A5015306666- Prenatal Screening and Diagnostics
- Pregnancy and preeclampsia studies
- Maternal and fetal healthcare
- Fetal and Pediatric Neurological Disorders
- Ectopic Pregnancy Diagnosis and Management
- Neonatal Respiratory Health Research
- Assisted Reproductive Technology and Twin Pregnancy
- Congenital Anomalies and Fetal Surgery
- Maternal and Perinatal Health Interventions
- Preterm Birth and Chorioamnionitis
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Parvovirus B19 Infection Studies
- Extracellular vesicles in disease
- Mesenchymal stem cell research
- MicroRNA in disease regulation
- Endometriosis Research and Treatment
- Pregnancy-related medical research
- Tissue Engineering and Regenerative Medicine
- Reproductive Biology and Fertility
- Reproductive System and Pregnancy
- Congenital Diaphragmatic Hernia Studies
- Infant Nutrition and Health
- Ovarian function and disorders
- Muscle Physiology and Disorders
University of Modena and Reggio Emilia
2015-2025
Azienda Ospedaliero-Universitaria di Modena
2006-2024
University of Siena
2006
University of Bristol
2004
Recently, a new marker, the anti-Müllerian hormone (AMH), has been evaluated as marker of ovarian response. Serum AMH levels have measured at frequent time-points during menstrual cycle, suggesting complete absence fluctuation. The aim this study was to evaluate whether serum measurement on any day cycle could predict response in women undergoing assisted reproductive technology (ART).This included 48 attending IVF/ICSI programme. Blood withdrawal for performed all patients independently...
Abstract The cartilage tissue engineering associated with stem cell‐related therapies is becoming very interesting since adult articular has limited intrinsic capacity for regeneration upon injury. Amniotic fluid cells (AFSC) have been shown to produce exosomes growth factors and immunomodulating molecules that could stop degradation induce repair. Based on this state of the art, main aim study was explore efficacy secreted exosomes, compared their AFSC source, in MIA‐induced animal model...
Summary The aim of this study was to assess the relationship between preterm/early preterm delivery and active smoking as well environmental tobacco smoke (ETS) exposure in a sample pregnant Italian women. A case–control conducted nine cities Italy October 1999 September 2000. Cases birth were singleton babies born before 37th gestational week; 35th week considered early births. Controls with ages ≥ week. total 299 cases (including 105 preterm) 855 controls analysed. self‐administered...
Abstract Objectives To assess the risk of fetal loss attributable to second trimester amniocentesis in singleton pregnancies through a cross‐sectional study. Methods Records 5043 consecutive amniocentesis, performed by single operator between 1997 and 2003, were analyzed. Fetal post was calculated grouping pregnant women age classes assessing observed/expected (O/E) rate. Results Total losses 40 (0.81%): 33 cases (0.67%) occurred before 24th week, 37 (0.76%) 28th gestational 3 (0.06%) after...
ABSTRACT Objective To evaluate the performance of third‐trimester ultrasound for diagnosis clinically significant placenta accreta spectrum disorder (PAS) in women with low‐lying or previa. Methods This was a prospective multicenter study pregnant aged ≥ 18 years who were diagnosed (< 20 mm from internal cervical os) previa (covering on at 26 + 0 weeks' gestation, between October 2014 and January 2019. Ultrasound suspicion PAS raised presence least one these signs grayscale ultrasound:...
<h3>BACKGROUND AND PURPOSE:</h3> Normal biometry of the fetal posterior fossa rules out most major anomalies cerebellum and vermis. Our aim was to provide new reference data vermis in 4 biometric parameters by using 3 imaging modalities, 2D ultrasound, 3D MR imaging, assess relation among these modalities. <h3>MATERIALS METHODS:</h3> A retrospective study conducted between June 2011 2013. Three different modalities were used measure biometry: imaging. The vermian evaluated maximum...
Background—Osteoporosis is characterized by defects in both quality and quantity of bone tissue, which imply high susceptibility to fractures with limitations autonomy. Current therapies for osteoporosis are mostly concentrated on how inhibit resorption but give serious adverse effects. Therefore, more effective safer needed that even encourage formation. Here we examined the effect extracellular vesicles secreted human amniotic fluid stem cells (AFSC) (AFSC-EV) a model vitro. Methods—human...
The purposes of this study were to describe a 3-dimensional sonographic technique for evaluation the fetal vermis and compare vermian biometric parameters in fetuses with normal an abnormal posterior fossa.A prospective was conducted from 2006 through 2008 on 12 fossa 73 healthy control 18 35 weeks' gestation. Three-dimensional scans head performed axial plane, using static volume contrast imaging C-plane. perimeter, cross-sectional area, superoinferior diameter measured compared between...
Alzheimer’s disease (AD) is characterized by abnormal protein aggregation, deposition of extracellular β-amyloid proteins (Aβ), besides an increase oxidative stress. Amniotic fluid stem cells (AFSCs) should have a therapeutic potential for neurodegenerative disorders, mainly through paracrine effect mediated vesicles (EV). Here, we examined the EV derived from human AFSCs (AFSC-EV) on phenotypes in AD neuron primary culture. We observed positive AFSC-EV morphology, viability, and Aβ...
Neuromuscular junctions (NMJs) are specialized synapses, crucial for the communication between spinal motor neurons (MNs) and skeletal muscle. NMJs become vulnerable in degenerative diseases, such as muscle atrophy, where crosstalk different cell populations fails, regenerative ability of entire tissue is hampered. How sends retrograde signals to MNs through represents an intriguing field research, role oxidative stress its sources remain poorly understood. Recent works demonstrate myofiber...
Human amniotic fluid stem cells (hAFSCs) are broadly multipotent immature progenitor with high self-renewal and no tumorigenic properties. These cells, even amplified, present very variable morphology, density, intracellular composition stemness potential, this heterogeneity can hinder their characterization potential use in regenerative medicine. Celector® (Stem Sel ltd.) is a new technology that exploits the Non-Equilibrium Earth Gravity Assisted Field Flow Fractionation principles to...
Birth prior to 37 completed weeks of gestation is referred as preterm (PT). Premature newborns are at increased risk developing infections neonatal immunity a structure. Monocytes, which key players after birth, activate inflammasomes. Investigations into the identification innate immune profiles in premature compared full-term infants limited. Our research includes investigation monocytes and NK cells, gene expression, plasma cytokine levels investigate any potential differences among...
Preterm birth is still the leading cause of neonatal morbidity and mortality. The level corticotropin-releasing hormone (CRH) known to be significantly elevated in maternal plasma at preterm birth. Although, CRH, CRH-binding protein (CRH-BP), CRH-receptor 1 (CRH-R1) CRH-R2 have been identified both mRNA human placenta, deciduas, fetal membranes, endometrium myometrium, no corresponding information yet available on cervix. Thus, aim this study was compare levels species coding for CRH-BP,...
Objectives The purpose of this study was to evaluate the feasibility visualization and measurement pericallosal artery during early stages gestation. Methods group comprised 80 pregnant women between 12 21 weeks' gestation who attended our ultrasound unit. Transabdominal or transvaginal sonography performed obtain optimal angle a midsagittal section. High‐definition flow power Doppler imaging used visualize artery. In sagittal plane, lengths were measured using straight line connect most...
Human amniotic fluid stem cells (hAFSCs) are an emerging tool in regenerative medicine because they have the ability to differentiate into various lineages and efficiently improve tissue regeneration with no risk of tumorigenesis. Although hAFSCs easily isolated from fluid, their expansion ex vivo is limited by a quick exhaustion which impairs replicative potential differentiation capacity. In this study, we evaluate aging features cultured at different oxygen concentrations. We show that...
COVID-19 was declared to be a pandemic due the rapid increase of cases around world, including number pregnant women. Data about vertical transmission are still limited and controversial: in most cases, although positive mother, virus could not isolated amniotic fluid, cord blood, breast milk or neonatal throat swab these patients. No data have been published possible intrauterine sonographic signs infection. A woman diagnosed with SARS-CoV-2 at 35+5 weeks gestation managed conservatively...
The thymus has a pyramidal shape, which is best shown in coronal planes. aim of this study was to evaluate the potential virtual organ computer-aided analysis estimate fetal volume normal pregnancies.Three-dimensional data sets from axial upper mediastinal section were acquired 37 pregnancies between 12 and 35 weeks' gestation. Thymus calculated by 2 separate examiners. In cases, volumes also with 4-dimensional sonography spatiotemporal image correlation software assess variability size...
Introduction: The role of cerebroplacental ratio (CPR) or umbilicocerebral (UCR) to predict adverse intrapartum and perinatal outcomes in pregnancies complicated by late fetal growth restriction (FGR) remains controversial. Methods: This was a multicenter, retrospective cohort study involving 5 referral centers Italy Spain, including singleton FGR, as defined Delphi consensus criteria, with scan 1 week prior delivery. primary objective compare the diagnostic accuracy CPR UCR for prediction...
This is the first national population-based report about prenatal diagnosis for families with a history of facioscapulohumeral muscular dystrophy (FSHD), complex hereditary disease. The incomplete disease penetrance and phenotypic heterogeneity observed in carriers D4Z4 alleles reduced size, FSHD molecular hallmark, make estimate genetic risk problematic.We considered all requests preconception counseling received between January 2008 December 2020 by service associated Italian National...
To investigate the value of a new cervical sonographic sign, called jellyfish sign (JS), for predicting risk maternal morbidity in cases abnormally invasive placenta (AIP) previa totalis. Retrospective evaluation transvaginal (TV) and transabdominal (TA) scans performed all singleton pregnancies with JS, i. e. absence normal linear demarcation between cervix, was evaluated by TV scans. The presence/severity AIP outcomes were related to this sign. JS noted 8/39 (20.5 %) patients. two analyzed...