A5086826332- Bone Metabolism and Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Pain Mechanisms and Treatments
- Renin-Angiotensin System Studies
- Sirtuins and Resveratrol in Medicine
- Natural product bioactivities and synthesis
- Bone health and treatments
- Spinal Cord Injury Research
- Neuroscience of respiration and sleep
- MicroRNA in disease regulation
- Metabolism, Diabetes, and Cancer
- Organ Transplantation Techniques and Outcomes
- Peroxisome Proliferator-Activated Receptors
- Physical Activity and Health
- Health and Lifestyle Studies
- Receptor Mechanisms and Signaling
- Adipose Tissue and Metabolism
- Magnolia and Illicium research
- Phytochemical compounds biological activities
- Congenital heart defects research
- Heart Rate Variability and Autonomic Control
- Hormonal Regulation and Hypertension
- Tracheal and airway disorders
- Obstructive Sleep Apnea Research
- Ginseng Biological Effects and Applications
People's Liberation Army 401 Hospital
2025
Chinese People's Liberation Army
2025
Shanghai Changzheng Hospital
2021-2024
Second Military Medical University
2011-2022
82th Hospital of Pla
2021-2022
Background: Sodium–glucose cotransporter-2 (SGLT2) inhibitors have been shown to decrease the adverse cardiac events and risks of cardiovascular mortality among patients with or without diabetes, which has made these drugs promising treatment options for chronic heart failure. Cardiac dysfunction is a common severe side effect induced by cancer chemotherapies, seriously affects prognosis life quality tumor patients. However, it not clear whether SGLT2 benefits in chemotherapy–related...
Imbalanced dietary patterns, sedentary behavior, and other unhealthy lifestyle behaviors are among the potentially modifiable risk factors most consistently linked to all-cause cardiovascular disease (CVD) mortality. This study aimed investigate joint association of antioxidant intakes from diet supplements behavior with CVD retrospective cohort included 16,019 adults National Health Nutrition Examination Survey (NHANES) 2007–2014. All-cause mortality was ascertained by linkage Death Index...
Background Traumatic spinal cord injury (SCI) causes severe motor dysfunction and persistent central neuropathic pain (Nep), which has not yet been effectively cured. Programmed cell death ligand-1 (PD-L1) is typically produced by cancer cells contributes to the immune-suppressive in tumor microenvironment. However, role of PD-L1 regulating inflammatory response Nep after SCI remains unclear. A growing amount researches have begun investigate effect on macrophages microglia recent years....
The imbalance between angiotensin II (Ang II) and 1-7 1-7) in the brain has been reported to contribute cardiovascular dysfunction hypertension. Exercise training (ExT) is beneficial hypertension mechanism unclear. This study was aimed determine if ExT improves via adjusting renin system centers including rostral ventrolateral medulla (RVLM). Spontaneously hypertensive rats (SHR, 8 weeks old) were subjected low-intensity or kept sedentary (Sed) for 12 weeks. Blood pressure elevation coupled...
Increased levels of serum free fatty acids (FFAs) are closely associated with microvascular dysfunction. In our previous study, a coronary dysfunction (CMD) model was successfully established via lipid infusion to increase the FFAs in mice. However, underlying mechanisms remained poorly understood. Therefore, aim present study explore mechanism FFA‑induced CMD. A CMD mouse combined heparin for 6 h concentration FFAs. Following establishment model, flow reserve (CFR), extent leukocyte...
Osteolytic bone disease is a condition of imbalanced homeostasis, characterized mainly by excessive bone-resorptive activity, which could predispose these populations, such as the old and postmenopausal women, to developing high risk skeletal fragility fracture. The nature homeostasis coordination between osteoblasts (OBs) osteoclasts (OCs). Abnormal activation (OCs) compromise constantly followed clutch osteolytic diseases, including osteoporosis, osteoarthritis, rheumatoid arthritis. Thus,...
Abstract Background The compound Danshen Dripping Pill (CDDP), which is a mixture of extracts from Radix Salviae and Panax notoginseng , patented traditional Chinese medicine that widely used in multiple countries for relieving coronary heart disease (CHD), but its pharmacological mechanism has not been fully elucidated. In this study, we screened the key pathways targets CDDP act on CHD using network pharmacology-based strategy, angiogenic activity was directly visually investigated...
Bone homeostasis has been a dynamic equilibrium between osteoclasts (OCs) and osteoblasts (OBs). However, excessive activation of OCs could disturb the bone homeostasis. As result, effective medical interventions for patients are greatly demanding. NO/guanylate cyclase (GC)/cGMP signaling cascade previously reported to regulate metabolism, GC plays significantly critical role. Vericiguat, as novel oral soluble guanylate (sGC) stimulator, firstly in 2020 treat with heart failure....
Neuropathic pain increases the risk of cardiovascular diseases including hypertension with characteristic sympathetic overactivity. The enhanced tonically active glutamatergic input to rostral ventrolateral medulla (RVLM) contributes overactivity and blood pressure (BP) in diseases. We hypothesize that neuropathic enhances inputs RVLM, which high level BP outflow. Animal model trigeminal was induced by infraorbital nerve-chronic constriction injury (ION-CCI). A significant increase renal...
Heart failure (HF) is known as the final manifestation of cardiovascular diseases. Although cellular heterogeneity heart well understood, phenotypic transformation cardiac cells in progress HF remains obscure. This study aimed to analyze through human single-cell RNA transcriptome profile. Here, cardiomyocytes (CMs), endothelial (ECs), and fibroblasts was identified by data analysis animal experiments. Abnormal myosin subunits including decrease Myosin Heavy Chain 6, Light 7 increase were...
Primary cardiac lymphoma (PCL) is a rare malignant that characteristically confined to the heart and/or pericardium. Here, case of 70-year-old male patient with complete atrioventricular block (AVB) associated PCL presented. The had 10-month history palpitation and electrocardiogram (ECG) showed AVB. Additionally, transthoracic echocardiography indicated pericardial effusion where atypical lymphoid cells were identified by pericardiocentesis. Subsequent mediastinal lymph node biopsy revealed...
Hypertension is characterized by sympathetic hyperactivity, which associated with pathophysiological progressing of hypertension. The rostral ventral lateral medulla (RVLM) plays a vital role the activity and blood pressure regulation. NAD‐dependent deacetylase Sirtuin1 (Sirt1) an organ protective regulating transcription its target genes. Sirt1 reported to show effect in circulation system such as heart vessel. However, it not clear if RVLM involved modulating central control cardiovascular...
MicroRNA (miRNA) is a family of endogenous,non-coding small RNAs molecules that function as gene regulators.It has been revealed miRNAs may play critical role in many biological processes including cell proliferation,differentiation and apoptosis.Recent studies demonstrate aberrant expression can lead to several human diseases even cancer.These tiny but potent have the anti-oncogene or oncogene.Accordingly,further study opened novel avenue diagnosis treatment cancer. Key words:...
Abstract Background Traumatic spinal cord injury (SCI) causes severe motor dysfunction and persistent central neuropathic pain (Nep) that remains uncured yet. Programmed cell death ligand-1 (PD-L1) is typically produced by cancer cells contributes to the immune-suppressive in tumor microenvironment, role of PD-L1 regulating inflammatory response Nep after SCI unclear. A growing amount research has begun investigate effect on macrophages microglia. Considering pivotal macrophages/microglia...