A5101662807- Cerebrovascular and Carotid Artery Diseases
- Intracranial Aneurysms: Treatment and Complications
- Cardiovascular Health and Disease Prevention
- Acute Ischemic Stroke Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Environmental Quality and Pollution
- Moyamoya disease diagnosis and treatment
- Water Quality Monitoring and Analysis
- Advanced MRI Techniques and Applications
- Arsenic contamination and mitigation
- Microtubule and mitosis dynamics
- Fluoride Effects and Removal
- Liver Disease Diagnosis and Treatment
- MRI in cancer diagnosis
- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Cardiovascular Disease and Adiposity
- Brain Tumor Detection and Classification
- Heme Oxygenase-1 and Carbon Monoxide
- interferon and immune responses
- CAR-T cell therapy research
- Renal cell carcinoma treatment
- Agriculture, Soil, Plant Science
- Intracerebral and Subarachnoid Hemorrhage Research
Shanghai Jiao Tong University
2013-2024
Renji Hospital
2015-2024
Wuhan University
2019
Renmin Hospital of Wuhan University
2019
Xinjiang Production and Construction Corps
2017-2018
Shihezi University
2017-2018
Huazhong University of Science and Technology
2014-2015
Xuzhou Medical College
2015
Xuzhou Central Hospital
2015
Xinjiang Uygur Autonomous Region Disease Prevention and Control Center
2013-2014
Diabetic patients are more susceptible to renal ischemia/reperfusion (I/R) injury (RI/RI) and have a poor prognosis, but the underlying mechanism remains unclear. The present study aimed examine whether diabetes could worsen acute kidney induced by I/R in rats clarify its mechanism. Control streptozotocin-induced diabetic were subjected 45 min pedicle occlusion followed 24 h reperfusion. Tert-butylhydroquinone (TBHQ, 16.7 mg/kg) was administrated intraperitoneally 3 times at intervals of 8...
Background: Intracranial atherosclerotic disease (ICAD) tends to affect multiple arterial segments, and previous studies rarely performed a comprehensive plaque analysis of the entire circle Willis for evaluation recurrent stroke risk. We aimed investigate features ICAD on 3D magnetic resonance vessel wall imaging (MR-VWI) their relationships with acute stroke. Methods: Patients either ischemic (within 4 weeks after stroke) or chronic (after 3 months due intracranial underwent...
Objective: To compare various models of diffusion-weighted imaging including monoexponential apparent diffusion coefficient (ADC), biexponential (fast [D f ], slow s and fraction fast diffusion), stretched-exponential (distributed anomalous exponent term [α]), kurtosis (mean diffusivity mean [MK]) in the differentiation renal solid masses.Materials Methods: A total 81 patients (56 men 25 women; age, 57 years; age range, 30-69 years) with 18 benign 63 malignant lesions were imaged using 3T...
Background Type 2 diabetes mellitus (T2DM) has shown to be associated with carotid plaque vulnerability. However, the impact of T2DM on intracranial artery atherosclerosis is not well‐understood. Purpose To evaluate association and glycemic control atherosclerotic characteristics identified by three‐dimensional contrast enhanced MR vessel wall imaging in patients after acute ischemic stroke. Study Prospective. Population Two hundred eighty‐eight symptomatic stroke due plaque. Field...
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which causes coronavirus disease-2019 (COVID-19), interacts with the host cell receptor angiotensin-converting enzyme 2 (hACE2) via its spike 1 protein during infection. After virus sequence was published, we identified two potent antibodies against SARS-CoV-2 binding domain (RBD) from antibody libraries using a phage-to-yeast (PtY) display platform in only 10 days. Our lead JMB2002, now Phase clinical trial (ChiCTR2100042150),...
<h3>BACKGROUND AND PURPOSE:</h3> Intracranial plaque enhancement (IPE) identified by contrast-enhanced vessel wall MR imaging (VW-MR imaging) is an emerging marker of instability related to stroke risk, but there was no standardized timing for postcontrast acquisition. We aim explore the optimal using multiphase VW-MR and test its performance in differentiating culprit nonculprit lesions. <h3>MATERIALS METHODS:</h3> Patients with acute ischemic due intracranial were prospectively recruited...
Background Intracranial aneurysms (IAs) are common in the population and current imaging-based rupture risk assessment needs to be refined. We aimed use four-dimensional CT angiography (4D-CTA) investigate associations of irregular pulsation IAs with conventional factors estimated risk. Methods One hundred five patients 117 asymptomatic underwent 4D-CTA. Geometric morphologic parameters were measured presence (defined as a temporary focal protuberance ≥1 mm on more than three successive...
The increasingly demonstrated association of wall enhancement (WE) measured by vascular imaging with the instability/rupture intracranial aneurysms (IAs) implies significance investigating transport and accumulation blood substances [e.g., low-density lipoprotein (LDL), (a)] related to WE in IAs. In present study, we perform numerical simulations explore relationships between distribution/severity LDL deposition on lumen surface morphological characteristics aneurysm its adjacent arteries as...
The fluoride (F) content of groundwater is high in Kuitun, Xinjiang, China, and the amount F soil plants severely exceeds limit after irrigation. This study designed a potted plant experiment at different concentrations irrigation water to investigate migration transformation pattern water–soil–plant system. Three kinds green vegetables with metabolism were selected. Different NaF solutions also prepared simulate farmland Kuitun. After irrigated concentrations, contents water-soluble state...
Irregular pulsation of aneurysmal wall detected by four-dimensional CT angiography (4D-CTA) has been described as a novel imaging feature aneurysm vulnerability. Our study aimed to investigate whether irregular is associated with symptomatic and ruptured intracranial aneurysms (IAs).This retrospective included consecutive patients IAs who underwent 4D-CTA from January 2018 July 2021. were categorized asymptomatic, or ruptured. The presence (defined temporary focal protuberance ≥1 mm on more...
Fluoride (F) pollution is a serious environmental problem in some areas of China, but it has yet to be reported soil–water–plant system Shihezi, Xinjiang. This study was undertaken investigate the distribution and migration rule F soil, water, plants, evaluate soil. Results showed that average concentration total (T-F) topsoil northwest, north, southeast Shihezi higher than national T-F (478 mg/kg), while lower southwest. The highest contents soil profile were detected depth 20 cm. content...
Background: We sought to determine if the morphological and compositional features of chronic internal carotid artery occlusion (CICAO), as assessed by MR vessel wall imaging (MR-VWI), initially predict successful endovascular recanalization. Methods: Consecutive patients with CICAO scheduled for recanalization were recruited. MR-VWI was performed within 1 week prior surgery evaluating following features: proximal stump morphology, extent occlusion, collapse, arterial tortuosity, presence...
Background Unruptured intracranial aneurysms (IAs) that become symptomatic have been associated with instability. Objective To investigate the relationship between irregular pulsation on four-dimensional CT angiography (4D-CTA) and aneurysm wall enhancement (AWE) vessel MRI (VW-MRI), to evaluate their ability identify IAs. Methods This retrospective study included consecutive patients IAs who underwent 4D-CTA VW-MRI March 2018 May 2023. were categorized as asymptomatic symptomatic. The...
Radiofrequency ablation (RFA) has a low rate of complication and is one the most effective minimally invasive techniques for treatment liver tumors. However, number complications may occur in rare cases, including bronchobiliary fistula, hollow viscera perforation, diaphragmatic perforation hernia. The present study reports case hepatic abscess with hepatobronchial fistula following RFA hepatocellular carcinoma; this led to severe lung infection, respiratory failure mortality. report aims...
Microstructural changes of lupus nephritis (LN) kidney such as inflammatory cell infiltration or fibrosis could influence water molecular movement diffusion, which indicates that diffusion-weighted imaging (DWI) may become a valuable tool in evaluation this disease.To explore whether multiparameter (mDWI) contribute to characterize pathological patterns LN patients.Retrospective.Twenty-two patients with LN.Multi-b value DWI was performed 3.0 T scanner.Apparent diffusion coefficient (ADC)m ,...
Intracranial aneurysms are relatively common life-threatening diseases, and assessing aneurysm rupture risk identifying the associated factors is essential. Parameters such as Oscillatory Shear Index, Pressure Loss Coefficient, Wall Stress reliable indicators of intracranial development risk, but surface irregular pulsation has also received attention in assessment.
Background: Ischemia of the cephalad lobes (70% liver mass) is a frequently employed mouse hepatic ischemia/reperfusion (I/R) model that does not involve outflow occlusion. This produces results with relatively large variances. Materials and Methods: A novel ischemia left lateral lobe (35% involves temporarily occluding blood supply to expel followed by occlusion both inflow lobe, was developed. Mice in 35% (novel) 70% (existing) groups were subjected I/R injury, biochemical histological...
Bicyclol [4,4′-dimethoxy-5,6,5′,6′-bis(methylenedioxy)-2-hydroxy-methyl-2′-methoxycarbonyl biphenyl] is a synthetic hepatoprotectant widely used in clinical practice, but resistance to this treatment often observed. We found that the hepatoprotective effect of bicyclol was greatly compromised female and castrated male mice. This study dissect molecular basis behind sex difference, which might underlie uncertainty. compared bicyclol-induced hepatoprotection between mice using acute liver...
Recent studies have suggested that irregular pulsation of intracranial aneurysm during the cardiac cycle may be potentially associated with rupture risk. However, there is a lack quantification method for pulsations. This study aims to quantify pulsations by displacement and strain distribution surface using four-dimensional CT angiographic image data. Four-dimensional angiography was performed in 8 patients. The data divided into approximately 20 phases, were detected four aneurysms visual...
Both aneurysm wall enhancement (AWE) and irregular pulsation have been suggested as potential candidates for intracranial aneurysms (IAs) instability. However, no studies compared AWE evaluation symptoms in unruptured IAs. By using vessel MRI four-dimensional computed tomography angiography, we found combination of improve the diagnostic efficiency symptomatic with or alone. Further longitudinal are needed to validate role two imaging markers predicting growth rupture.