A5050974013- Dementia and Cognitive Impairment Research
- Cerebrovascular and Carotid Artery Diseases
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Acute Ischemic Stroke Management
- Advanced MRI Techniques and Applications
- Cardiovascular Health and Disease Prevention
- Functional Brain Connectivity Studies
- Gestational Diabetes Research and Management
- China's Ethnic Minorities and Relations
- Neurological Disorders and Treatments
- LGBTQ Health, Identity, and Policy
- Folate and B Vitamins Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cultural Industries and Urban Development
- Cardiovascular Health and Risk Factors
- Neonatal Respiratory Health Research
- Intracerebral and Subarachnoid Hemorrhage Research
- HIV/AIDS Research and Interventions
- Ethics in Clinical Research
- Health Systems, Economic Evaluations, Quality of Life
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Innovations in Medical Education
- Inflammation biomarkers and pathways
Renji Hospital
2006-2025
Shanghai Jiao Tong University
2010-2025
Huazhong University of Science and Technology
2017-2025
Shanghai Chest Hospital
2025
Union Hospital
2022-2025
Wuhan Children's Hospital
2023-2024
Jiangmen Central Hospital
2022
Dalian Medical University
2022
Chongqing Medical University
2022
Second Affiliated Hospital of Chongqing Medical University
2022
Background Internet addiction disorder (IAD) is currently becoming a serious mental health issue around the globe. Previous studies regarding IAD were mainly focused on associated psychological examinations. However, there are few brain structure and function about IAD. In this study, we used diffusion tensor imaging (DTI) to investigate white matter integrity in adolescents with Methodology/Principal Findings Seventeen subjects sixteen healthy controls without participated study. Whole...
Abstract Purpose: This study aimed to assess the antitumor activity and safety of neoadjuvant chemotherapy combined with PD-1 inhibitor camrelizumab in patients locally advanced head neck squamous cell carcinoma (HNSCC). Patients Methods: In this single-center, single-arm, phase 2 trial, resectable stage III–IVB HNSCC received [albumin-bound paclitaxel 260 mg/m2 (or docetaxel 75 mg/m2) plus cisplatin mg/m2] 200 mg on day 1 each 21-day cycle for three cycles, followed by surgery, adjuvant...
Delayed recall of words in a verbal learning test is sensitive measure for the diagnosis amnestic mild cognitive impairment (aMCI) and early Alzheimer’s disease (AD). The relative validity different retention intervals delayed has not been well characterized. Using Auditory Verbal Learning Test–Huashan version, we compared differentiating value short-term (AVL-SR, that is, 3- to 5-minute delay time) long-term (AVL-LR, 20-minute distinguishing patients with aMCI (n = 897) AD 530) from healthy...
Objective The Trail making test (TMT) is culture-loaded because of reliance on the Latin alphabet, limiting its application in Eastern populations. Shape Test (STT) has been developed as a new variant. This study to examine applicability STT senile Chinese population and evaluate potential advantages disadvantages. Method A total 2470 participants were recruited, including 1151 cognitively normal control (NC), 898 amnestic mild cognitive impairment (aMCI), 421 Alzheimer disease (AD)...
<b><i>Background:</i></b> To establish a prospective cohort to enumerate the prevalence, incidence and risk factors for dementia mild cognitive impairment (MCI) among residents aged ≥60 in an urban community of Shanghai, China. <b><i>Methods:</i></b> Participants received clinical evaluations including physical measurements, demographic lifestyle questionnaires, neurologic examinations, neuropsychological testing. Urine blood samples were...
Alzheimer disease (AD) represents a genetically heterogeneous entity. To elucidate neuropathologic features of autosomal dominant AD ([ADAD] due to PSEN1 , APP or PSEN2 mutations), we compared hallmark pathologic findings in 60 cases ADAD and 120 sporadic matched for sex, race, ethnicity, duration. Greater degrees neuritic plaque neurofibrillary tangle formation cerebral amyloid angiopathy (CAA) were found (p values < 0.01). Moderate severe CAA was more prevalent (63.3% vs. 39.2%, p =...
High Resolution (HR) medical images provide rich anatomical structure details to facilitate early and accurate diagnosis. In magnetic resonance imaging (MRI), restricted by hardware capacity, scan time, patient cooperation ability, isotropic 3-dimensional (3D) HR image acquisition typically requests long time and, results in small spatial coverage low signal-to-noise ratio (SNR). Recent studies showed that, with deep convolutional neural networks, MR could be recovered from low-resolution...
Alzheimer's disease (AD) incidence is disproportionately high in African Americans, yet, recruitment of this community to AD clinical trials challenging.We compared 47 Americans and 78 whites their willingness enroll a hypothetical preclinical trial examined barriers facilitators decision making.African American race (OR = 0.45; 95% CI, 0.22-0.93) score on the research attitude questionnaire 1.12; 1.04-1.22) were independently associated with participate. rated study risks, requirement...
Prior studies indicate psychiatric symptoms such as depression, apathy and anxiety are risk factors for or prodromal of incipient Alzheimer's disease. The study persons at 50% inheriting autosomal dominant disease mutations allows characterization these before progressive decline in a population destined to develop illness. We sought characterize early behavioural features carriers mutations. Two hundred sixty-one unaware their mutation status enrolled the Dominantly Inherited Alzheimer...
Brain microstructural alterations possibly occur in the normal-appearing white matter (NAWM) and grey of small vessel disease (SVD) patients, may contribute to cognitive impairment. The aim this study was explore related deep nuclei SVD patients using magnetic resonance (MR) quantitative susceptibility mapping (QSM). 170 including 103 vascular mild impairment (VaMCI) 67 no (NCI), 21 healthy control (HC) subjects were included, all underwent a whole-brain QSM scanning. Using atlas,...
<h3>Importance</h3> Although cerebral amyloid angiopathy (CAA) has important clinical implications, our understanding of it and ability to diagnose are limited. <h3>Objective</h3> To determine pathological correlates factors identifiable during life that predict the presence severe CAA in persons with pathologically confirmed Alzheimer disease (AD). <h3>Design, Setting, Participants</h3> We compared demographic variables at earliest visit which participants were found have cognitive...
Background: Intracranial atherosclerotic disease (ICAD) tends to affect multiple arterial segments, and previous studies rarely performed a comprehensive plaque analysis of the entire circle Willis for evaluation recurrent stroke risk. We aimed investigate features ICAD on 3D magnetic resonance vessel wall imaging (MR-VWI) their relationships with acute stroke. Methods: Patients either ischemic (within 4 weeks after stroke) or chronic (after 3 months due intracranial underwent...
Performance on the Montreal Cognitive Assessment (MoCA) has been demonstrated to be dependent educational level. The purpose of this study was identify how best adjust MoCA scores and items most sensitive cognitive decline in incipient Alzheimer's disease (AD) a Spanish-speaking population with varied levels education.We analyzed data from 50 participants. We examined pattern diagnosis-adjusted residuals relation education compared four alternative score adjustments using bootstrap sampling....
To describe the level and risk factors for suicidal behaviors in Chinese men who have sex with (MSM). A total of 807 MSM were recruited using a respondent-driven sampling method from Anshan, Benxi, Dandong, Shenyang cities northeastern China. had lifetime prevalences suicide ideation (18.3 %), plan (8.7 %) attempt (4.6 that about 2.8, 5.8 times greater than male adults general population The any psychiatric disorders 4–7 more likely to think about, or those no disorder, there was clear...
Gaining more information about the reciprocal associations between different biomarkers within ATN (Amyloid/Tau/Neurodegeneration) framework across Alzheimer's disease (AD) spectrum is clinically relevant. We aimed to conduct a comprehensive head-to-head comparison of plasma and positron emission tomography (PET) in subjects with cognitive complaints.
<i>Background/Aims:</i> To investigate whether diffusion tensor imaging (DTI) is more sensitive than conventional MRI at detecting cognitive deterioration in patients with subcortical ischemic vascular disease (SIVD). <i>Methods:</i> Forty-two SIVD had a diagnosis of no impairment (NCI), impairment/no dementia or (VaD). Whole-brain DTI histography and routine were performed on these participants. <i>Results:</i> There significant differences between...
Aim: Efficacy and safety of Cistanche tubulosa glycoside capsules (CTG capsule, Memoregain ® ) for treating Alzheimer’s disease (AD) were studied. Methods: A total 18 patients with AD administered 48 weeks assessed drug efficacy by Disease Assessment Scale–cognitive subscale (ADAS-cog), Mini-Mental State Examination (MMSE), Activities Daily Living (ADLs), Blessed Behavioral Scale, Clinical Global Impression (CGI) scales. Results: The MMSE score was 14.78 ± 2.51 at baseline 14.06 4.26 study...
To evaluate the predictive value of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte (PLR) in peripheral blood for assessing treatment response to chemoimmunotherapy primary advanced hypopharyngeal squamous cell carcinoma (HPSCC), we retrospectively reviewed medical records patients treated with neoadjuvant taxane-platinum (TP) chemotherapy plus an anti-programmed death-1 (PD-1) inhibitor at Wuhan Union Hospital from Jan 2020 Dec 2022. We collected data on absolute neutrophil,...