A5051090513- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Moyamoya disease diagnosis and treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Vascular Malformations Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Cardiovascular Health and Disease Prevention
- Aortic Disease and Treatment Approaches
- Neurosurgical Procedures and Complications
- Meningioma and schwannoma management
- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Intracerebral and Subarachnoid Hemorrhage Research
- Posttraumatic Stress Disorder Research
- Traumatic Brain Injury Research
- Coronary Interventions and Diagnostics
- Atherosclerosis and Cardiovascular Diseases
- IgG4-Related and Inflammatory Diseases
- Cardiovascular Disease and Adiposity
- Venous Thromboembolism Diagnosis and Management
- Cerebrospinal fluid and hydrocephalus
- Spinal Cord Injury Research
- interferon and immune responses
- Nasal Surgery and Airway Studies
- Extracellular vesicles in disease
Renji Hospital
2015-2025
Shanghai Jiao Tong University
2016-2025
Soochow University
2025
First Affiliated Hospital of Soochow University
2025
Capital Medical University
2023-2025
Beijing Anzhen Hospital
2023-2025
Nanjing Agricultural University
2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Fujian Medical University
2024
Nanjing Medical University
2024
<h3>Importance</h3> In-stent restenosis (ISR) is the primary reason for stroke recurrence after intracranial stenting in patients who were treated with a standard bare-metal stent (BMS). Whether drug-eluting (DES) could reduce risk of ISR atherosclerotic stenosis (ICAS) remains unclear. <h3>Objective</h3> To investigate whether DES can and symptomatic high-grade ICAS. <h3>Design, Settings, Participants</h3> A prospective, multicenter, open-label randomized clinical trial blinded outcome...
BackgroundThe effect of embolization the middle meningeal artery in patients with subacute or chronic subdural hematoma is uncertain.MethodsWe performed a multicenter, open-label, randomized trial China, involving symptomatic nonacute mass effect. Patients were assigned to undergo burr-hole drainage receive nonsurgical treatment at surgeon's discretion, and each group then randomly assigned, 1:1 ratio, liquid embolic material usual care. whose condition warranted craniotomy excluded. The...
<h3>BACKGROUND AND PURPOSE:</h3> Although flow diverters have been reported with favorable clinical and angiographic outcomes in various literatures, randomized trials determining their true effectiveness safety are still lack. The Parent Artery Reconstruction for Large or Giant Cerebral Aneurysms Using the Tubridge Flow Diverter (PARAT) trial was designed to evaluate efficacy of diverter treatment large giant aneurysms comparison Enterprise stent-assisted coiling. <h3>MATERIALS...
The goal of this study was to investigate the relationship between resting-state functional connectivity and severity post-traumatic stress disorder (PTSD) symptoms in 15 people who developed PTSD following recent trauma. Fifteen participants experienced acute traumatic events underwent a 7.3-min resting magnetic resonance imaging scan within 2 days post-event. All patients were diagnosed with 1 6 months after Brain areas which activity correlated that posterior cingulate cortex (PCC)...
Symptomatic internal carotid artery (ICA) occlusion with hemodynamic impairment remains a dismal disease when untreated. In this prospective, single-center, controlled study, we investigated the feasibility, safety, and long-term outcome of stenting by endovascular recanalization for patients chronic ICA occlusion. Forty symptomatic chronically occluded were assigned to receive (group A, n = 18) or conservative management B, 22). The primary end point was 100% complete at 60 minutes,...
To assess fast three-dimensional (3D) black-blood (BB) magnetic resonance (MR) imaging as a noninvasive alternative to intraarterial digital subtraction angiography (DSA) at quantifying moderate severe carotid artery atherosclerotic disease.Local ethics committee approval and written informed patient consent were obtained for this study. Sixty-five arteries from 52 patients with least 50% stenosis underwent 3D BB MR DSA. Quantitative measurements, including stenosis, lesion length, the...
The Pipeline Embolization Device (PED, Covidien/Medtronic) is widely used to treat intracranial aneurysms. This PED in China post-market multi-center registry study (PLUS) investigated safety and effectiveness of the for aneurysms Chinese population.This was a panoramic, consecutive, real-world cohort study. Patients treated with or without coils between November 2014 October 2019 at 14 centers were included, those by parent vessel occlusion other stents excluded. Study outcomes included...
<h3>BACKGROUND AND PURPOSE:</h3> Fractional flow measured on 3D-TOF-MRA was proposed to quantify cerebral hemodynamic changes in patients with artery stenosis. We investigated the association between fractional and perfusion symptomatic MCA <h3>MATERIALS METHODS:</h3> This prospective study approved by institutional review board, all participants provided written informed consent. From June 2015 May 2018, four hundred twenty-nine intracranial arterial stenosis were consecutively recruited...
Endovascular mechanical thrombectomy (EMT) is an effective treatment for acute ischemic stroke and identifying the precise thrombus size remains key to a successful EMT. However, no imaging modality has been able provide this information simultaneously efficiently in emergency setting. The present study introduces novel technique named dual-channel bolus contrast injection (Dc-BCI) determining location during In vitro study, Dc-BCI demonstrated accurate projection of size, as actual diameter...
The postoperative health status of elderly patients has a substantial impact on both the individuals themselves and their families, this became more pronounced with advancing age. aim study was to identify risk factors that can predict aged 80 over after major abdominal surgery establish nomogram model. We conducted retrospective (aged 80+) who underwent at First Affiliated Hospital Soochow University from January 2017 June 2023. Least absolute shrinkage selection operator (lasso) regression...
Background The optimal selection of stent size remains uncertain. This study evaluated the impact diameter on in-stent stenosis (ISS) after interventional therapy through a subgroup analysis Intracranial Aneurysms Managed by Parent Artery Reconstruction Using Tubridge Flow Diverter (IMPACT) trial. Methods prospective, multicenter included patients treated with (TFD) at 14 centers between December 16, 2019 and October 26, 2022. primary outcome was incidence ISS 12-month follow-up. We analyzed...
Isocitrate dehydrogenase wild-type (WT) glioblastoma (GBM) accounts for 90% of all GBMs, yet only 27% isocitrate WT-GBMs have p53 mutations. However, the tumor surveillance function WT-p53 in GBM is subverted by mechanisms that are not fully understood.We investigated proteolytic inactivation asparaginyl endopeptidase (AEP) and its effects on progression cancer cells, murine models, patients' specimens using biochemical functional assays. The sera healthy donors (n = 48) patients 20) were...
It remains unclear whether white matter (WM) changes found in post-traumatic stress disorder (PTSD) patients are stress-induced or precursors for vulnerability. The current study aimed to identify susceptibility factors relating the development of PTSD and examine ability these predict course longitudinal PTSD. Sixty two victims who had experienced traffic accidents underwent diffusion tensor imaging using a 3.0T MRI system within 2 days after their accidents. Of these, 21 were diagnosed...
Objectives The aim of this study was to compare complications and outcomes between intracranial aneurysms treated with the Pipeline embolisation device (PED) alone or PED combined coiling for different-sized aneurysms. Method Patients by were collected from in China postmarket multicentre registry study. We performed a propensity match analysis efficacy safety treatment, then organised into three groups based on their size: small (≤7 mm), medium (≤15 mm >7 mm) large/giant (>15 mm)....
Intracranial fusiform aneurysms are less common than saccular aneurysms, but associated with higher mortality and morbidity. We conducted this study to determine the safety efficacy of pipeline embolization device (PED) treat intracranial aneurysms. This was a multicenter, retrospective, observational study. Data for came from PLUS 2014 2019 across 14 centers in China. Univariate multivariable logistic regression analyses were performed evaluate predictors occlusion rate complication. A...
It is critical to accurately predict the rupture risk of an intracranial aneurysm (IA) for timely and appropriate treatment because fatality rate after 50%. Existing methods relying on morphological features (e.g., height-width ratio) measured manually by neuroradiologists are labor intensive have limited use assessment. Therefore, we propose end-to-end deep-learning method, called TransIAR net, automatically learn from 3D computed tomography angiography (CTA) data status IA rupture. We...