neuromuscular junctions (NMJs) are specialized synapses, crucial for the communication between spinal motor neurons (MNs) and skeletal muscle. NMJs become vulnerable in degenerative diseases, such as muscle atrophy, where crosstalk different cell populations fails, regenerative ability of entire tissue is hampered. How sends retrograde signals to MNs through represents an intriguing field research, role oxidative stress its sources remain poorly understood. Recent works demonstrate myofiber...
BRAF mutations are present in 30–50% of cases cutaneous melanoma, and treatment with selective MEK inhibitors has been introduced. However, the development resistance to these drugs often occurs. Chemo-resistant melanoma cells show increased expression CD271, a stem cell marker that features migration. Concordantly, inhibitor oncogenic BRAFV600E/K, vemurafenib, is mediated by CD271. It recently shown pathway leads an overexpression NADPH oxidase Nox4, which produces reactive oxygen species...
Mesenchymal stromal cells (MSCs) and their secretome show intrinsic antitumor properties, however, the anti-cancer effects of MSCs remain debated depend on cancer type or model. derived from discarded samples, such as human amniotic fluid (hAFSC), have been introduced an attractive potent stem cell source for clinical applications due to collection procedures, which minimize ethical issues. Until now, various studies obtained controversial results poor understanding mechanisms behind...
Human amniotic fluid cells (hAFSCs) are a fascinating foetal cell-type that have important stem cell characteristics; however, they heterogeneous population ranges from totally differentiated or progenitor to highly multipotent cells. There is no single approach isolating the component, but selection of subpopulation hAFSCs expressing c-Kit widely employed, while deep characterization two populations still lacking. Here we performed single-cell and bulk RNAseq analysis compare gene...