A5058692857- Management of metastatic bone disease
- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Cancer, Hypoxia, and Metabolism
- Cancer Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Cervical and Thoracic Myelopathy
- RNA modifications and cancer
- Spinal Hematomas and Complications
- Brain Metastases and Treatment
- Cardiac tumors and thrombi
- Soft tissue tumor case studies
- Histone Deacetylase Inhibitors Research
- Medical Imaging and Pathology Studies
- Cancer-related gene regulation
- Musculoskeletal synovial abnormalities and treatments
- Epigenetics and DNA Methylation
- Neuroblastoma Research and Treatments
- Spinal Cord Injury Research
- Protein Degradation and Inhibitors
- Cardiac Ischemia and Reperfusion
- Aortic Disease and Treatment Approaches
- Diet and metabolism studies
Shanghai Changzheng Hospital
2018-2025
Hunan Normal University
2024
Changsha Hospital for Maternal and Child Health Care
2024
Second Military Medical University
2016-2023
University of Shanghai for Science and Technology
2022-2023
Open Evidence
2023
Ethics and Public Policy Center
2023
Weatherford College
2023
Beth Israel Deaconess Medical Center
2021
Harvard University
2021
// Xin-gang Cui 2, * , Zhi-tao Han 1, 6, Shao-hui He Xing-da Wu 3, Tian-rui Chen 1 Cheng-hao Shao 4 Dan-lei Ning Su 5 Yuan-ming 6 Ting Wang Jing Dian-Wen Song Wang-jun Yan Xing-Hai Yang Tielong Liu Hai-feng Wei Jianru Xiao Department of Bone Tumor Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China 2 Urinary Surgery Third Affiliated 3 Pancreatic the First Hospital Shenyang, Colorectal Spine Ruikang Guangxi University Of Chinese Medicine, Guangxi, Cui, Han, He,...
Abstract The Wnt/β-catenin signaling is abnormally activated in the progression of hepatocellular carcinoma (HCC). BCL9 an essential co-activator signaling. Importantly, absent from tumors originating normal cellular counterparts and overexpressed many cancers including HCC. But mechanism for overexpression remains unknown. Ample evidence indicates that hypoxia inducible factors (HIFs) play a role development It was found our study both primary HCC bone metastasis specimens; loss inhibited...
Background and Objective Unilateral biportal endoscopy (UBE) has been developing rapidly in coincidence with the popularization of minimally invasive spine surgery (MISS). However, clinical outcome invasiveness UBE-assisted spinal (UBESS) are undefined. The aim present study was to summarize surgical UBE for treatment various degenerative diseases a single center validate safety application value UBESS. Methods Included this were 105 patients who received UBESS from November 2021 June 2022...
Abstract Background The extracellular matrix has been critically associated with the tumorigenesis and progression of Ewing sarcoma (ES). However, regulatory prognostic roles tenascin-C (TNC) in ES remain unclear. Methods TNC expression was examined specimens by immunohistochemistry, association patient survival also analysed. TNC-knockout cell lines were constructed using CRISPR/Cas9 methods. In vitro experiments vivo bioluminescent imaging BALB/c nude mice conducted to evaluate effect on...
Background: Patients with spinal metastasis from cancer of unknown primary origin have limited life expectancy and poor quality life. Surgery radiation therapy remain the main treatment options, but, to our knowledge, there are data concerning quality-of-life improvement after surgery even fewer on whether surgical intervention would affect Methods: were enrolled between January 2009 2014 at Changzheng Hospital, Shanghai, People’s Republic China. The 2 patient groups (one group that...
The purpose of our study is to identify the predictive factors for a minimum clinically successful therapy after extracorporeal shock wave chronic plantar fasciitis. demographic and clinical characteristics were evaluated. artificial neural networks model was used choose significant variables effect achieving at 6-months' follow-up. multilayer perceptron selected. Higher VAS (Visual Analogue Score) when taking first steps in morning, presence fascia spur, shorter duration symptom had...
Abstract BACKGROUND Radical resection is the first-line option in managing cervical primary chondrosarcoma. Favorable anterior reconstruction challenging after multilevel total spondylectomy spine. OBJECTIVE To illustrate application of piezoelectric surgery and three-dimensional (3D) printing techniques spine surgery. METHODS A 27-yr-old patient was referred to our center with complaints nocturnal neck pain right upper extremity weakness. 2-stage radical tumor conducted using pathologically...
Bone metastasis from cancer of unknown primary (BMCUP) brings poor survival prognosis and its management remains controversial. Sunitinib (SUTENT) proved effective in many sorts solid tumors but has never been applied for patients with occult cancers, there is no study to identify sensitive or resistant biomarkers sunitinib therapy CUP patients. An analysis was carried out investigate the efficacy by multivariate 286 BMCUP. We further histological clinical that could predict sensitivity...
Study Design. Retrospective analysis. Objective. The study was designed to: (1) figure out risk factors of metastasis; (2) explore prognostic and develop a nomogram for pelvis spine Ewing sarcoma (PSES). Summary Background Data. Tools to predict survival PSES are still insufficient. Nomogram has been widely developed in clinical oncology. Moreover, metastasis unclear. Methods. data were collected analyzed from the Surveillance, Epidemiology, End Results (SEER) database. optimal cutoff values...
A retrospective study was performed.As predictors of intraoperative blood loss have not yet been well defined, the objective present is to develop a model predict amount in metastatic spine tumor surgery.Massive huge challenge surgery. Misjudgment preoperative planning may result disastrous consequences.Enrolled this analysis were 392 patients who received 423 surgeries vertebrectomy and reconstruction our hospital between 2011 2017. Risk factors for high-volume identified by univariate...
Synovial sarcoma (SS) is a soft tissue that rarely occurs in the spine, and minimal number of cases have been reported literature. Spinal SS challenging diagnosis treatment has poor prognosis. The aim this study was to summarize analyse clinical features outcomes patients with spinal SS. A total 16 admitted our institution were reviewed retrospectively. General information, radiological findings strategies collected. These followed up regarding their continuing treatment, local or distant...
The surgical treatment of an upper cervical spinal tumor (UCST) at C1-2/C1-3 is challenging due to anterior exposure and reconstruction. Limited information has been published concerning the effective approach reconstruction for procedure after UCST resection. authors attempted introduce a novel, customized, craniocervical between occipital condyles inferior vertebrae through modified high-cervical retropharyngeal (mHCRA) in addressing tumors.
The therapeutic strategy of Ewing sarcoma (EWS) remains largely unchanged over the past few decades. Hypoxia is reported to have an impact on tumor cell progression and regarded as a novel potential target in treatment. This study aimed at developing prognostic gene signature based hypoxia-related genes (HRGs). EWS patients from GSE17674 GEO database were analyzed training cohort, differently expressed HRGs between normal samples identified. univariate Cox regression, Least Absolute...
Background. Ferroptosis has gained significant attention from oncologists as a vital outcome of oxidative stress. The aim this study was to develop prognostic signature that based on the ferroptosis-related genes (FRGs) for osteosarcoma patients and explore their specific role in osteosarcoma. Methods. training cohort dataset extracted Therapeutically Applicable Research Generate Effective Treatments (TARGET) database. Different techniques like univariate Cox regression, least absolute...
// Shaohui He 1,* , Haifeng Wei Yifei Ma Jian Zhao 1 Xu and Jianru Xiao Department of Orthopedic Oncology, Spinal Tumor Center, Changzheng Hospital, Second Military Medical University, Shanghai, China * These authors have contributed equally to this study Correspondence to: Xiao, email: Xu, Keywords : metastatic spinal cord compression, hepatocellular carcinoma, multidisciplinary treatments, progression-free survival Received October 04, 2016 Accepted January 10, 2017 Published February 25,...