A5069002036- Tracheal and airway disorders
- Head and Neck Surgical Oncology
- Voice and Speech Disorders
- Sinusitis and nasal conditions
- Antimicrobial Resistance in Staphylococcus
- Ear Surgery and Otitis Media
- Hearing, Cochlea, Tinnitus, Genetics
- Thyroid and Parathyroid Surgery
- Hearing Loss and Rehabilitation
- Head and Neck Cancer Studies
- Vestibular and auditory disorders
- Allergic Rhinitis and Sensitization
- Obstructive Sleep Apnea Research
- Immune Response and Inflammation
- Teratomas and Epidermoid Cysts
- Cancer Diagnosis and Treatment
- Nasal Surgery and Airway Studies
- Oral and Maxillofacial Pathology
- Salivary Gland Tumors Diagnosis and Treatment
- Bacterial Infections and Vaccines
- Asthma and respiratory diseases
- Head and Neck Anomalies
- Streptococcal Infections and Treatments
- Antimicrobial Peptides and Activities
- Ear and Head Tumors
Istituto Ortopedico Gaetano Pini
2017-2025
University of Messina
2016-2025
Azienda Ospedaliera Universitaria Policlinico "G. Martino"
2014-2021
Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo
2021
Fundación Juan March
2020
Policlinico Universitario di Catania
2012-2019
Toscana Life Sciences
2016-2017
Novartis (Italy)
2011-2016
Novartis (Switzerland)
2015
Istituto di Genetica Molecolare
2009
Both active and passive immunization strategies against Staphylococcus aureus have thus far failed to show efficacy in humans. With the attempt develop an effective S. vaccine, we selected five conserved antigens known different roles pathogenesis. They include secreted factors α-hemolysin (Hla), ess extracellular A (EsxA), B (EsxB) two surface proteins ferric hydroxamate uptake D2 staphylococcal antigen 1A. The combined vaccine formulated with aluminum hydroxide induced antibodies...
Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by a type 2 pattern of inflammation resulting in the production some cytokines. Dupilumab radically changes treatment CRSwNP, but, considering its recent approval, it may be useful to evaluate safety profile real-world setting. This work aimed prospectively highlight effectiveness and dupilumab patients CRSwNP enrolled Otorhinolaryngology Unit University Hospital Messina. An observational cohort study was carried out all...
Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by a type 2 pattern of inflammation. Mepolizumab was approved for the treatment CRSwNP in 2021. However, there lack real-life studies. This work aimed to evaluate effectiveness and safety profile during first year setting. A multicentric observational cohort study carried out. total 67 patients were enrolled Otorhinolaryngology Unit three University Hospitals considered therapy. All recorder characteristics age (at...
This study aimed to evaluate the effectiveness and safety of dupilumab during first year treatment in a real-life setting, focusing on improvement nasal polyp score (NPS) as well specific symptoms, quality life olfactory function.A multicentric observational cohort was carried out. A total 170 patients were enrolled Otorhinolaryngology Unit three University Hospitals considered for therapy. All recorder characteristics age (at application visit), sex, smoke habits, previous local systemic...
A rapidly acting, single dose vaccine against Staphylococcus aureus would be highly beneficial for patients scheduled major surgeries or in intensive care units. Here we show that one immunization with a multicomponent S. candidate vaccine, 4C-Staph, formulated novel TLR7-dependent adjuvant, T7-alum, readily protected mice from death and bacterial dissemination, both kidney abscess peritonitis models, outperforming alum-formulated vaccine. This increased efficacy was paralleled by higher...
A resurgence of whooping cough (pertussis) has been observed in recent years a number developed countries, despite widespread vaccine coverage. Although the exact reasons recurrence pertussis are not clear, there potential causes, like antigenic variation circulating strains Bordetella pertussis, changes surveillance and diagnostic tools, differences protection afforded by current acellular (aP) vaccines compared to more reactogenic whole cell (wP) vaccines, which they replaced. Studies...
Staphylococcus aureus is the major cause of human septic arthritis and osteomyelitis, which deserve special attention due to their rapid evolution resistance treatment. The progression disease depends on both bacterial presence in situ uncontrolled disruptive immune response, responsible for chronic disease. Articular bone infections are often result blood bacteremia, with knees hips being most frequently infected joints showing worst clinical outcome. We report development a hematogenous...
Streptococcus pneumoniae pilus 1 is present in 30 to 50% of invasive disease-causing strains and composed three subunits: the adhesin RrgA, major backbone subunit RrgB, minor ancillary protein RrgC. RrgB exists distinct genetic variants and, when used immunize mice, induces an immune response specific for each variant. To generate antigen able protect against infection caused by all pilus-positive S. strains, we engineered a fusion containing (RrgB321). RrgB321 elicited antibodies proteins...
The aim of the present study was to compare posterior tympanotomy (PT) technique endomeatal approach. approach (EMA) for Cochlear Implant (CI) surgery performed on 98 patients with procident lateral sinus or a small mastoid cavity, 103 ears (Group A). Conventional mastoidectomy and PT other 104 patients, 107 B). Data all were then collected following: intra- post-operative complications, Tinnitus Handicap Inventory (THI), Vertigo Symptom Scale (VSS), duration surgery, postoperative...
Nasal polyps (NPs) represent the end-stage manifestation of chronic rhinosinusitis (CRS), a relatively common pathological condition encountered in all ages life. The aim our study was to evaluate histological features and inflammatory cellular components NPs retrospective cohort (143 cases) pediatric, adult elderly populations order discuss possible morphological age-related differences statistically documented. In pediatric group, infiltrate presented many eosinophils mixed with...
Recently we reported the pharmacological characterization of 9,10-dihydropyrrolo[1,3]benzothiazepine derivative (S)-(+)-8 as a novel atypical antipsychotic agent. This compound had an optimum pKi 5-HT2A/D2 ratio 1.21 (pKi 5-HT2A = 8.83; D2 7.79). The lower receptor affinity compared to its enantiomer was explained by difficulty in reaching conformation required optimally fulfill pharmacophore. With aim finding antipsychotics further investigated core structure (S)-(+)-8, synthesizing...
Injuries to the internal carotid artery during simple pharyngeal surgical procedures can be catastrophic for risk of massive bleeding. The aims study were 1) report five cases congenital and asymptomatic anomalies with a review literature, 2) assess relationships between these possible in "routine" surgery, 3) determine most accurate imaging techniques evaluate anomalies.Retrospective patients bulging wall. METHODS Clinical records, pathology reports, original features kind vascular lesions...
ABSTRACT Staphylococcus aureus is a human bacterial pathogen causing variety of diseases. The occurrence multidrug-resistant strains underlines the need for vaccine. Defining immune correlates protection may support design an effective We used murine infection model, in which bacteria were inoculated air pouch generated on back animal. Analysis air-pouch content mice immunized or not with adjuvanted multiantigen vaccine formulation, four-component S. (4C-Staph), prior to allowed us measure...
Several guidelines on adeno-tonsillar disease have been proposed in recent years and some discrepancies relation both to clinical manifestations indications for surgical treatment emerged. The aim of the study was verify what influence (adeno)-tonsillectomy had behaviour ENT specialists Italy. Our is a retrospective multi-centre case series with chart review.The survey involved 14,770 children, aged between ages 2 11, who undergone surgery 2002 2008 fourteen Italian tertiary secondary...