A5009368703- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Drug Transport and Resistance Mechanisms
- Magnetic Properties of Alloys
- Heme Oxygenase-1 and Carbon Monoxide
- Rare-earth and actinide compounds
- Advanced Drug Delivery Systems
- Pancreatic function and diabetes
- Neonatal Health and Biochemistry
- Autophagy in Disease and Therapy
- Hydrogen Storage and Materials
- interferon and immune responses
- Cancer, Hypoxia, and Metabolism
- Cannabis and Cannabinoid Research
- Pharmacological Effects and Toxicity Studies
- Drug Solubulity and Delivery Systems
- Inflammasome and immune disorders
- Metallurgical and Alloy Processes
- Electrospun Nanofibers in Biomedical Applications
- Wound Healing and Treatments
- Tissue Engineering and Regenerative Medicine
- Extracellular vesicles in disease
- Epigenetics and DNA Methylation
- Immune cells in cancer
Wenzhou Medical University
2018-2025
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2020-2025
Guilin University of Electronic Technology
2013-2024
Chinese PLA General Hospital
2024
Chinese People's Liberation Army
2024
Hubei University of Science and Technology
2015-2024
Southern Medical University
2024
Zhejiang Institute of Communications
2023
Xijing Hospital
2022
Air Force Medical University
2022
Abstract Osteoarthritis (OA) is a chronic inflammatory disease characterized by cartilage destruction, synovitis, and osteophyte formation. Disease‐modifying treatments for OA are currently lacking. Because inflammation mediated an imbalance of M1/M2 macrophages in the synovial cavities contributes to progression, regulating M1 M2 polarization can be potential therapeutic strategy. Basing on inherent immune mechanism pathological environment OA, immunoglobulin G‐conjugated bilirubin/JPH203...
Introduction Diabetic nephropathy (DN), a major complication of diabetes, presents with poor clinical outcomes and affects patients throughout their lifetime. α-Methyltryptophan (α-MT) is blocker the amino acid transporter. SLC6A14 also an inhibitor indoleamine 2,3-dioxygenase-1 (IDO1). Methods In this study, we employed nuclear magnetic resonance-based metabolomic approach to investigate therapeutic effects α-MT in db/db mouse model DN explore underlying molecular mechanisms. Results The...
An effective steady-state redox balance is maintained in cancer cells, allowing for protection against oxidative stress and thereby enhancing cell proliferation tumor growth. Disruption of this would increase the cellular content reactive oxygen species (ROS) potentiate stress-induced death thus representing an strategy treatment. Glutathione (GSH) a major reducing agent, its levels are determined at least partly by availability cysteine via xCT (SLC7A11)-mediated entry cystine into cells....
Rationale: Photothermal therapy employs the photoabsorbers to generate heat under near-infrared (NIR) irradiation for thermal tumor ablation. However, NIR might damage adjacent tissue due leakage of and residual materials after treatment hinder local healing process. A bifunctional hydrogel that holds both photothermal property potent pro-healing ability provides a viable option resolve this issue. Methods: In study, we developed bioinspired green (BVSF) with integration bioproduct...
Psoriasis is a common chronic immune-mediated skin disease characterized by hyperproliferation and aberrant differentiation of keratinocytes massive infiltration inflammatory immune cells. Recent studies showed that Signal Transducer Activator Transcription 3 (STAT3), which plays an important role in cell survival, proliferation, differentiation, angiogenesis, responses, constitutively activated epidermal human psoriatic lesions. In addition, STAT3 promotes the expansion T cells facilitates...
Psoriasis is a chronic inflammatory skin disease characterized by erythema, scaling, and thickening. Topical drug application recommended as the first-line treatment. Many formulation strategies have been developed explored for enhanced topical psoriasis However, these preparations usually low viscosity limited retention on surface, resulting in delivery efficiency poor patient satisfaction. In this study, we first water-responsive gel (WRG), which has distinct water-triggered liquid-to-gel...
Osteoarthritis (OA) is a chronic degenerative joint disease that affects worldwide. Oxidative stress plays critical role in the inflammation and OA progression. Scavenging overproduced reactive oxygen species (ROS) could be rational strategy for treatment. Bilirubin (BR) potent endogenous antioxidant can scavenge various ROS also exhibit anti-inflammatory effects. However, whether BR exert protection on chondrocytes treatment has not yet been elucidated. Here, were exposed to hydrogen...
Disulfiram (DSF) is a second-line drug for the clinical treatment of alcoholism and has long been proven to be safe use in practice. In recent years, researchers have discovered cancer-killing activity DSF, which highly dependent on presence metal ions, particularly copper ions. Additionally, free DSF unstable easily degraded within few minutes blood circulation. Therefore, an ideal formulation should facilitate co-delivery ions safeguard throughout its biological journey before reaching...
To improve tumor targetability and drug efficacy decrease resistance of dasatinib (DSB), the multifunctional micellar nanoparticles that combined matrix metalloproteinase 2 (MMP2)-sensitive (site) targeting with folate receptor-mediated (cell) were developed. Two major functional polymers, polyethylene glycol (5000 Da)-MMP2-sensitive peptide-phosphoethanolamine (PEG5k-pp-PE) folic acid-polyethylene (2000 Da)-phosphoethanolamine (FA-PEG2k-PE), synthesized to construct dual-targeted (MMP/FR...
Background/Aims: Diabetic cardiomyopathy is associated with increased apoptosis and suppressed autophagy in cardiac cells. The polyphenol resveratrol has shown beneficial effects various cardiovascular diseases. This study investigated if protected cells by modulating the context of diabetes. Methods: H9c2 myoblast were exposed to high glucose combined palmitate. Autophagy was evaluated estimating LC3-II/I ratio, P62 protein levels, LC3 fluorescent puncta. Apoptosis assessed using terminal...
Overcoming blood-brain barrier (BBB) and targeting tumor cells are two key steps for glioma chemotherapy. By taking advantage of the specific expression Na+-coupled carnitine transporter 2 (OCTN2) on both brain capillary endothelial cells, l-carnitine conjugated poly(lactic-co-glycolic acid) nanoparticles (LC-PLGA NPs) were prepared to enable enhanced BBB permeation glioma-cell targeting. Conjugation significantly uptake PLGA in cell line hCMEC/D3 T98G. The was dependent Na+ inhibited by...
l-Carnitine, obligatory for oxidation of fatty acids, is transported into cells by the Na+-coupled transporter OCTN2 and Na+/Cl–-coupled ATB0,+. Here we investigated potential L-carnitine-conjugated poly(lactic-co-glycolic acid) (PLGA) nanoparticles (LC-PLGA NPs) to deliver chemotherapeutic drugs cancer targeting both The cellular uptake LC-PLGA NPs in breast cell line MCF7 colon Caco-2 was increased compared unmodified nanoparticles, but decreased absence co-transporting ions (Na+ and/or...