A5080030367- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related molecular mechanisms research
- Single-cell and spatial transcriptomics
- Glioma Diagnosis and Treatment
Changhai Hospital
2022-2023
Second Military Medical University
2022-2023
The latest 2021 WHO classification redefines glioblastoma (GBM) as the hierarchical reporting standard by eliminating glioblastoma, IDH-mutant and only retaining tumor entity of “glioblastoma, IDH-wild type.” Knowing that subclassification tumors based on molecular features is supposed to facilitate therapeutic choice increase response rate in cancer patients, it necessary carry out newly defined GBM. Although differentiation trajectory inference single-cell sequencing (scRNA-seq) data holds...
In tumor progression and epigenetic regulation, long non-coding RNA (lncRNA) necroptosis are crucial regulators. However, in glioma microenvironment, the role of necroptosis-related lncRNAs (NRLs) remains unknown. this study, RNA-seq clinical annotation patients were analyzed using Cancer Genome Atlas (TCGA) Chinese Glioma (CGGA) databases. To investigate prognosis microenvironment NRLs gliomas, we conducted a prediction model based on training cohort. The accuracy was verified verification...