A5084306633- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Microtubule and mitosis dynamics
- Melanoma and MAPK Pathways
- PI3K/AKT/mTOR signaling in cancer
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Histone Deacetylase Inhibitors Research
- Genomics and Chromatin Dynamics
- DNA Repair Mechanisms
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Metabolism, Diabetes, and Cancer
- Peptidase Inhibition and Analysis
- interferon and immune responses
- Endoplasmic Reticulum Stress and Disease
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- Cell Adhesion Molecules Research
- 14-3-3 protein interactions
- Hippo pathway signaling and YAP/TAZ
- Cancer Research and Treatments
- Chromatin Remodeling and Cancer
- Protein Kinase Regulation and GTPase Signaling
Molecular Oncology (United States)
2016-2024
Moffitt Cancer Center
2016-2024
Henan University
2021-2023
Nanyang Institute of Technology
2016-2022
Beth Israel Deaconess Medical Center
2011-2020
Harvard University
2011-2020
Zhengzhou University
2016-2018
Harvard University Press
2010-2013
Pediatrics and Genetics
2012
Dana-Farber Cancer Institute
2012
Activation of tumor suppressors for the treatment human cancer has been a long sought, yet elusive, strategy. PTEN is critical suppressive phosphatase that active in its dimer configuration at plasma membrane. Polyubiquitination by ubiquitin E3 ligase WWP1 (WW domain-containing 1) suppressed dimerization, membrane recruitment, and function PTEN. Either genetic ablation or pharmacological inhibition triggered reactivation unleashed activity. appears to be direct MYC (MYC proto-oncogene)...
Mitochondrial dynamics homeostasis is important for cell metabolism, growth, proliferation, and immune responses. The critical GTPase mitochondrial fission, Drp1 frequently upregulated in many cancers closely implicated tumorigenesis. However, the mechanism underling to influence tumor progression largely unknown, especially esophageal squamous carcinoma (ESCC).Immunohistochemistry was used examine LC3B expression tissues of ESCC patients. Autophagic vesicles were investigated by...
The incidence of human papillary thyroid cancer (PTC) is increasing and an aggressive subtype this disease resistant to treatment with vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor. VEGFR2 promotes angiogenesis by triggering cell proliferation migration. However, the molecular mechanisms governing stability in vivo remain unknown. Additionally, whether influences PTC migration not clear. We show that ubiquitin E3 ligase SCFβ-TRCP ubiquitination destruction a casein kinase...