A5011849226- Neuroinflammation and Neurodegeneration Mechanisms
- Single-cell and spatial transcriptomics
- Immune cells in cancer
- Gut microbiota and health
- Atherosclerosis and Cardiovascular Diseases
- Moyamoya disease diagnosis and treatment
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Ferroptosis and cancer prognosis
- Diet and metabolism studies
- Gastrointestinal motility and disorders
- Congenital heart defects research
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cardiac Fibrosis and Remodeling
- Intracranial Aneurysms: Treatment and Complications
- TGF-β signaling in diseases
- Neurological Disease Mechanisms and Treatments
- Glioma Diagnosis and Treatment
- Extracellular vesicles in disease
Second Military Medical University
2019-2023
Changhai Hospital
2019-2023
The classification of microglial M1/M2 polarization in the acute phase ischemic stroke remains controversial, which has limited further advances neuroprotective strategy. To thoroughly assess phenotypes, we made middle cerebral artery occlusion model mice to simulate pathological processes from normal conditions ischemia and then early reperfusion period. temporal changes gene profiles, cell subtypes, function were comprehensively analyzed using single-cell RNA sequencing. We identified...
Astrocyte plays important roles in the pathogenesis of ischemic stroke and reperfusion injury. They intensively participate energy metabolism brain, while their heterogeneity function after remain controversial. By employing single-cell sequencing mice cortex at 12 h transient middle cerebral artery occlusion (tMCAO) comparing with similar published datasets 24h tMCAO, we uncover cellular phenotypes dynamic change astrocytes acute phase stroke. In this study, separately identified 3 major...
The latest 2021 WHO classification redefines glioblastoma (GBM) as the hierarchical reporting standard by eliminating glioblastoma, IDH-mutant and only retaining tumor entity of “glioblastoma, IDH-wild type.” Knowing that subclassification tumors based on molecular features is supposed to facilitate therapeutic choice increase response rate in cancer patients, it necessary carry out newly defined GBM. Although differentiation trajectory inference single-cell sequencing (scRNA-seq) data holds...
Heart failure (HF) is known as the final manifestation of cardiovascular diseases. Although cellular heterogeneity heart well understood, phenotypic transformation cardiac cells in progress HF remains obscure. This study aimed to analyze through human single-cell RNA transcriptome profile. Here, cardiomyocytes (CMs), endothelial (ECs), and fibroblasts was identified by data analysis animal experiments. Abnormal myosin subunits including decrease Myosin Heavy Chain 6, Light 7 increase were...
In tumor progression and epigenetic regulation, long non-coding RNA (lncRNA) necroptosis are crucial regulators. However, in glioma microenvironment, the role of necroptosis-related lncRNAs (NRLs) remains unknown. this study, RNA-seq clinical annotation patients were analyzed using Cancer Genome Atlas (TCGA) Chinese Glioma (CGGA) databases. To investigate prognosis microenvironment NRLs gliomas, we conducted a prediction model based on training cohort. The accuracy was verified verification...