A5017422746- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Vascular Malformations Diagnosis and Treatment
- Moyamoya disease diagnosis and treatment
- Neurosurgical Procedures and Complications
- Acute Ischemic Stroke Management
- Meningioma and schwannoma management
- Intracerebral and Subarachnoid Hemorrhage Research
- Genetic Associations and Epidemiology
- Stroke Rehabilitation and Recovery
- TGF-β signaling in diseases
- Nutritional Studies and Diet
- Neuroinflammation and Neurodegeneration Mechanisms
- Hydrogen's biological and therapeutic effects
- Biochemical effects in animals
- Renin-Angiotensin System Studies
- Cancer-related Molecular Pathways
- Vascular Malformations and Hemangiomas
- Animal Genetics and Reproduction
- Antioxidant Activity and Oxidative Stress
- Dietary Effects on Health
- Medicinal Plants and Bioactive Compounds
- Molecular Biology Techniques and Applications
- Phytoestrogen effects and research
Second Military Medical University
2016-2025
Changhai Hospital
2016-2025
Fairy Lake Botanical Garden
2025
Chinese Academy of Sciences
2025
State Administration of Traditional Chinese Medicine of the People's Republic of China
2024
Jinan University
2024
Capital Medical University
2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Fujian Medical University
2024
Nanjing Medical University
2024
BackgroundThe effect of embolization the middle meningeal artery in patients with subacute or chronic subdural hematoma is uncertain.MethodsWe performed a multicenter, open-label, randomized trial China, involving symptomatic nonacute mass effect. Patients were assigned to undergo burr-hole drainage receive nonsurgical treatment at surgeon's discretion, and each group then randomly assigned, 1:1 ratio, liquid embolic material usual care. whose condition warranted craniotomy excluded. The...
Abstract Background Stroke is the second leading cause of death worldwide, and observational studies have suggested a correlation between antioxidants reduced stroke risk. However, it remains unclear whether causal relationships exist. Methods This study first performed cross-sectional association Composite Dietary Antioxidant Index (CDAI) using data from National Health Nutrition Examination Survey (NHANES) 2007–2018. Second, two-sample univariable Mendelian Randomization (MR) was to...
The added value of intravenous alteplase in reperfusing ischemic brain tissue patients undergoing endovascular treatment and directly presented to an treatment-capable hospital is uncertain. We conducted this post hoc analysis a randomized trial (DIRECT-MT [Direct Intraarterial Thrombectomy Order Revascularize Acute Ischemic Stroke Patients With Large Vessel Occlusion Efficiently Chinese Tertiary Hospitals: A Multicenter Randomized Clinical Trial]) explore the association alteplase, early...
Abstract Genome-wide association studies (GWAS) have become increasingly popular for detecting numerous loci associated with intracranial aneurysm (IA), but how these function remains unclear. In this study, we employed an integrative analytical pipeline to efficiently transform genetic associations and identify novel genes IA. Using multidimensional high-throughput data, integrated proteome-wide (PWAS), transcriptome-wide (TWAS), Mendelian randomization (MR) Bayesian co-localization...
Background While existing research has established a link between dietary habits and the incidence of intracranial aneurysms, application Mendelian randomization to explore this association remains largely uncharted.
The authors compared the contemporary perioperative procedure-related complications between coiling with stent placement and without for acutely ruptured aneurysms treated in a single center after improvement of interventional skills strategy.
Abstract Background The conventional treatments for non-acute subdural hematoma (SDH) are facing the challenge of high recurrence and progression. A novel treatment middle meningeal artery (MMA) embolization showed potential role in decreasing progression rate SDH compared to multiple cohort studies. randomized controlled trial is warranted determine effectiveness safety MMA whether superior lower symptomatic SDH. Methods This an investigator-initiated, multi-center, prospective, open-label...
Objective To investigate the effect of molecular hydrogen (H2) in a rat model subjected to optic nerve crush (ONC). Methods We tested hypothesis that after (ONC), retinal ganglion cell (RGC) could be protected by H2. Rats different groups received saline or hydrogen-rich every day for 14 days ONC. Retinas from animals each group underwent measurements hematoxylin and eosin (H&E) staining, cholera toxin beta (CTB) tracing, gamma synuclein terminal deoxynucleotidyltransferase-mediated dUTP...
Low-profiled visualized intraluminal support (LVIS) is suggested as a promising stent for complex intracranial aneurysms. However, the safety and efficacy of LVIS-assisted coiling acutely ruptured wide-necked aneurysms have not been well reported.To evaluate compared with contemporary coiling-only strategy via propensity score matching in high-volume center.A retrospective review patients who underwent LVIS placement or only from November 2013 to October 2017 was performed. Perioperative...
Background and Purpose: Recent trials showed thrombectomy alone was comparable to bridging therapy in patients with anterior circulation large vessel occlusion eligible for both intravenous alteplase endovascular thrombectomy. We performed this study examine whether site modifies the effect of before Methods: This is a prespecified subgroup analysis randomized trial evaluating risk benefit (DIRECT-MT [Direct Intra-Arterial Thrombectomy Order Revascularize AIS Patients With Large Vessel...
The elderly patients with aneurysmal subarachnoid hemorrhage (aSAH) have a greater risk of poor clinical outcome after endovascular treatment (EVT) than younger do. Hence, it is necessary to explore which factors are associated and develop predictive score specifically for aSAH receiving EVT. aim this study was validate 1-year outcomes in individual underwent In 10-year prospective study, 520 consecutive (age ≥ 60 years) EVT single center were included. factors, periprocedural, follow-up...
Objective This study aims to compare the safety and efficacy of stent-assisted coiling (SAC) with those alone (CA) for treatment ruptured tiny intracranial aneurysms. Methods We enrolled 245 patients aneurysms treated coil embolization. Patients were grouped into SAC CA groups. Baseline characteristics, periprocedural complications, clinical outcomes, angiographic results compared between two In addition, a subgroup analysis was conducted in group, regrouped low-profile visualized...
Observational studies suggest an association between blood pressure (BP) and functional outcomes in ischemic stroke patients but whether this is causal or due to confounding uncertain. We used Mendelian randomization (MR) assess causality, also explore particular classes of anti-hypertensives were associated with a better outcome after stroke.We selected genetic variants systolic diastolic BP BP-lowering genes encoding antihypertensive drugs from genome-wide (GWAS) on 757,601 individuals....
The DNA damage response helps to maintain genome integrity, suppress tumorigenesis, and mediate the effects of radiotherapy chemotherapy. Our previous studies have shown that Smad1 is upregulated activated by Atm in response, which can further bind p53 promote stabilization. Here we report another aspect interplay between Smad1. Comparison rectal tumor against paired paraneoplastic specimens analysis >500 colorectal tumors revealed was samples, attributable defects. Using MEFs as a model,...