A5107499226- Virus-based gene therapy research
- Management of metastatic bone disease
- Bone Tumor Diagnosis and Treatments
- Liver Disease Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Cancer Diagnosis and Treatment
- Medical Imaging and Analysis
- CAR-T cell therapy research
- Cancer Research and Treatments
- Heart Failure Treatment and Management
- Pelvic and Acetabular Injuries
- Sarcoma Diagnosis and Treatment
- Mechanisms of cancer metastasis
- Cervical and Thoracic Myelopathy
- Lung Cancer Treatments and Mutations
- Cancer-related Molecular Pathways
- Antiplatelet Therapy and Cardiovascular Diseases
- HER2/EGFR in Cancer Research
- Immunotherapy and Immune Responses
- Spine and Intervertebral Disc Pathology
- Liver Disease and Transplantation
- Spinal Fractures and Fixation Techniques
- Cancer Cells and Metastasis
- Gastroesophageal reflux and treatments
- Animal Virus Infections Studies
Yangtze University
2025
Fuyang City People's Hospital
2025
First People's Hospital of Jingzhou
2025
Chinese PLA General Hospital
2010-2024
Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine
2024
Shanghai Changzheng Hospital
2017-2024
Second Military Medical University
2013-2023
Fujian Academy of Agricultural Sciences
2013-2022
Shandong First Medical University
2021
Air Force Medical University
2015-2020
Background: Sodium–glucose cotransporter-2 (SGLT2) inhibitors have been shown to decrease the adverse cardiac events and risks of cardiovascular mortality among patients with or without diabetes, which has made these drugs promising treatment options for chronic heart failure. Cardiac dysfunction is a common severe side effect induced by cancer chemotherapies, seriously affects prognosis life quality tumor patients. However, it not clear whether SGLT2 benefits in chemotherapy–related...
Abstract Purpose: To investigate the expression of myeloid differentiation factor 88 (MyD88) in hepatocellular carcinoma (HCC) and its prognostic value patients with HCC. Experimental Design: Expression MyD88 was detected by immunohistochemistry surgical HCC specimens (n = 110). The correlation to clinicopathologic characteristics analyzed. involvement tumor growth invasion investigated. Results: significantly higher tumors than that adjacent nontumor tissues. Particularly, high found HCCs...
// Jiao Yuan 1, 2, 3, * , Haiyan Yue Meiying Zhang 4 Jianjun Luo 2 Lihui Liu 3 Wei Wu Tengfei Xiao Xiaowei Chen Xiaomin Dongdong Rui Xing 5 Xin Tong 6 Nan Jian Zhao 6, 7 Youyong Lu Mingzhou Guo Runsheng 1 Key Laboratory of RNA Biology, Institute Biophysics, Chinese Academy Sciences, Beijing 100101, China Noncoding RNA, University 100049, Department Gastroenterology and Hepatology, PLA General Hospital, 100853, Molecular Oncology, Carcinogenesis Translational Research (Ministry Education),...
The vicious invasive alien plant
Stroke is a cerebrovascular disease that the main cause of death and disability worldwide. Hypoxia major factor causes neuronal damage even cellular death. However, mechanism therapeutic drugs for hypoxia are not completely understood. In this study, PC12 cells (a rat adrenal pheochromocytoma cell line) were exposed to Cobalt chloride (CoCl2) induce hypoxia. Using model, impacts on viability, proliferation, reactive oxygen species (ROS), levels lysine β-hydroxybutyrylation (Kbhb)...
This study aimed to investigate the regulatory effect of linc00963 on postmenopausal osteoporosis and potential molecular mechanisms. Taking MC3T3-E1 cells as object, a cell cycle assay was used evaluate proliferation. mRNA levels Runx2, OCN, collagenia-1, OPG, RANKL RANK were detected. Dual luciferase reporter verified targeting relationship between miR-506-3p. A rat model established after ovariectomy in 32 Sprague-Dawley rats. The rats divided into sham group, OVX overexpression blank...
Autophagy is an important catabolic process, which sustains intracellular homeostasis and lengthens cell survival under stress. Here we identify the ankyrin-repeat-containing, SH3-domain-containing, proline-rich region-containing protein 2 (ASPP2), a haploinsufficient tumor suppressor, as molecular regulator of starvation-induced autophagy in hepatocellular carcinoma (HCC). ASPP2 expression associated with autophagic response upon nutrient deprivation downregulation facilitates flux, whereas...
// Fangfang Bu 1,2,3,* , Xing Liu 4,* Jingjing Li 1,* Shukun Chen 1 Xin Tong 1,2,3 Chunsheng Ma 4 Hui Mao Fei Pan Xiaoyan 1,2 Bo 5 Liyan Xu Enmin Geng Kou 1,2,6 Jun Han 6 Shangjing Guo Jian Zhao and Yajun 1,2,3,6 PLA General Hospital Cancer Center Key Lab, Medical School of Chinese PLA, Beijing, P.R. China 2 International Joint Institute, The Second Military University, Shanghai, P.R.China 3 Beijing Laboratory Cell Engineering & Antibody, 150 Luoyang, Department Biochemistry Molecular...
Upregulation of osteopontin (OPN) has been found in hepatic progenitor cells (HPCs) several liver diseases with portal biliary proliferation. Here, we investigated the role HPC-derived autocrine OPN regulating HPC expansion, migration, and hepatocarcinogenesis mice. Five-week-old, weighing between 18 20 g either wild type (WT) or gene knockout (OPN-KO) male mice were treated modified choline-deficient, ethionine-supplemented diet (modified choline-deficient [MCDE]) for 2 weeks to induce...
Retrospective study.The aim of this study was to develop a model for predicting survival patients with non-small cell lung cancer (NSCLC) spinal metastasis and compare its accuracy the existing scoring systems.Spinal is commonly seen in advanced NSCLC usually associated poor prognosis.A total 376 metastases admitted our institution from January 2010 October 2016 were enrolled. They randomly assigned at 3:1 ratio training cohort (n = 282) validation 94). A nomogram prediction established by...
Pancreatic ductal adenocarcinoma (PDAC) is known for its aggressive growth, and characterized by early tissue invasion metastasis with poor prognosis. Identifying prognostic markers delineating the underlying mechanisms that promote progression of PDAC are important treatment pancreatic cancer. TIP30, a newly identified tumor suppressor, appears to be involved in multiple processes during development metastasis. Here, we investigated expression TIP30 value patients. We examined...
Abstract Laryngeal squamous cell carcinoma (LSCC) is one of the most common carcinomas head and neck. Despite advances in diagnosis treatment, survival patients with LSCC has not improved past two decades. TIP30, a newly identified tumour suppressor, appears to be involved multiple processes during development. Here, we investigated involvement TIP30 chemoresistance vitro vivo . We showed that expression decreased significantly drug-selected cells (DSCs) laryngeal carcinoma. Suppressing...
Trastuzumab resistance is a common problem that impedes the effectiveness of trastuzumab in ErbB2-amplified cancers. About 70% breast cancers do not respond to (de novo resistance), and majority trastuzumab-responsive progress within 1 year (acquired resistance). Different mechanisms exist between de acquired resistance. Innate are mainly independent ErbB2 receptor activity, involves with alterations depending on activity. We previously reported H2-18, an domain I-specific antibody, which...
Hepatocellular carcinoma (HCC) is the third leading cause of death in cancer patients worldwide. Understanding molecular pathogenesis HCC recurrence and chemoresistance key to improving patients' prognosis. In this study, we report that downregulation ASPP2, a member ankyrin-repeat-containing, SH3-domain-containing, proline-rich-region-containing protein (ASPP) family, bestowed cells with stem-like properties resistance chemotherapy, including expansion side population fractions, formation...