A5102931520- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Environmental Quality and Pollution
- Coastal and Marine Management
- Environmental Changes in China
- Water Quality and Pollution Assessment
- Vehicle emissions and performance
- Coral and Marine Ecosystems Studies
- Parkinson's Disease Mechanisms and Treatments
- Heavy metals in environment
- Air Quality and Health Impacts
- Indoor Air Quality and Microbial Exposure
- Marine and fisheries research
- RNA Research and Splicing
- Industrial Technology and Control Systems
- Electric and Hybrid Vehicle Technologies
- Coastal and Marine Dynamics
- Stroke Rehabilitation and Recovery
- Plant Pathogens and Fungal Diseases
- Cancer, Hypoxia, and Metabolism
- Neurological Disease Mechanisms and Treatments
- Environmental and Agricultural Sciences
- Schizophrenia research and treatment
- Coastal wetland ecosystem dynamics
- RNA regulation and disease
Fujian Institute of Oceanography
2012-2025
Xiamen University
2025
Ministry of Natural Resources
2019-2025
Fudan University
2016-2025
Huashan Hospital
2016-2025
Sichuan University
2023-2025
Ministry of Education of the People's Republic of China
2022-2024
Xi'an Jiaotong University
2024
Zhejiang University
2020-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Biodegradable piezoelectric devices hold great promise in on-demand transient bioelectronics. Existing biomaterials, however, remain obstacles to the development of such due difficulties large-scale crystal orientation alignment and weak piezoelectricity. Here, we present a strategy for synthesis optimally orientated, self-aligned γ-glycine/polyvinyl alcohol (γ-glycine/PVA) films via an ultrasound-assisted process, guided by density functional theory. The first-principles calculations reveal...
Alzheimer’s disease (AD) is a leading cause of mortality among the elderly. We performed whole-genome sequencing study AD in Chinese population. In addition to variants identified or around APOE locus (sentinel variant rs73052335, P = 1.44 × 10 −14 ), two common variants, GCH1 (rs72713460, 4.36 −5 ) and KCNJ15 (rs928771, 3.60 −6 were further verified for their possible risk effects three small non-Asian cohorts. Genotype–phenotype analysis showed that rs928771 affects onset age AD, with...
Clinical approaches for cancer therapy face several interrelated challenges involving inefficient drug delivery, potential adverse side effects, and inconvenience. Here, we present an integrated wearable flexible ultrasound microneedle patch (wf-UMP) that serves as a portable platform convenient, efficient, minimally invasive therapy. The wf-UMP adopts all-in-one bioelectronic concept, which integrates stretchable lead-free transducer array acoustic emission, bioadhesive hydrogel elastomer...
Chinese version of Montreal Cognitive Assessment Basic for discrimination among different severities Alzheimer's disease Lin Huang,1 Ke-Liang Chen,1 Bi-Ying Lin,1 Le Tang,1 Qian-Hua Zhao,1 Ying-Ru Lv,2,* Qi-Hao Guo1,* 1Department Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China; 2Department Radiology, China *These authors contributed equally to this work Objectives: To find out whether the (MoCA-BC) and its subtests could be applied in cognitively...
Neuropathic pain is a chronic disease that severely afflicts the life and emotional status of patients, but currently available treatments are often ineffective. Novel therapeutic targets for alleviation neuropathic urgently needed. Rhodojaponin VI, grayanotoxin from Rhododendron molle, showed remarkable antinociceptive efficacy in models pain, its biotargets mechanisms unknown. Given reversible action rhodojaponin VI narrow range over which structure can be modified, we perforwmed thermal...
Previous studies demonstrated that plasma neurofilament light chain (NFL) played important predictive roles in disease progression and neurodegeneration the preclinical phase of familial Alzheimer's (AD).However, whether NFL has same sporadic AD is still unclear.In this study, 243 cognitively normal (CN) participants from ADNI database were divided into two subgroups (CN-and CN+) according to CSF Aβ or AV45-PET.Associations baseline concentrations rate change with longitudinal data on other...
Heavy metal contamination of aquatic environment has attracted global attention owing to its abundance, persistence, and environmental toxicity, especially in developing countries like Bangladesh. Five heavy metals, namely chromium (Cr), copper (Cu), nickel (Ni), lead (Pb) zinc (Zn) were investigated surface core sediments the Karnaphuli River (KR) estuary Chittagong, Bangladesh, order reveal history estuarine response catastrophic events human activities. The sediment was predominantly...
This study was conducted to compare predictive power of Auditory verbal learning test (AVLT) recall measures for Alzheimer's disease (AD) conversion and normal cognition (NC) reversion from mild cognitive impairment (MCI). A total 262 amnestic MCI patients were followed up longitudinally, who then classified into different groups based on clinical outcomes. Demographic information AVLT scores at baseline compared among these groups. Receiver operating characteristic (ROC) curves constructed...
The relationship between mild behavioral impairment (MBI) and Alzheimer's disease (AD) is intricate still not well investigated. purpose of the study to examine roles AD imaging pathologies in modulating associations MBI with cognitive impairments. We analyzed 1129 participants (563 [49.86%] female), who had measures Neuropsychiatric Inventory Questionnaire (NPI-Q), cognition, amyloid PET biomarkers from Neuroimaging Initiative (ADNI). assess longitudinal neuropathological clinical...
Gaining more information about the reciprocal associations between different biomarkers within ATN (Amyloid/Tau/Neurodegeneration) framework across Alzheimer's disease (AD) spectrum is clinically relevant. We aimed to conduct a comprehensive head-to-head comparison of plasma and positron emission tomography (PET) in subjects with cognitive complaints.
Mating-type genes are central to sexual reproduction in ascomycete fungi and result the establishment of reproductive barriers. Together with hybridization, they both play important roles evolution fungi. Recently, potential hybridization events MAT were separately found Elata Clade Morchella. Herein, we characterized MAT1-1-1 MAT1-2-1 twenty-two species Esculenta Clade, another main group genus Morchella, proved heterothallism be predominant mating strategy among tested. Ascospores these...
Previous studies reported the value of blood-based biomarkers in predicting Alzheimer disease (AD) progression among individuals with different stages. However, evidence regarding these markers those amnestic mild cognitive impairment (aMCI) is insufficient.A cohort 251 aMCI were followed for up to 8 years. Baseline blood measured on a single-molecule array platform. Multipoint clinical diagnosis and domain-specific functions assessed investigate longitudinal relationship between AD...
<p>St. Martin's Island was declared an ecologically critical area of Bangladesh in 1999, but this has had limited effect on the conservation island's natural coral resources, which a thriving tourism industry and local inhabitants depend. The introduction entrance fee can benefit management island, research amount that tourists are willing to pay is absent. objective paper determine appropriate would be (WTP) for visiting St. using contingent valuation method questionnaire surveys...
To explore the effect of APOE polymorphisms on patients with cognitive impairments in The Chinese Han population.A total 1027 cases Alzheimer's disease (AD), 40 vascular dementia (VaD), 28 behavioral variant frontotemporal (bvFTD), 54 semantic (SD), 44 Lewy bodies (DLB), 583 mild impairment (MCI), and 32 no (VCIND) were recruited consecutively from memory disorders clinics Huashan Hospital between January 2010 December 2014. 1149 cognitively normal controls community epidemiologic...
Whether dementia with Lewy bodies (DLB) and Parkinson's disease (PD) (PDD) represent the same disease, distinct entities, or conditions within spectrum remains controversial.The objective of this study was to provide new insight into debate by separately identifying disease-specific metabolic patterns comparing them each other previously established PD-related pattern (PDRP).Patients DLB (n = 67), patients PDD 50), healthy control subjects (HCs; n 15) brain 18 F-fluorodeoxyglucose positron...