A5022547731- Thyroid Cancer Diagnosis and Treatment
- Head and Neck Anomalies
- Thyroid and Parathyroid Surgery
- Salivary Gland Tumors Diagnosis and Treatment
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Neuroendocrine Tumor Research Advances
- Ovarian cancer diagnosis and treatment
- BRCA gene mutations in cancer
- Parathyroid Disorders and Treatments
- Antibiotic Resistance in Bacteria
- Viral-associated cancers and disorders
- Ear and Head Tumors
- Monoclonal and Polyclonal Antibodies Research
- Oral and Maxillofacial Pathology
- Bacterial Identification and Susceptibility Testing
- Medical Imaging and Pathology Studies
- Cervical Cancer and HPV Research
- Cancer-related Molecular Pathways
- Antifungal resistance and susceptibility
- Radiomics and Machine Learning in Medical Imaging
- Pancreatic and Hepatic Oncology Research
- Genetic factors in colorectal cancer
- Antimicrobial Resistance in Staphylococcus
- Fungal Infections and Studies
Istituto Ortopedico Gaetano Pini
2020-2025
University of Messina
2020-2025
Università Cattolica del Sacro Cuore
2014-2024
Agostino Gemelli University Polyclinic
2015-2024
Beth Israel Deaconess Medical Center
2023-2024
The University of Texas MD Anderson Cancer Center
2023-2024
Massachusetts General Hospital
2013-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2024
Faculty of Media
2023
Azienda Ospedaliera Universitaria Policlinico "G. Martino"
2020
Activating mutations of BRAF have been identified in a variety human cancers, most notably melanomas and papillary thyroid carcinomas (PTCs). The aim the present study was to disclose role carcinoma development. Seventy-two tumors, including 60 PTCs, six follicular adenomas, five carcinomas, one anaplastic carcinoma, were studied. mutation screening focused on exon 15 11 gene by single-stranded conformational polymorphism sequence analysis. Search RET/PTC expression conducted with RT-PCR...
Summary Background Metastases to thyroid (TM) are rarely observed in the clinical practice. Objective To assess prevalence, clinicopathological aspects and prognosis of TM, evaluate role thyroidectomy management TM. Methods The pathology files (databases) two Italian Pathology Units were searched for cytology (FNAC) histology reports covering time period January 1993 through December 2003. Results Thirty‐six cases TM found, accounting 0·13% thyroidectomies 0·07% FNAC. main site origin was...
Journal Article Antibacterial activity of ozonized sunflower oil (Oleozon) Get access L.A. Sechi, Sechi Dipartimento di Scienze Biomediche, Università degli studi Sassari, Italy Search for other works by this author on: Oxford Academic Google Scholar I. Lezcano, Lezcano Centro Nacional de Investigaciones Cientificas, Ciudad l'Habana, Cuba N. Nunez, Nunez M. Espim, Espim Duprè, Duprè A. Pinna, Pinna Istituto Oftalmologia, P. Molicotti, Molicotti G. Fadda, Fadda Microbiologia, Facoltà Medicina...
Enterococci are widely distributed in the environment; within human body, they normal commensals of oral cavity, gastrointestinal tract and vagina. In recent years, enterococci have become one most frequent causes acquired nosocomial infections worldwide. The molecular mechanism virulence these bacteria is still not completely understood. aims this work were to characterize phenotypically 47 isolates Enterococcus faecalis faecium collected Sardinia (Italy) by their abilities adhere different...
To characterize linezolid resistance among blood cultured Staphylococcus epidermidis from patients at the Polyclinic Agostino Gemelli (2006–08). Isolates also showed elevated MICs of macrolide, lincosamide and streptogramin (MLS) compounds, which were investigated. Ten S. exhibiting ≥ 4 mg/L included. screened for cfr mutations in 23S rRNA, L3, L4 L22, MLS genes by PCR/sequencing. Ribosomal proteins compared with those a linezolid-susceptible (MIC, 1 mg/L) clinical strain ATCC 12228....
BACKGROUND Fine‐needle aspiration cytology (FNAC) has proven its value as an essential step in the diagnosis of salivary gland lesions. Although majority lesions, especially those that are common and benign, can be diagnosed with ease on FNAC, limited cellularity morphologic lesion heterogeneity pose diagnostic challenges lead to false‐positive false‐negative diagnoses. This study presents institutional experience FNAC lesions from 2 academic centers. METHODS A retrospective analysis was...
The change in the diagnosis of noninvasive encapsulated follicular variant papillary thyroid carcinoma to neoplasm with papillary‐like nuclear features (ie, not carcinoma) will have significant impact on risk malignancy for categories according Bethesda System Reporting Thyroid Cytopathology, and especially indeterminate categories.
BACKGROUND Activating mutations in the valine‐to‐glutamic acid substitution at position 600 of v‐raf murine sarcoma viral oncogene homolog B1 ( BRAF‐1 ) gene are detected frequently patients with papillary thyroid carcinoma (PTC). These have been identified approximately 29% to 69% PTCs and >80% tall cell variant, whereas they not benign lesions or majority those (80%) follicular variant PTC. The objective current study was evaluate role liquid‐based cytology (LBC) for detection BRAF...
ABSTRACT An Italian nationwide survey was carried out to assess the prevalences and antimicrobial susceptibilities of members family Enterobacteriaceae producing extended-spectrum β-lactamases (ESBLs). Over a 6-month period, 8,015 isolates were obtained from hospitalized patients screened for resistance cephalosporins monobactams. On basis synergistic effect between clavulanate selected β-lactams (ceftazidime, aztreonam, cefotaxime, cefepime, ceftriaxone), 509 found be ESBL positive (6.3%)....
Abstract The thyroid fine‐needle aspiration (FNA) diagnosis of Hürthle‐cell neoplasm (HCN)/follicular with oncocytic features (FNOF) does not differentiate between adenoma and carcinoma. A majority cases diagnosed as HCN undergo surgical excision for definite characterization. aim this study was to determine the risk malignancy in identify clinical that may help predicting patients FNA HCN. We reviewed a cohort 206 HCN; histological follow‐up available 169 (82%) cases. were evaluated...
Fine-needle aspiration biopsy (FNAB) is the most reliable diagnostic tool in diagnosis of thyroid nodules. A cytologic follicular neoplasm with atypical cells undetermined significance (FN/AUS) implies that selection patients between surgery and follow-up difficult. In this setting immunocytochemical stainings might be helpful. The efficacy a panel made up HBME-1 Galectin-3 antibodies evaluated cases processed by liquid-based cytology (LBC).Out 7091 FNAB LBC method, 120 undergoing...
Background and Aim Papillary thyroid carcinomas smaller than 1 cm are classified as papillary microcarcinomas (PMCs). usually considered low-risk tumors; however in some cases, PMCs behave aggressively metastasize early, giving rise to clinically metastatic disease. Debate exists the literature about prognostic factors therapeutic management PMC. We report here long-term experience of our referral center for malignant Methods retrospectively analyzed 149 consecutive patients with PMC who...
The incidence of human papillary thyroid cancer (PTC) is increasing and an aggressive subtype this disease resistant to treatment with vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor. VEGFR2 promotes angiogenesis by triggering cell proliferation migration. However, the molecular mechanisms governing stability in vivo remain unknown. Additionally, whether influences PTC migration not clear. We show that ubiquitin E3 ligase SCFβ-TRCP ubiquitination destruction a casein kinase...
The introduction of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) affects the risk malignancy (ROM) mostly in Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) categories. In this multi-institutional, retrospective study, authors investigated variations impact an NIFTP diagnosis on associated ROM each TBSRTC category emphasis influence pathologist and institutional diagnostic thresholds ROM.Baseline data cytology histology categories were...
Fine needle aspiration (FNA) is widely used in the diagnosis of salivary gland lesions. Salivary FNAs are often difficult to diagnose because morphologic heterogeneity, a small but significant number yield "atypical" diagnosis. However, systematic evaluation risk malignancy (ROM) atypical diagnoses across institutions and variability ROM among still lacking.Salivary from five tertiary medical centers United States, Europe China were reviewed. Cases with histological follow-up included this...