A5011963214- Traumatic Brain Injury and Neurovascular Disturbances
- Trauma and Emergency Care Studies
- Neurosurgical Procedures and Complications
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Intracerebral and Subarachnoid Hemorrhage Research
- Spinal Fractures and Fixation Techniques
- Sepsis Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Traumatic Brain Injury Research
- Cancer-related molecular mechanisms research
- Pelvic and Acetabular Injuries
- Autopsy Techniques and Outcomes
- Cerebrospinal fluid and hydrocephalus
- Antibiotic Resistance in Bacteria
- Bacterial Infections and Vaccines
- Respiratory Support and Mechanisms
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Blood Coagulation and Thrombosis Mechanisms
- Vascular Malformations Diagnosis and Treatment
- MicroRNA in disease regulation
- Medical Imaging and Analysis
- Neuroinflammation and Neurodegeneration Mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrest and Resuscitation
Fudan University
2016-2025
Huashan Hospital
2016-2025
Shanghai Clinical Research Center
2020-2024
Shanghai Center for Brain Science and Brain-Inspired Technology
2020-2024
Capital Medical University
2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Fujian Medical University
2024
Nanjing Medical University
2024
Zhongshan Hospital
2024
Biotechnology Research Institute
2020-2022
BackgroundThe effect of embolization the middle meningeal artery in patients with subacute or chronic subdural hematoma is uncertain.MethodsWe performed a multicenter, open-label, randomized trial China, involving symptomatic nonacute mass effect. Patients were assigned to undergo burr-hole drainage receive nonsurgical treatment at surgeon's discretion, and each group then randomly assigned, 1:1 ratio, liquid embolic material usual care. whose condition warranted craniotomy excluded. The...
Coagulopathy is commonly observed after traumatic brain injury (TBI). However, it not known whether using the standard independent predictors in conjunction with coagulation tests would improve their prognostic value. We determined incidence of TBI-associated coagulopathy patients isolated TBI (iTBI), evaluated value for in-hospital mortality, and tested predictive power mortality iTBI. conducted a retrospective, observational database study on 2319 consecutive iTBI who attended Huashan...
Epigenetic modifications function in gene transcription, RNA metabolism, and other biological processes. However, multiple factors currently limit the scientific utility of epigenomic datasets generated for plants. Here, using deep-learning approaches, we developed a Smart Model Epigenetics Plants (SMEP) to predict six types modifications: DNA 5-methylcytosine (5mC) N6-methyladenosine (6mA) methylation, (m6 A) three histone modification. Using from japonica rice Nipponbare, SMEP achieved 95%...
Abstract Background The prognostic value of Neutrophil-to-Lymphocyte Ratio (NLR) for the outcome acute cervical traumatic spinal cord injury (tSCI) patients has rarely been studied by now throughout world. Methods We performed a single-center retrospective cohort study to evaluate NLR from peripheral whole blood count in with tSCI. Patients within 6 h tSCI treated between Dec 2008 and May 2018 Huashan Hospital Fudan University were enrolled. Outcomes assessed using American association...
We evaluated the effectiveness of transcutaneous electrical acupoint stimulation (TEAS) at P6 for prevention postoperative nausea and vomiting in patients undergoing supratentorial craniotomy.The study population was aged 20 to 60 years who underwent craniotomy under general anesthesia. Exclusion criteria were obesity, diabetes mellitus, a history motion sickness, vomiting, or smoking. Patients randomized into 2 groups: control. In former, electrodes placed right acupoint. controls,...
OBJECTIVE Digitally designed titanium plates are commonly used for the reconstruction of craniofacial defects, although implant exposure (referred to as failure) is one major complications. Metal hypersensitivities have been suggested possible causes failure orthopedic, intravascular, gynecological, and dental devices, yet there has no consensus on requirement allergy screening before cranioplasty. METHODS In this study, authors prospectively investigated prevalence metal hypersensitivity in...
Abstract Background Fibrinogen may play an important role in the survival of trauma patients; however, its traumatic brain injury (TBI) and correlation with disease prognosis remain poorly understood. The aims this study were to determine incidence TBI-associated hypofibrinogenemia patients TBI evaluate prognostic value fibrinogen level respect mortality clinical outcomes. Methods A total 2570 consecutive retrospectively studied. Prognostic evaluations determined using Glasgow Outcome Score...
Enterobacteriaceae are often found in the lungs of patients with severe Traumatic Brain Injury (sTBI). However, it is unknown whether these bacteria come from gut microbiota. To investigate this hypothesis, mice model sTBI was used study. After sTBI, Chao1 and Simpson index peaking at 7 d (p < 0.05). The relative abundance Acinetobacter increased to 16.26% after sTBI. chao1 microbiota peaked Three hours conditional pathogens such as Lachnoclostridium, Acinetobacter, Bacteroides Streptococcus...
Objectives: To evaluate the efficacy of traumatic brain injury management guided by intracranial pressure monitoring and to explore specific subgroups for which might be significantly associated with improved outcomes based on a classification various pathophysiologies using clinical features CT scans. Design: Retrospective observational multicenter study. Setting: Twenty-two hospitals (16 level I trauma centers six II centers) in nine provinces China. Patients: Moderate or severe patients...
Nosocomial meningitis and ventriculitis (MEN) are serious complications in neuro-critical care unit (NCCU) patients. Few data available on the risk factors mortality rates among NCCU patients with these disorders caused by multi-drug-resistant (MDR) pathogens. Our aim was to identify for MEN such pathogens in-hospital deaths critically ill neurologic evaluate impact of empirical combination antibiotic therapy (ECAT) outcomes patients.We conducted a retrospective study having nosocomial who...
Objective: Subdural hygroma (SDG) is a common complication that can occur after head trauma or secondary to decompressive craniectomy (DC). SDGs be located not only ipsilateral contralateral the side of DC, but also bilateral unilateral in patients without DC. This study investigated incidence and risk factors for different types SDG large cohort with traumatic brain injury (TBI).Methods: A retrospective was conducted involving 379 adult TBI who were admitted Huashan Hospital, Fudan...
Deferoxamine mesylate can cross the blood-brain barrier and reduce iron accumulation in nervous tissue; moreover, it has a variety of neuroprotective functions addition to complexing with ions. Such chelators are expected become new treatment option for intracerebral hemorrhage. This study evaluated effects deferoxamine on hematoma edema absorption after traumatic hemorrhage (TICH), provides clinical evidence TICH mesylate. Patients isolated TICH, confirmed by head computed tomography, were...